Showing 126–150 of 200 documents
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Andrea Valenzuela
Tuberculosis (TB) remains the leading cause of death from infectious diseases, with treatment complicated by the growing prevalence of drug-resistant Mycobacterium tuberculosis (MTB) strains. Current regimens are largely standardized, overlooking substantial metabolic and genetic…
Abdul Kuddus
…d mathematical modelling to investigate the transmission of tuberculosis in Bangladesh, and identify optimal intervention strategies. He found that without rapid improvements in treatment quality the incidence of drug-resistant tuberculosis will continue to rise; whilst reasonabl…
Muhammed Rabiu Sahal
…hôtes entre M. africanum et d'autres membres du complexe M. tuberculosis. M. africanum a une gamme d'hôtes plus restreinte et est moins virulente et historique que M. tuberculosis, peut-être en raison d'une régulation différentielle des gènes impliqués dans la pathogenèse. Contra…
Ibrahim Bakshak Kefas, Isaac Isiko, Lenz Nwachinemere Okoro, Haroun Isa, Jackson Micheal Asingwire, et al.
…lateau State. Methods The data were obtained from the State Tuberculosis and Leprosy Control Programme Unit, and the population information was obtained from the National Population Commission. The spatial analysis techniques and time series considered the 17 local government are…
Margaret W. M. Akinbileje
…s an exploration of a research study conducted on Pulmonary Tuberculosis (PTB) infection that has claimed many lives. The incidence of TB in Nigeria in 2016 was estimated to be 219 cases per 100,000 population, which accounts for about 4% of the TB incidence globally. Nigeria hol…
Winnie Nakiboneka
Background: Tuberculosis (TB) remains one of the world's leading causes of adult morbidity and mortality resulting in an estimated 8.8 million incident cases and 1.4 million deaths Up to 92% of the TB cases occur in low and middle-income countries with the sub-Saharan Africa regi…
Simon A. Larsson
Tuberculosis is one of the deadliest infectious diseases in the world. It is exacerbated by the rise of multi-drug resistant strains. Host-directed therapies are an innovative approach by targeting host pathways to enhance immunity and suppress bacterial replication. The work des…
Julius Ebua Chia
…al for host-protective immune responses in diseases such as tuberculosis. Here, we used two Th1 models of intracellular pathogens Listeria monocytogenes (Lm) and Mycobacterium tuberculosis (Mtb), to understand the role of IL-4Rα signalling on Foxp3+ T regulatory cells. Infection …
I.V. Yeremenchuk
Coronavirus and tuberculosis, although caused by various pathogens, have many common features. In the pathogenesis of COVID-19 and tuberculosis the same features, a hyper-inflammatory reaction of the body, characterized by a pathological level of cytokines, is common. Specific im…
Raja Muhammad Naseer Khan
Tuberculosis (TB) is one of the oldest known human diseases, caused by <em>Mycobacterium tuberculosis</em>. The techniques currently employed for diagnosis are generally insensitive and non-specific. Positron emission tomography (PET) combined with computed tomography (CT) is use…
Evelin Dombay
Tuberculosis remains a major public healthcare issue. One main challenge in effectively managing the disease and novel drug development is the lack of predictive biomarkers. Current methods of determining the numbers of viable bacteria are inaccurate. Moreover, ‘persister’ bacter…
Florian Alexander Bourdeaux
…rial Dodecins In this thesis, the dodecins of Mycobacterium tuberculosis (MtDod), Streptomyces coelicolor (ScDod) and Streptomyces davaonensis (SdDod) were studied. Kinetic measurements of the flavin binding of MtDod revealed that the dodecin binding pocket is filled in two disti…
Oladokun, Ajibola Samson
… two billion people globally are believed to harbour latent tuberculosis infection (LTBI), which is a precursor to active tuberculosis (TB). Immunocompromising conditions, such as human immunodeficiency virus (HIV) infection, diabetes, chronic renal failure, and chemotherapy, are…
Suthidee Petsong
Tuberculosis (TB) is the global health concern because of the rising incidence and mortality. TB is caused by Mycobacterium tuberculosis complex (MTBC) and transmitted via inhalation of infectious droplet nuclei circulating in the air. The World Health Organization (WHO) recommen…
Wai Lai Chang
Tuberculosis (TB) remains the world’s second leading cause of death from a single infectious agent in 2022 after COVID-19[1]. The global number of people newly diagnosed with TB was over 10 million in 2022 [1]. There were an estimated 450 000 incident cases of MDR/RR-TB in 2021, …
Salam El Achkar
Tuberculosis (TB) is the first killer infectious disease, with 10 million new cases estimated worldwide in 2017. TB drug resistance and its diagnosis are particularly problematic. Only 25% of the 450,000 incident multidrug resistant (MDR) TB patients estimated over the same year …
V. Krishna, P Swetha, Rangu Srikanth Chandra
…is increasingly recognized as a significant risk factor for tuberculosis (TB), particularly in developing countries where both conditions are highly prevalent. The coexistence of these diseases complicates clinical outcomes and challenges TB control efforts. This study aimed to d…
Sarah A. MacLean
The current, most widely used method to screen for latent tuberculosis infection is the Mantoux tuberculin skin test, where tuberculin is injected into a patient's arm and may result in a cutaneous induration forming at the site of injection. A diameter measurement of the resulta…
Suthirote Meesawat, Suchinda Malaivijitnond, Saradee Warit
…mans and wildlife, is increasing during the global warming. Tuberculosis (TB) is an air-borne infectious disease that can be transmitted from humans to non-human primates (NHPs), however, no report of TB prevalence in free ranging NHPs that highly interacted with humans in Thaila…
Amparo Martinez Perez
…a bacterial infection, we will use as a model Mycobacterium tuberculosis (Mtb), responsible for Tuberculosis (TB). TB is a serious global health problem and the only licensed vaccine against TB is "Mycobacterium bovis Bacille Calmette-Guérin" (BCG). But BCG has a poor efficacy. T…
Putera, Iwan
…ight-threatening intraocular inflammation, can be caused by tuberculosis (TB). This thesis advances our understanding of ocular TB (OTB) by integrating immunological insights, clinical observations, and innovative diagnostic strategies. It combines findings from laboratory studie…
Kumari Seema, Abhay Kumar, Manju Boipai, Ashok Sharma, Manoj Kumar
… area is mirrored by the functional state and efficiency of tuberculosis control programs running in the country. Material and Method: A total of 549 cases were recruited during the period from 2017 to 2019 and the data were analysed retrospectively. Both pulmonary and extra-pulm…
Le, Van Hong
Multidrug-resistant tuberculosis (MDR-TB) has been an emerging public health problem. MDR-TB is a fatal disease whilst treatment of MDR-TB is prolonged but less effective and toxic. Inter-individual variations in clinical presentation and treatment response have been reported in …
Hoogkamer, Emily
Tuberculosis (TB) is a major cause of death worldwide. We have a limited understanding of how the human immune system responds to Mycobacterium tuberculosis (M.tb), the main infectious agent that causes TB. In this project, non-human primates (NHPs) were exposed by aerosol to 1x1…
Nataliya Vrubleuskaya
Tuberculosis (TB) is a bacterial infectious disease. The majority of TB patients in the Netherlands are successfully treated but in some patientsextension of treatment duration is necessary due to complications. Only in a small number of patients this treatment fails. This thesis…