Showing 1–25 of 49 documents
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Xiaonan Geng, Fan Zhang, Ruichao Liu, Fuzhen Zhang, Ziwen Li, et al.
… and compare the effectiveness of different DR-TB treatment regimens and to assess their safety profiles based on the frequency of adverse events and drug-specific reactions. **METHODS:** We systematically searched PubMed, Web of Science, and Embase for relevant studies publishe…
Ginenus Fekadu, Tadesse Tolossa, Firomsa Bekele, Xiaohan Chen, Yan He, et al.
…line (Bdq), has led to the development of shorter treatment regimens. This systematic review and meta-analysis aimed to examine the impact of these regimens, synthesising data from recent clinical trials and observational studies. **METHODS:** We searched multiple databases, inc…
Mark Kosenko, Lilit Davtian, Ekaterina Iakovleva, Mukhammad Ashurov, Dmitrii Podgalo, et al.
…onths of isoniazid (9H) versus shorter rifamycin-containing regimens for treating latent tuberculosis infection (TBI) in children. **METHODS:** We systematically searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials to June 2025 for randomized, controlled …
Zhen Feng, Hailan Wu, Qian Li, Xiaoqiang Zhang, Qingfeng He, et al.
**OBJECTIVES:** High-dose rifamycin (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR regimens. **DESIGN:** Using a systematic review and Bayesian network meta-analy…
Yihui Zhou, Hongxia Niu
… TB (RR-TB) posing critical challenges. Conventional longer regimens are characterized by suboptimal effectiveness, high toxicity, and poor tolerability. Consequently, there is an urgent demand for more effective, safer, shorter regimens with enhanced tolerability to replace trad…
Wamaka Kaminyoge, Reuben Simfukwe, Mwiza Singini, Norman Sitali, Felix P Chilunga
…B) face major treatment challenges. Although newer all-oral regimens have transformed adult TB care, their use in younger populations has largely been extrapolated from adult studies, despite important biologic and clinical differences. Systematic and up-to-date evidence on the e…
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin-Gun Cho, Jan-Willem C Alffenaar
…dies that reported AE data for bedaquiline-pretomanid-based regimens. In total, 14 studies from various countries were included in the analysis, comprising seven clinical trials, six implementation studies and one pharmacovigilance study. AE detection methods differed between cli…
Yipeng Sun, Idris Sula, Muhammad Candragupta Jihwaprani, Nazmus Saquib
…patients with DR-TB following treatment with BDQ-containing regimens. Five electronic databases (CENTRAL, Clinicaltrials.gov., PubMed, ScienceDirect, and SinoMed) were searched for this meta-analysis of randomized controlled trials (RCTs; PROSPERO: CRD42024571134). RCTs with a BD…
Beatriz Bernava Sarinho, Inajara Rotta, Tácio de Mendonça Lima, Brígida Dias Fernandes, Patricia Melo Aguiar, et al.
…uating the efficacy, effectiveness, and safety of different regimens. Thus, this protocol outlines the approach for systematically reviewing and synthesizing the existing literature regarding the efficacy, effectiveness, and safety of different regimens for histoplasmosis and tub…
Yang Li, Ammar Saad, Zhen Feng, Shijia Ge, Lingyun Song, et al.
…remain poorly defined, and there is no consensus on optimal regimens, duration, or outcomes. **METHODS AND ANALYSIS:** We will conduct a systematic review of observational and interventional studies reporting anti-TB treatment in patients with asymptomatic TB. Databases includin…
Ashutosh N Aggarwal, Ritesh Agarwal, Sahajal Dhooria, Perumal K Bhavani, Kuruswamy T Prasad, et al.
Standard rifampicin doses used to treat pulmonary tuberculosis lie at the lower end of drug exposure-response curve. We evaluated if higher daily rifampicin doses result in greater efficacy or harm. We searched literature databases for randomized controlled trials comparing effic…
Morrish Obol Okello, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB treatment, is linked to QT interval prolongation, a risk fac…
Mita Restinia, Jheng-Yan Wu, Fajri Gafar, Wen-Hsuan Hou, Chung-Yi Li
…s evaluated the safety and efficacy of linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis. Seven databases (January 2001-February 2026) were searched for randomized controlled trials comparing linezolid-containing regimens with standard of care (SOC). P…
Agathe Béranger, Belén P Solans, Ryo Miyakawa, Helen McIlleron, Joel Tarning, et al.
… attain our pharmacological target for all children, dosing regimens could be adjusted on NAT2 genotype and nutritional status.
Mohamad Faisal Said Al Omar, Izz Eddin Majed Alchikhsuliman, Sondos Mahmoud Awad, Numa Rajab, Yousef Mohammed Alawi, et al.
… and AST (10.4%). Among the individual drugs, Pa-containing regimens had the highest incidence of elevated liver enzymes (ALT [18.9%], AST [20.3%], and GGT [12.8%]). DLM-containing regimens had the lowest incidence (ALT [0.2%], AST [0.7%], and GGT [1%]). For BDQ-containing regime…
Emma C Carter, Victoria Simpson, Tilly Fox, Andrea M Collins, Stephen B Gordon, et al.
**OBJECTIVES:** This systematic review aims to synthesize the best available evidence on antimycobacterial management of Bacille Calmette-Guérin (BCG) infection in hosts without significant immunocompromise. **METHODS:** We performed a systematic review searching Medline, S…
Alberto Matteelli, Sofia Lovatti, Benedetta Rossi, Luca Rossi
…th of bedaquiline regimen compared with WHO-recommended TPT regimens. Preventing MDR/rifampicin-resistant TB remains a significant challenge for the global elimination of TB. Although the recent WHO recommendation for 6 months of daily Lf is a promising step, expanding the TPT op…
Liai Peng, Yiqing Zhou, Min Wang, Zhipeng Zu, Qian Wu, et al.
… 74.3% - 86.0%), recipients of isoniazid-rifapentine regimens (76.5%, 95% CI: 69.5%-82.9%), and twice-weekly dosing schedules (76.5%, 95% CI: 69.5%-82.9%). This study revealed the suboptimal uptake of TPT among children and adolescents with LTBI in China. These findings hi…
Lies Dina Liastuti, Kelvin Kohar, Haifa Mayang Lestari, Armalya Pritazahra
…lity. Management requires complex, individualized treatment regimens. Emerging evidence suggests that contemporary antituberculosis agents for drug-resistant disease carry significant cardiotoxicity risk. This study aims to evaluate the cardiovascular toxicity of current therapeu…
Maria-Angelica B Lerma, Ayla Niel L Castillo, Gelza Mae A Zabat
…nimal, but the studies significantly differed in the dosing regimens of the intervention, populations included, and attrition rates. The RoB was also low, but there were concerns due to high attrition rates, lack of blinding, and the addition of unplanned post-hoc analysis. The b…
Md Zamiur Rahaman, Tahmina Alam, Syeda Shamsun Nahar, Ridwana Nahrin, Israt Jahan Bushra, et al.
… success rates for drug-sensitive TB reached up to 97%. New regimens incorporating bedaquiline and delamanid for multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB) showed cure rates as high as 94.6%. **CONCLUSION:** Overall, shorter treatment regimens were a…
Md Mahmudul Islam, Md Zahid Hasan, Md Touki Tahamid Tusar, Md Yeamin Hossain, Md Motaher Hossain, et al.
…factor binding. Clinical studies showed that DLM-containing regimens improve culture conversion and treatment success, especially when combined with oral agents such as bedaquiline and linezolid. Safety data indicate that DLM is generally well tolerated, with QT prolongation bein…
Svetlana Degtyareva, Yohhei Hamada, Rebecca F Baggaley, Nasser Hassan, Santino Capocci, et al.
…ing, immunological testing, treatment start and completion. Regimens lasting <6 months had higher completion rates (88.4%) than those lasting 6-9 months (74.4%) or >9 months (61.6%). **CONCLUSIONS:** Our analysis highlights substantial loss to follow-up at m…
Omri A Arbiv, Thomas Holmes, Marie JeongMin Kim, Marie Yan, Kamila Romanowski, et al.
…hat only 2 included studies were blinded. **CONCLUSIONS:** Regimens that used TDR were associated with an increase in SevAEs, raising concerns regarding safety of TDR regimens.
Alice Bai, Hari Dandapani, Amrita Dosanjh
…, with a median treatment duration of 30 weeks. Common regimens included combined ethambutol with rifampin (n=9) or clarithromycin (n=6), and clarithromycin with amikacin (n=6). Most patients started on therapy for tuberculosis before switching treatment courses after NTM di…