Showing 51–74 of 74 documents
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I Made Bayu Anggriawan, Ike Dhiah Rochmawati
…s has contributed to the rising prevalence of antimicrobial resistance. However, limited studies have systematically analyzed the prevalence of fluoroquinolone resistance (FQR) and its associated risk factors. **METHODS:** A systematic review and meta-analysis were conducted, sc…
Ratnesh Sinha, Agus Fitriangga, Anushka Priya Sharan, Sameer Uz Zaman, I Wayan Gede Artawan Eka Putra, et al.
…nagement, leading to treatment failure and the emergence of drug-resistant tuberculosis (DRTB). **METHODS:** This systematic review and meta-analysis (PROSPERO ID: CRD42024557140) sought to evaluate the prevalence of loss to follow-up (LTFU) and the associated factors among Drug…
Ravindra Kumar Garg, Rajiv Garg, Akshaya Anand Agrawal, Sanjay Singhal, Raza Abbas Mahdi
… 38.4%. Anti-TB therapy was administered to 79.5%; 8.2% had drug-resistant TB. Neonatal TB manifestations included congenital TB (39.7%), miliary TB (34.2%), and CNS TB (15.1%). Of 55 live births, 28 infants survived, 12 died neonatally, and outcomes were missing for 15; there we…
Sanjay Singhal, Ranganath Ganga, Pulkit Gupta, Aneeket Rastogi, Shilpi Arya, et al.
…* With the increasing use of Linezolid for the treatment of drug-resistant tuberculosis, concerns have emerged about serious adverse effects, including optic neuritis. **OBJECTIVES:** To systematically review available evidence on the incidence reported in the cohort, onset, lin…
Rogers Kamulegeya, Rose Nabatanzi, Derrick Semugenze, Faridah Mugala, Mercy Takuwa, et al.
… and treatment failure contributes to ongoing transmission, drug resistance, and poor clinical outcomes. Artificial intelligence and machine learning approaches have attracted growing interest for predicting tuberculosis treatment outcomes, but the literature is heterogeneous and…
Johnessa Cung, Patihul Husni, Kyung Taek Oh
… treatment regimens that lead to poor patient adherence and drug resistance, as well as diagnostic tools that lack sensitivity and specificity. This systematic review evaluates recent advancement in actively targeted nanoparticle (NP) systems designed to improve TB diagnosis, tre…
Ana Luíza Brasileiro Nato Marques Assumpção, Flávia Correia Silva, Licia Kellen de Almeida Andrade, Quézia Rosa Ferreira, Gilberto da Cruz Leal, et al.
…dies focused on pulmonary tuberculosis, with one addressing drug-resistant tuberculosis. The results revealed that women's experiences with tuberculosis are shaped by the following four thematic categories: (1) stigma and social vulnerability of women with tuberculosis; (2) gende…
Hanxin Wu, Liangyu Zhu, Rui-An Bao, Suyi Luo, Li Peng, et al.
…al attainment 0.39 % (95 % CI: 0.31 to 0.47), and drug-resistant tuberculosis 7.0 % (95 % CI: 4.6 to 9.4) as significantly associated with higher co-infection prevalence. Regional variation was also significant, with Africa showing the highest burden. No assoc…
Emilyn Costa Conceição, Felicia Wells, Abhinav Sharma, Mishka Haffejee, Brendon Mann, et al.
…) holds promise for accurate and comprehensive diagnosis of drug resistance inand identification of transmission events. 'Early positive cultures' (EPC) are increasingly used when WGS is implemented to guide clinical care to reduce the turnaround time. We performed a systematic l…
Maria-Angelica B Lerma, Ayla Niel L Castillo, Gelza Mae A Zabat
… status (sufficiency/insufficiency/deficiency), presence of drug resistance, and genetic polymorphisms; these may be explored in future studies sufficiently powered to examine such a relationship.
Leeberk Raja Inbaraj, Vignes Anand Srinivasalu, Mukesh Kumar Sathya Narayanan, Adhin Bhaskar, Jefferson Daniel, et al.
…viduals with active tuberculosis in community settings, and drug-resistance surveys. We extracted data using a standardised form and assessed risk of bias and applicability using the revised Quality Assessment of Diagnostic Accuracy Studies tool. We contacted study authors for fu…
Doris Y Sakala, Jacques M Tamuzi, Constance S Shumba, Peter S Nyasulu
…single infectious pathogen. The rise in prevalence of multi-drug-resistant tuberculosis (MDR-TB) puts an increased burden on the health system in terms of cost and longer treatment duration. People living in correctional facilities are more likely to develop TB and have poor TB t…
Abayeneh Girma, Fentaye Kassawmar, Yeshiwas Kassa, Yeshwas Asrat
…ll clinical presentations of the disease, including active, drug-resistant, HIV-related, latent, and extrapulmonary TB. These advancements not only enhance the diagnostic landscape but also facilitate timely and effective treatment strategies, ultimately aiming to reduce the burd…
Olivia Alise D'Silva, Samantha Lancione, Oviya Ananthakrishnan, Angelina Addae, Suvesh Shrestha, et al.
…94 USD. Costs were consistently higher amongst persons with drug resistant TB (DR-TB) and those identified through passive case finding (PCF). Hospitalization and loss of income were the largest drivers of cost. Despite many countries offering free TB treatment, patients still in…
Saeid Sadeghi Ghazi Chaki, Saeed Babaie Pirsoltan, Masoumeh Beig, Tahereh Navidifar, Elnaz Parvizi, et al.
**BACKGROUND:** Macrolide resistance in Mycobacterium species is an emerging global problem, complicating treating non-tuberculous mycobacteria (NTM) and Mycobacterium tuberculosis. Understanding global resistance patterns is essential to improve treatment strategies and reduce m…
Xiting Dai, Hanxin Wu, Liangyu Zhu, Zhiqiang Chen, Weijie Ma, et al.
…terial agent pivotal in the management of. The emergence of resistance to EMB, primarily driven by mutations in thegene, constitutes a formidable challenge to global tuberculosis (TB) eradication efforts. This meta-analysis followed PRISMA (Preferred Reporting Items for Systemati…
Egide Ndayambaje, Olivier Sibomana, Marvellous Asika, Grace Marie Uwizeyimana, Gabriel Oke, et al.
…gh-risk environments for the acquisition and spread of multidrug-resistant organisms (MDROs). This scoping review aims to map the existing evidence on antimicrobial resistance (AMR) in prisons and refugee camps, focusing on burden, risk factors, surveillance, resistance patterns,…
Zi-Ke Chen, Zhao Wu, Ting Ye, Chao-Yang Lin, Xu-Guang Guo
… in identifying LNTB in different age groups and rifampicin resistance in LNTB patients. **METHODS:** A systematic search of Embase, Cochrane Library, PubMed, Web of Science, and Scopus up to October 26, 2023, was conducted. Studies comparing Xpert MTB/RIF with culture and CRS w…
Nichola R Naylor, Mateusz Hasso-Agopsowicz, Chaelin Kim, Yixuan Ma, Isabel Frost, et al.
**INTRODUCTION:** Antibiotic resistance (ABR) may increase hospital costs, utility loss and mortality risk per patient. Understanding these losses at national, regional and global scales is necessary for efficiently tackling ABR. Our aim is to estimate the global economic burden …
Yihui Zhou, Hongxia Niu
…is (TB) remains a global public health emergency, with multidrug-resistant TB (MDR-TB) and rifampicin-resistant TB (RR-TB) posing critical challenges. Conventional longer regimens are characterized by suboptimal effectiveness, high toxicity, and poor tolerability. Consequently, t…
Youssra Metarfi, Wissal Chellal, Zineb Ben Khadda, Hasnae Hoummani, Bouchra Amara, et al.
…ES:** The treatment of tuberculosis (TB) depends on anti-TB drugs to eradicate the infection and prevent its transmission. Variability in drug metabolism, interactions, and adherence can affect treatment efficacy. Therapeutic drug monitoring (TDM) is essential for optimizing trea…
Jaishriram Rathored, Tanushree Budhbaware, Sandesh Shende, Vishwanath Upadhyay
…tibility to tuberculosis (TB), and the introduction of multidrug-resistant tuberculosis (MDR-TB) has made disease control even more challenging. The time-consuming nature of conventional drug susceptibility testing (DST) emphasizes the critical need for quick biomarkers to foreca…
Nakwon Kwak, Joong-Yub Kim, Areum Han, Catherine Berry, Maria Beumont, et al.
… The optimal dosing strategy of linezolid for treating multidrug-resistant and rifampicin-resistant tuberculosis remains unclear. We conducted an individual patient data meta-analysis to determine the optimal linezolid dosing strategy. **METHODS:** We searched for randomised con…
Jessica Liu, Benjamin Chin-Yee, Jenny Ho, Alejandro Lazo-Langner, Ian H Chin-Yee, et al.
…ed a systematic review to inform the clinical management of drug-induced erythrocytosis. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we performed a systematic literature search in MEDLINE, EMBASE, CENTRAL (all via Ovid), and Google Sch…