Showing 26–50 of 75 documents
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Sonia Menon, Anthony D Harries, Riitta A Dlodlo, Gisèle Badoum, Mohammed F Dogo, et al.
…on (TBI) serving as the primary source of TB disease. While HIV infection has long been recognised as a major risk factor for TB progression, the rise of Non-Communicable Diseases (NCDs), which may exert immunosuppressive effects, further compounded by their treatment, contribute…
Paul W Bird, Daniel Pan, Kentaro Trerattanavong, Christopher A Martin, Christopher Holmes, et al.
…high incidence of communicable diseases [tuberculosis (TB), HIV, and hepatitis B (HBV) and C (HCV)]; has increased the need for cost-effective early disease diagnosis programmes to improve outcomes. We aimed to synthesize and evaluate current literature on community-based screeni…
Svetlana Degtyareva, Yohhei Hamada, Rebecca F Baggaley, Nasser Hassan, Santino Capocci, et al.
…rculosis (TB) incidence and mortality in people living with HIV can be reduced by TB preventive treatment (TPT). However, low levels of screening and uptake, poor adherence, and loss to follow-up considerably reduce its effectiveness. We therefore aimed to assess the losses withi…
Clément Conil, Jonathan Bohlen, Elouise E Kroon, Marc A Jean-Juste, Jérémy Manry, et al.
… this phenotype by hypothesizing that resisters living with HIV, a major risk factor for TB, would be enriched in genotypes conferring resistance. **METHODS:** We enrolled two cohorts of people living with HIV (PWH), consisting of 55 resisters and 100 controls-either positive fo…
Behailu Taye, Haile Tesfaye, Gemechu Churiso
…oC) assay for tuberculosis (TB), especially for people with HIV (PLHIV). The Fujifilm SILVAMP TB LAM (FujiLAM), a urine lipoarabinomannan assay, has shown promise for diagnosing TB in PLHIV. But diagnostic performances were inconsistent across studies. This systematic review and …
Morrish Obol Okello, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
…lth challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB treatment, is linked to QT interval prolongation, a risk factor for life-threatening arrhythmias. This systematic review and-analysis…
AbdulAzeez Lawal, Abimbola Hussein, Simon Tiberi, Heinke Kunst
…comes and reducing TB-related mortality. People living with HIV (PLWH) are at a higher risk of developing and dying from TB. This systematic review aims to identify barriers and enablers affecting TB treatment adherence among people with HIV/TB coinfection. **METHODS:** A system…
Dao Weiangkham, Adinat Umnuaypornlert, Surasak Saokaew, Neeranuch Wongcharoen, Samrerng Prommongkol, et al.
…= 0.019), comorbidity (OR 1.44, 95 % CI 1.17-1.78,= 0.001), HIV patient (OR 1.40, 95 % CI 1.16-1.69,= 0.001), patients with ADR (OR 2.19, 95 % CI 1.47-3.26,< 0.001), MDR TB (OR 3.16, 95 % CI 2.31-4.32,< 0.001), and miliary TB (OR 1.37, 95 % CI 1.10-1.70,= 0.004) with minimal hete…
Chieh-Yin Wu, Chu-Chang Ku, Christopher Finn McQuaid, Knut Lönnroth, J Peter Cegielski, et al.
…ransmission models for 12 high TB burden countries with low HIV prevalence. We explicitly accounted for the effects of BMI on TB disease progression and treatment outcomes using a meta-analysis of longitudinal cohort studies, incorporating the effect of BMI mediated through diabe…
Benjamin Freitag, Ayten Sultanli, Maurizio Grilli, Stefan Fabian Weber, Mary Gaeddert, et al.
…of TB diagnosed clinically was higher in people living with HIV and extrapulmonary TB. Clinical diagnosis did not differ by diagnostic modality available or by study year. The pooled risk ratio for mortality (n = 20,523, 10 studies) was 1·5 (95% CI: 1·0-2·2,= 78&#x…
Morrish Okello-Obol, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
…f drug-resistant TB (DR-TB) and its strong association with HIV. Bedaquiline (BDQ), approved by the WHO in 2013, offers a promising treatment for DR-TB, including multidrug-resistant TB (MDR-TB) and extensively DR-TB (XDR-TB). However, BDQ has been associated with QT interval pro…
Maria Magdalene Namaganda, Joyce Nakatumba Nabende, David Patrick Kateete, Charles Batte, Gerald Mboowa
…erapy (ART) in East Africa, viral non-suppression, advanced HIV disease (AHD), and multimorbidity persist, reflecting gaps in service response rather than regimen potency alone. In Uganda's The AIDS Support Organization (TASO) routine-care cohort (2014-2024; = 54,34…
Tariku Derese, Yibekal Manaye, Bereket Damtew, Muluken Yigezu, Tewodros Getnet, et al.
… studies, elevating serum levels and reducing viral load in HIV patients. However, it did not affect weight gain or mortality in TB and HIV patients. While symptom and biomarker improvements were noted, further research is needed to explore subgroup effects and optimize strategie…
Dereje Dana Zeruma, Mesfin Kote, Eshetu Zerihun, Getahun Gedabo, Biruk Wogayehu
…ly, including 161,000 TB-Human Immunodeficiency Virus (HIV) infections. It affects 10.6 million people, mainly in Asia and Africa, 75% of whom are in the economically active age group of 15–54 years. Treatment interruptions hinder efforts to eliminate TB by 2030.…
Eliza Miranda Ramos, Carolina Braga Sisti, Sérgio Beltrão de Andrade Lima, Emerson Luiz Lima Araújo, Lúcia Dias da Silva Guerra, et al.
… a 2.3 times higher risk of treatment abandonment, while TB-HIV coinfection increased mortality by up to threefold. **CONCLUSION:** The vulnerability of the HP to TB is strongly linked to social and programmatic factors. Intervention strategies should prioritize social protectio…
Rogers Kamulegeya, Rose Nabatanzi, Derrick Semugenze, Faridah Mugala, Mercy Takuwa, et al.
…geneity (I= 97.9%). In subgroup analyses, studies including HIV-positive participants showed lower discrimination (pooled area under the curve 0.748) compared to those excluding them (0.924). Only eight studies (23.5%) performed external validation, and only one study (2.9%) was …
Youssra Metarfi, Wissal Chellal, Zineb Ben Khadda, Hasnae Hoummani, Bouchra Amara, et al.
…n, and patients with MDR- and XDR-TB, as well as those with HIV co-infection. The studies examine a range of anti-TB drugs, from first-line treatments like isoniazid and rifampicin to second-line options such as bedaquiline and linezolid. Various sampling methods were employed, i…
Yihenew Sewale Bizu, Kassahun Dires Ayenew
…igma reduction strategies, and provide tailored care for TB-HIV co-infected patients, especially in rural areas with limited resources is essential.
Oumar Abakar Mahamed, Noussissy Sandokane Hounnoukon, Soraya Laraqui Houssaini, Imane El Faziki, Meryeme Kirat, et al.
…95% CI 94.4% to 96.5%. Previous exposition to TB treatment, HIV infection, smoking and the presence of comorbidities were the most reported associated factors. **CONCLUSION:** This review underscores the persistence of MDR-TB in the MENA region, suggesting insufficiency in TB co…
Ginenus Fekadu, Tadesse Tolossa, Firomsa Bekele, Xiaohan Chen, Yan He, et al.
…s showed no significant differences in TSR by DR-TB type or HIV status. The incidence rate of SAE was 19% (13-24), with prolonged corrected QT interval (QTc) in 5% (2-8) of cases. Compared with the control regimens, all-oral Bdq-based shorter regimens significantly improved treat…
Abayeneh Girma, Fentaye Kassawmar, Yeshiwas Kassa, Yeshwas Asrat
…entations of the disease, including active, drug-resistant, HIV-related, latent, and extrapulmonary TB. These advancements not only enhance the diagnostic landscape but also facilitate timely and effective treatment strategies, ultimately aiming to reduce the burden of TB worldwi…
Ying Gao, Wenjuan Ji, Qiuyan Chen
…ws promise as a biomarker for TB screening, particularly in HIV-positive cases, with demonstrated sensitivity and specificity in meta-analyses.MethodsWe performed a meta-analysis to assess the accuracy of CRP for screening HIV-associated PTB in outpatients, combining the sensitiv…
Alhassane Diallo, Boubacar Djelo Diallo, Oumou Hawa Diallo, Miguel Carlos-Bolumbu, Mohamed Camara, et al.
…unctive corticosteroids on mortality in persons living with HIV (PLHIV) being treated for tuberculosis (TB). **DESIGN:** Systematic review and meta-analysis. **DATA SOURCES:** PubMed, CENTRAL and EMBASE through 31 December 2023 STUDY SELECTION: Randomised placebo-controlled tri…
Deresse Daka, Belay Tessema, Awelani Mutshembele, Amir Alelign, Wubet Birhan, et al.
…R-TB) patients, and 4.6% were Human Immunodeficiency virus (HIV) positive. The NTM prevalence was 3.8%, showing high heterogeneity and regional species variability. The meta-analysis highlighted differences in NTM prevalence across age groups and diagnostic tools, emphasizing the…
Unjali P Gujral, Peijue Huangfu, Amanuel A Kisho, Elizabeth S Limb, Dzigbordi Kamasa-Quashie, et al.
… **FUNDING:** The World Health Organization Department for HIV, Tuberculosis, Hepatitis and Sexually Transmitted Infections and the Department of Noncommunicable Diseases and Mental Health, and the Preventive Treatment of Latent Tuberculosis Infection in People with Diabetes Mel…