Showing 26–49 of 49 documents
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Bhavani Perumal Kannabiran, Jayanthi Arthanari, Adhin Bhaskar, Mukesh Kumar Sathya Narayanan, Leeberk Raja Inbaraj
Background & objectives Evidence suggests that higher doses of rifampicin aid in faster culture conversion, but its effects on unfavourable outcomes are unclear. We aimed to synthesise evidence on the efficacy and safety of high-dose rifampicin (>15 mg/kg) containing anti-tubercu…
Kabelo Gabriel Kaapu, Vukosi Treasure Makondo, Emilyn Costa Conceição, Ivy Rukasha
…ng patients with MDR- or XDR-TB treated with BDQ-containing regimens in South Africa.: PubMed, Web of Science, and Embase were searched for studies published between January 2016 and July 2024.: Study quality was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal…
Vishal Kumar, Sitanshu Barik, Shivji Prajapati, Lakshmana S Das, Vikash Raj
Total hip replacement (THR) in the tuberculous (TB) hip joint can be done in the same sitting or in a staged manner. The study aimed to analyse evidence within the current literature on single-stage THR in active TB hip in terms of duration and regimen of anti-tubercular treatmen…
Warinmad Kedthongma, Sopon Usaprom, Wuttiphong Phakdeekul
…trol must integrate socioeconomic support alongside medical regimens to achieve meaningful outcomes.
Hanie Sakhi, Maryam Meskini, Mojgan Sheikhpour
… drug-resistant (XDR) strains. Bedaquiline (BDQ)-containing regimens have become important for the treatment of MDR/XDR-TB, and resistance to BDQ is increasing. Understanding genetic mutations is crucial for early detection of BDQ-resistant strains and thus maintaining the effect…
Maria Magdalene Namaganda, Joyce Nakatumba Nabende, David Patrick Kateete, Charles Batte, Gerald Mboowa
Despite widespread rollout of dolutegravir-based (DTG) antiretroviral therapy (ART) in East Africa, viral non-suppression, advanced HIV disease (AHD), and multimorbidity persist, reflecting gaps in service response rather than regimen potency alone. In Uganda's The AIDS Support O…
Zipporah Dery, Celso Pagatpatan, Margel Bonifacio
**OBJECTIVE:** This qualitative systematic review will explore the barriers and facilitators of the use of digital adherence technologies for tuberculosis treatment. The review will focus on the human factors that support the use of these technologies in tuberculosis treatment. …
Michael Prodanuk, Sarah L Silverberg, Pierre-Philippe Piché-Renaud, Daniel S Farrar, Jessie Cunningham, et al.
…ne were at high risk of bias. **CONCLUSIONS:** Higher-dose regimens in children were associated with increased AEs, raising caution for further dose increases and necessitating additional study of treatment tolerability. These findings are limited by publication bias in observat…
Pranav Shivashankar, Praween Senanayake, Thomas Stephen Ledger, Nicholas Ngui
…DS:** Reports describing confirmed TTA, specified treatment regimens and clinical outcomes were systematically identified and synthesised from PubMed, Embase, Web of Science and Google Scholar from the period 1990 to 2025. Studies with suspected but unconfirmed cases were exclude…
Hui Ming, Biao Fu, Xiaogang Chen, Wenbing Hu, Hui Yu
…th a significantly increased risk of TB compared to non-ICI regimens. Importantly, patients with a history of prior TB were found to be at significantly higher risk. This highlights the critical need for enhanced TB screening and vigilant monitoring, especially in this vulnerable…
Amy Nel, Mary E Miller, Hanna-Andrea Rother
**BACKGROUND:** The impact of environmental health risk factors on the optimization of health in MDR-TB infected individuals, as well as on the prevention of transmission to household contacts, is not well documented. Establishing the recommendations of environmental health risk …
Pablo Troop, Brenna Keam, Caroline Mullen, Julius Nyerere Odhiambo
**INTRODUCTION:** Tuberculosis (TB) is a notable public health issue in sub-Saharan Africa (SSA), disproportionately affecting vulnerable populations such as nomads. Their migratory lifestyles limit consistent access to TB diagnostic and treatment services, leading to delays in d…
William J Burman, M Florencia Martins, David Flynn, James Johnston, Pranay Sinha, et al.
**BACKGROUND:** Treatment-related adverse events are one of the leading barriers to tuberculosis treatment completion but have not been the focus of late-phase clinical trials. We performed a scoping review to identify interventions to improve the safety and tolerability of rifam…
Emy Oktaviani, Kusnandar Anggadiredja, Lia Amalia
…DRs in drug-resistant tuberculosis patients with individual regimens, having access to the full text, and using the English or Indonesian language. Potential reporting bias was minimized by comprehensive database search and duplicate screening.Initially, we identified 650 potenti…
Xianni Wei, Ruina Cai, Xiaohong Wu, Yonglong Su, Siheng Lian, et al.
…stic criteria (ALT > 3ULN vs. >5ULN), anti-TB regimens (3-drug vs. 4-drug), HCV definition (antibody vs. RNA positivity), and study design (prospective vs. retrospective). **RESULTS:** Thirteen studies comprising a total of 3,174 patients met the inclusion criteria…
Christina Zouganeli, Dimitra K Toubanaki, Ourania Karaoulani, Georgia Vrioni, Evdokia Karagouni, et al.
…. Treatment success rates showed a modest rise for 24-month regimens, while outcomes declined for 12-month therapies.These findings underscore the pandemic's disruptive impact on TB control and highlight the need for renewed investment in diagnostic capacity, treatment access, an…
Andrea Llamas-Lopez, James A Seddon, Felicia C Chow, Caryn M Upton, Sanjay K Jain, et al.
**BACKGROUND:** Tuberculous meningitis (TBM) remains the deadliest form of tuberculosis. Inadequate penetration of rifampicin and ethambutol into the brain and cerebrospinal fluid (CSF) may contribute to mortality. Over the last decade, research has focused on "intensified" treat…
Omar Oliveira Meira, Luiz Gustavo Ribeiro Silva, Raquel Fonseca Sales, Renata Maria Colodette, Lucas Borges Gomes Ferreira Pinto, et al.
**INTRODUCTION:** Tuberculosis, although curable, presents challenges related to treatment adherence, which compromises treatment effectiveness. Individual, social and structural barriers interfere with patients' ability to properly follow the therapeutic regimen, thereby impacti…
Nakwon Kwak, Joong-Yub Kim, Areum Han, Catherine Berry, Maria Beumont, et al.
… prospective cohort studies on short-course all‑oral regimens containing linezolid for treating multidrug-resistant and rifampicin-resistant tuberculosis in PubMed, Embase and Scopus up to 31 August 2023. Patients were grouped according to linezolid dosing patterns. Time t…
Mohammed Alsaeed, Khalid Alanazi, Ali Alhamdan, Mohammed Faqihi, Alaa Alibrahim, et al.
…tions in conventional microbiological techniques. Treatment regimens based on macrolides and fluoroquinolones yielded superior therapeutic outcomes, exhibiting lower relapse rates and fewer adverse effects compared with conventional anti-TB therapy. Surgical interventions played …
Johnessa Cung, Patihul Husni, Kyung Taek Oh
…mortality worldwide, hampered by prolonged, toxic treatment regimens that lead to poor patient adherence and drug resistance, as well as diagnostic tools that lack sensitivity and specificity. This systematic review evaluates recent advancement in actively targeted nanoparticle (…
Ramesh Kumar, Abhishek Kumar, Sudhir Kumar
… a heavy disease burden. Although current anti-TB treatment regimens demonstrate high efficacy, the hepatotoxic potential of first-line anti-TB drugs (ATDs) - particularly isoniazid, rifampicin, and pyrazinamide-poses a considerable risk, as these agents are associated with a sig…
Jessica Liu, Benjamin Chin-Yee, Jenny Ho, Alejandro Lazo-Langner, Ian H Chin-Yee, et al.
Secondary erythrocytosis refers to an elevation in hemoglobin or hematocrit due to elevated serum erythropoietin levels. Medications including testosterone and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are increasingly recognized as causes of secondary erythrocytosis. We…
Gehang Ju, Xin Liu, Meng Gu, Lulu Chen, Xintong Wang, et al.
…fampicin. Extracted data included basic information, dosing regimens, sampling strategies, model parameters, and covariate details. Non-English studies, non-parametric models, and duplicates were excluded. The repository was built using R package mrgsolve, and a Shiny application…