Showing 26–50 of 74 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Md Mahmudul Islam, Md Zahid Hasan, Md Touki Tahamid Tusar, Md Yeamin Hossain, Md Motaher Hossain, et al.
…reatment progress is increasingly threatened by rising multidrug-resistant tuberculosis (MDR-TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug-susceptible and drug-resistant() strains. However, data on its resistance mechanisms, dru…
Helen Zhang, Naomi Medina-Jaudes, Alicia Forcada-Nadal, Ewan M Harrison, Francesc Coll
…utated MTBC loci across patients and estimated the rates of drug resistance (DR) acquisition during treatment. **RESULTS:** Using 5882 high-quality genomes from 1044 patients with TB, we identified 21 genes, 25 operons, and 27 promoter regions statistically enriched by mutations…
Majed Al-Mourgi, Anwar Shams, Majed Wasal Al-Morgi, Ziyad Al-Morgi
**BACKGROUND:** The incidence and prevalence of multi-drug-resistant and extensively drug-resistant pulmonary tuberculosis are increasing, posing profound health concerns; therefore, surgical intervention is gaining popularity again. However, the effectiveness of surgical treatme…
Erum Siddiqui, Mohammad Saad Khan, Maliha Khalid, Harshika Khaim Chandani, Umaimah Naeem, et al.
…olution in combating TB, particularly in the face of rising drug-resistant strains and suboptimal current vaccines. It has the potential to address the unmet need for more effective interventions against drug-resistant TB, a growing global health issue that continues to challenge…
Muluwork Getahun, Getu Diriba, Michael Hailu, Amanuel Wondimu, Ayinalem Alemu
… to summarize the proportion of lineages and sublineages by drug resistance profile and TB type. **METHODS:** The results were reported in accordance with the PRISMA guidelines. The study protocol was registered with ID CRD42024498336. Studies reporting Mtb lineages and sublinea…
Janmejaya Samal, Ranjit Kumar Dehury, M Benson Thomas, Hari Singh
…r quality of life, low medication adherence, progression to drug-resistant tuberculosis, and ultimately, mortality. **OBJECTIVES:** This study aimed to estimate the pooled prevalence of depression in TB patients and identify the predictors of depression in this population in Ind…
Hanie Sakhi, Maryam Meskini, Mojgan Sheikhpour
…al infectious diseases worldwide, with rising cases of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Bedaquiline (BDQ)-containing regimens have become important for the treatment of MDR/XDR-TB, and resistance to BDQ is increasing. Understanding genetic m…
David J Horne, Jerry S Zifodya, Adrienne E Shapiro, Elizabeth Chandler Church, Jonah S Kreniske, et al.
…est that simultaneously detects tuberculosis and rifampicin resistance. This review updates a comparative accuracy Cochrane review of Xpert MTB/RIF and Xpert Ultra as Xpert Ultra has replaced Xpert MTB/RIF. **OBJECTIVES:** To determine the diagnostic accuracy of Xpert MTB/RIF Ul…
Mamta Choudhary, Mamta, Pushpa
Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) continues to present critical public health and individual challenges, especially in high-burden settings such as India. Despite advancements in diagnostics and therapeutics, individuals affected by MDR/…
Maja L Brinch, Andrea Palladino, Jeroen Geurtsen, Thierry Van Effelterre, Lorenzo Argante, et al.
**BACKGROUND:** In the fight against antimicrobial resistance, mathematical transmission models have been shown as a valuable tool to guide intervention strategies in public health. **OBJECTIVE:** This review investigates the persistence of modelling gaps identified in earlier s…
Taha Maatoug, Farah Seedat, Eman Elafef, Anissa Ouahchi, Ali Mtiraoui, et al.
… 86.5 %) and predominantly male (sex ratio: 1:5). Drug-resistant TB was more common among migrants, though this was not always statistically significant (multi-drug-resistant TB: pooled OR 1.2; 95 % CI 0.9-1.6; I = 40.2 %), while extrapulmonary TB wa…
Malika Idayat, Elena von der Lippe, Nailya Kozhekenova, Oyunzul Amartsengel, Kamila Akhmetova, et al.
…/RIF, 89-96% sensitivity and 98% specificity for rifampicin resistance). Diagnostic turnaround times ranged from hours (molecular) to weeks (conventional). Only 58% of TB facilities had GeneXpert technology, with urban-rural disparities in diagnostic access. Drug-resistant TB imp…
Alfred Ngwira, Samuel Manda, Esron Daniel Karimuribo, Sharadhuli Iddi Kimera
…fects the cattle economy in Africa, with zoonotic TB posing drug-resistance issues in humans. The burden of TB in cattle and zoonotic TB in humans in sub-Saharan Africa (SSA) is not well understood. This study aimed to determine the prevalence of both TB in cattle and zoonotic TB…
Omayma Benbrik, Oumaima Bounar, Imad Chakri, Laila Lahlou, Hind Serhane
…a random-effects model. Subgroup analyses were performed by drug-susceptibility status and treatment history. Heterogeneity was assessed using the I² statistic, and risk of bias was evaluated using Joanna Briggs Institute Critical Appraisal Checklists of prevalence and case …
Heda Melinda Nataprawira, Intan M W Dewi, I Gusti Agung Ayu Novi Wiraningrat, Citra Cesilia
…of the literature on the differences in imaging findings in drug-resistant (DR) and drug-sensitive tuberculosis (DS TB) children and adolescent TB survivors. **METHOD:** We performed a systematic review to determine imaging patterns of DR and DS TB in children and adolescent sur…
Seyyed Mohammad Amin Mousavi-Sagharchi, Mina Rezghi Rami, Hanieh Hasani, Maede Mohammad Ghasemi, Maryam Farahhal, et al.
…or global health challenge, exacerbated by the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Limitations in current antibiotic therapies have intensified interest in alternative antimicrobials, including plant-derived phytochemicals. Essential oi…
Rebecca Thomas, Nicola L Harman, Paula R Williamson, Laura Bonnett, Geraint R Davies, et al.
…en of tuberculosis (TB) remains high, and treatment of both drug-susceptible and drug-resistant diseases is complex and prolonged. International clinical trial networks and public-private partnerships are beginning to deliver advances in TB treatment, and collaborative data-shari…
Zipporah Dery, Celso Pagatpatan, Margel Bonifacio
…nt adherence. The review will include studies that focus on drug-sensitive tuberculosis, drug-resistant tuberculosis, and latent tuberculosis infection, as well as studies on patients with tuberculosis and common comorbidities, such as diabetes or HIV. **METHODS:** This review w…
Md Zamiur Rahaman, Tahmina Alam, Syeda Shamsun Nahar, Ridwana Nahrin, Israt Jahan Bushra, et al.
…is reported in several regions. Treatment success rates for drug-sensitive TB reached up to 97%. New regimens incorporating bedaquiline and delamanid for multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB) showed cure rates as high as 94.6%. **CONCLUSION:** O…
Mengistu Abayneh, Ahmed Zeynudin, Yared Alemu, Teshome Degefa, Abdulhakim Abamecha, et al.
…f TB infections, with an emphasis on reducing the spread of drug- resistant TB strains.
Mohamad Faisal Said Al Omar, Izz Eddin Majed Alchikhsuliman, Sondos Mahmoud Awad, Numa Rajab, Yousef Mohammed Alawi, et al.
Novel anti-tuberculosis (TB) drugs have been shown to effectively treat drug-resistant TB (DR-TB). However, there is a risk of hepatotoxicity. We aimed to evaluate the incidence of hepatotoxicity in TB patients receiving bedaquiline (BDQ), delamanid (DLM), and/or pretomanid (Pa).…
Mikashmi Kohli, Leeberk Raja Inbaraj, Angela Salomon, Katie Scandrett, Alexei Korobitsyn, et al.
…ection of Mycobacterium tuberculosis complex and rifampicin resistance in sputum. To extend our previous review on extrapulmonary tuberculosis, we performed this update to inform a WHO policy update. **OBJECTIVES:** To estimate the diagnostic accuracy of LC-aNAATs for extrapulmo…
Alberto Matteelli, Sofia Lovatti, Benedetta Rossi, Luca Rossi
Multidrug-resistant tuberculosis (MDR-TB), the deadliest form of tuberculosis (TB), has been included in the 2024 World Health Organization (WHO) priority list of antibiotic-resistant bacterial pathogens owing to its severe public health implications. Almost two billion people wo…
Alexander W Kay, Maia Madison, Katie Scandrett, Tara Ness, Pauline Amuge, et al.
…t detects Mycobacterium tuberculosis complex and rifampicin resistance. This is an update of a Cochrane review first published in 2020 and last updated in 2022. Parts of the current update informed the 2024 WHO updated guidance for the diagnosis of tuberculosis. **OBJECTIVES:** …
Marta Kučerová-Chlupáčová
…global health threat, exacerbated by the emergence of multi-drug-resistant strains. The search for novel therapeutic agents is critical in addressing this challenge. This review systematically summarizes the potential of oxadiazole derivatives as promising candidates in antimycob…