Showing 1–25 of 73 documents
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Ayushi Sharma, Gyanendra Singh, Rahul Shrivastava
Tuberculosis is a global emergency. Despite two decades of intense research to understand and cure the disease, biological uncertainties prevail and hamper the therapeutic progress. Increasing incidences of multidrug-resistant (MDR) and extensively drug resistant (XDR) Mycobacter…
Vaishnavi Vivekanandan, Arun K, Sindhu Hasini Doredla, Harini Ramanujam, Ranjani Singaraj, et al.
Tuberculosis (TB), caused by members of the Mycobacterium tuberculosis complex (MTBC), remains a significant global health concern. While zoonotic transmission of M. bovis from cattle to humans is well documented, reverse zoonotic transmission of M. tuberculosis from humans to ca…
Lynn Sosa, Lloyd N. Friedman
…he treatment facility. The usual therapy for drug-sensitive tuberculosis (TB) comprises four drugs for 2 months, dropping ethambutol once the organism is known to be sensitive to isoniazid, rifampin, and pyrazinamide; then continuing maintenance isoniazid and rifampin for 4 month…
Kashish Choudhary, Sana Tanweer, Mohd Zaid Choudhary, Sonam Grover
Tuberculosis (TB) is a health concern resulting in 10.8 million cases every year. In 2024, TB had the highest fatalities second only to COVID-19. Global TB management has become difficult due to rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) TB. Therefore…
Francesca Saluzzo, Andrea Maurizio Cabibbe, Richard Anthony, Alexandra Aubry, Francis Drobniewski, et al.
…rted poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require adaptatio…
Jingxian Ning, Rong Wang, Yuchen Pan, Xinru Fei, Wenxin Jiang, et al.
**OBJECTIVE:** Tuberculosis significantly affects human health and longevity. We aimed to systematically synthesize studies to summarize the median survival time range and years of potential life lost (YPLL) among tuberculosis patients. **METHODS:** We searched Web of Science, P…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
The emergence of drug-resistant tuberculosis jeopardizes the TB control programme activities globally. Multidrug-resistant TB is defined as tuberculosis strains resistant to at least two first-line drugs, rifampicin (RIF) and isoniazid (INH). Extensively drug-resistant TB refers …
Pauline Howell, Jonathan Stillo, Anja Reuter, Tendai Nkomo, Carole D Mitnick, et al.
Drug-resistant tuberculosis is entering a new and dangerous phase. Bedaquiline and other newer drugs have transformed drug-resistant tuberculosis treatment, yet resistance to these agents is now being reported across high-burden settings. In some regions, baseline bedaquiline res…
Supriya Mallick, Manish Shankar, Satyadeo Choubey, Arshad Ejazi, Rakesh Kumar, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis continues to be a major threat to mankind and is a major social and economic burden to society. Line probe assay (LPA) is a method for detecting Mycobacterium tuberculosis (MTb) in combination with resistance to rifampicin and ison…
Yang Zhang, Ruiying Wu, Mingrui Sun, Xiaotian Li, Ren Fang, et al.
Tuberculosis, a chronic infectious disease caused bycomplex, has re-emerged as the leading cause of death worldwide as a single infectious agent. The increasing prevalence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis poses a severe and growing t…
Ying Wang, Daxing Cao, Guihua Liu
Treatment regimens for Tuberculosis (TB) primarily rely on first-line drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. Although these drugs have been pivotal in the treatment of drug-resistant tuberculosis, their high costs limit widespread use in low- and middl…
Piyushkumar Sadhu, Mamta Kumari, Niyati Shah, Chitrali Talele, Nirmal Shah, et al.
Drug-resistant tuberculosis, particularly those with rifampicin resistance (RR-TB), has emerged as one of the major challenges to the goal of eliminating tuberculosis. Additionally, three or four different medications must be used in an effort to treat TB, but sadly, there aren't…
Anjali Saxena, Summer Bhagra, Shuvayoo Das, Naveen Kaushik, Biswajit Saha
…drug-resistant and extensively drug-resistant strains of M. tuberculosis. The escalating prevalence of multidrug-resistant and extensively drug-resistant strains, compounded by the pathogen's extraordinary capacity to survive within host macrophages and pharmacologically impenetr…
Joséphine Khady Badiane, Zelika Harouna Hamidou, Abdou Padane, Rita Zgheib, Hamadou Oumarou Hama, et al.
… 49 sub-Saharan African countries, which account for 85% of tuberculosis cases in Africa (WHO, 2025), to monitor the genomic dynamics of Mycobacterium tuberculosis complex strains responsible for the disease was examined for the period 2000-2025. A total of 8141 GenBank entries, …
Roopendra Kumar, Jagdeep Singh Sohal, Ajay Vir Singh, Devendra Singh Chauhan
… nonresponsive multidrug-resistant (MDR) cases of pulmonary tuberculosis (TB). It offers new hope in the global fight against drug-resistant TB, which remains a major health challenge. However, the pursuit of better treatment outcomes has been confronted by the rapid emergence of…
Tuberculosis (TB), especially the multidrug-resistant tuberculosis (MDR) and extensively drug-resistant (XDR) forms, is a major global public health threat due to its complexity of treatment regimens as well as the widespread resistance to tuberculosis.The rise of MDR-TB, defined…
Mousumi Saha, Indrani Sarkar, Arnab Sen
…gnificant role in the evolutionary study of these bacteria. Tuberculosis, a noxious bacterial disease caused by M. tuberculosis, has infected a large section of the population throughout the world, including India. M. tuberculosis is the most successful pathogen of this genus tha…
Vaishali N. Pardeshi, Tushar Lokhande, Khemchand R. Surana, Ashwini Shelke, Yogita B. Thombare
Tuberculosis (TB) is still a significant public health issue across the world, especially with the advent of multidrug-resistant TB. The incapacity of humans to manage this illness derives from the fact that formerly successful TB vaccinations and treatments are no longer effecti…
Pulak Pritam, Sreelipta Das, Sandeep Kumar Behera, Monali Sahoo, Lopamudra Subudhi, et al.
The disease tuberculosis, caused by, is one of the leading causes of global human mortality. The rise of multidrug and extensively drug-resistant strains of the pathogen and the limited efficacy of the BCG vaccine is one of the major concerns worldwide. Conventional chemotherapy …
Koushik Mukherjee, Pritam Saha, Kirat Kumar Ganguly, Somjyoti Chakraborty, Swarnali Ghosh, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global health threat. Despite advances in diagnostics and treatment regimens, it infects millions annually. It remains a significant global health challenge, particularly due to the appearance of resistance towar…
Rachana Khati, Alok Kumar Paul, Maria de Lourdes Pereira, Mohammed Rahmatullah, Veeranoot Nissapatorn, et al.
… the ancient period, the pathogenic bacterium Mycobacterium tuberculosis has been affecting mankind and has become a cause of contagious disease—tuberculosis. However, to globally overcome the health issues against MDR and XDR TB, there is an urgency to streamline more inputs for…
Agata Maciejak-Jastrzębska, Grażyna Sygitowicz, Sylwia Brzezińska, Kinga Bielska, Ewa Augustynowicz-Kopeć
Tuberculosis (TB), caused by, remains a global health problem. One of the characteristic features of mycobacteria is their exceptional resistance to environmental factors and their slow growth rate, both of which significantly prolong microbiological diagnostics. Due to the morta…
Krupanshi Bharadava, Aviral Kaushik, Nigam Vyas, Tarun Kumar Upadhyay, C. Ratna Prabha, et al.
Tuberculosis (TB) is a highly contagious and potentially life-threatening infectious disease caused by the bacterium <i>Mycobacterium tuberculosis</i> (MTB). Despite significant progress in medical science, TB remains a global health concern, affecting millions of peo…
Rafael Laniado-Laborín
Despite recent advances in the pharmacologic treatment of tuberculosis, some patients are left with residual or persistent sequels that could benefit from surgical intervention. Most experts believe that surgical treatment is rarely necessary in patients with pansensitive tubercu…
Rafael Laniado-Laborı́n
…drug susceptibility testing. The presence of drug-resistant tuberculosis should be suspected in patients who are failing treatment, in patients with TB relapse, in subjects coming from regions with a high prevalence of MDR-TB, and in contacts of known cases of MDR-TB. Although th…