Vitamins as Nutraceuticals for Tuberculosis

Tuberculosis (TB) is still a significant public health issue across the world, especially with the advent of multidrug-resistant TB. The incapacity of humans to manage this illness derives from the fact that formerly successful TB vaccinations and treatments are no longer effective. As a result, researchers are looking for novel anti-tuberculosis drugs and adjuvant treatments. Vitamins are being studied again for their involvement in pathogenesis and anti-mycobacterial effects. Vitamins like biotin and thiamin are necessary for Mycobacterium TB to form an infection. Vitamins like Vitamin C and Vitamin D, on the contrary, have been demonstrated to have anti-mycobacterial effects. Innovative techniques must be designed to battle M. tuberculosis, keeping the effectiveness of the drug in mind. Vitamins 22may show to be effective agents for altering M. tuberculosis’ life cycle and biology. Pyridoxine (vitamin B6) is recommended by the WHO when isoniazid at a high dose is used. Vitamin C sterilizes drug-susceptible, MDR, and MTB that is extensively drug-resistant cultures, preventing the formation of persistent drug users; vitamin D inhibits mycobacterium multiplication in vitro; and vitamin E has a prospective function in TB management due to its link to oxidative equilibrium. We present here a brief overview of the available knowledge on Vitamin-B complex, Vitamin C, Vitamin D, Vitamin E, and Vitamin K keeping TB treatment and control in perspective.