Showing 1–25 of 200 documents
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Kara Lukas, Madeleine T Dang, Clare Necas, Vishwanath Venketaraman
…uberculosis (TB) is a global health challenge caused bywith drug resistance, treatment toxicity, and treatment adherence challenges continuing to impede control efforts. The objective of this review is to explore current advancements in TB treatment, for both drug-sensitive and d…
Tanzila K. Chowdhury, Laurence A. F. Park, Glenn Stone, Mark M. Tanaka, Andrew Francis
…lly and is exacerbated by a growing problem with antibiotic drug resistance. To control the spread of such resistance, it is important for public health authorities to know whether drug-resistant strains in their population have arisen from the ineffective treatment of a previous…
Erfaneh Jafari, Reza Azizian, Mohsen Tabasi, Morteza Banakar, Kamran Bagheri Lankarani
… by, remains a major global health burden. The emergence of drug-resistant strains presents a critical challenge in TB management. The recent research has explored the interaction between TB and the human gut bacteriophage community (phageome). The gut phageome plays a crucial ro…
Shuying Zhang, Juan Cheng, Yuanyuan Tang
Drug-resistant(Mtb) has become a global public health crisis, and its diverse drug resistance jointly reduces the effectiveness of antibacterial drugs. Mtb resistance is not merely genetic but involves a synergistic interplay of cell wall remodeling, metabolic reprogramming, and …
Mehdi Roshdi Maleki
…h due to infectious disease. Additionally, the emergence of drug-resistant strains has created a significant challenge for the treatment of this disease. Approximately 25% of TB-related deaths are attributed to antimicrobial drug resistance. Various mechanisms contribute to the d…
Drug-resistant tuberculosis is a re-emerging public health concern which requires special attention all around the world.Among all the infectious diseases, drug-resistant tuberculosis is now the most lethal infection causing disease in both children and adults.The co-infection of…
Carolina H Chung, Rupa Bhowmick, Annie J Badenoch, Harkirat S Arora, Sriram Chandrasekaran
Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutions. Recent research suggests that bacteria and cancer cells reprogram their metabolism and manipulate their external metabolic environment to resist a diverse range of therapeutics…
Sabina Gałka
Drug resistance in bacteria and fungi is a global threat to public health. The purpose of this publication is to review the latest scientific achievements, mainly from 2020-2025, concerning the use of hemp compounds from Cannabis sativa in combating drug-resistant bacterial and f…
Alex Odoom, Abdul-Halim Osman, Christian K O Dzuvor
Antimicrobial resistance poses a grave threat to global public health. Although new antibiotics are urgently needed, most share resistance mechanisms with existing drugs, thereby necessitating the development of alternative antibacterial therapeutics. Various immunotherapeutic ag…
Mohammed Alfaqeeh, Prayudi Santoso, Jan-Willem Alffenaar, Ivan S Pradipta
Drug-resistant tuberculosis (DR-TB) continues to be a major global health threat, and while advancements in drug therapies have been made, the role of pharmacists in improving patient outcomes has not been fully optimized. This review aims to describe the types, resistance mechan…
Jessica Renz, Kazeem A Dauda, Olav N L Aga, Ramon Diaz-Uriarte, Iren H Löhr, et al.
…t the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology and in applied approaches to address the global health challenge of antimicrobial resistance (AMR). In this minireview, we discuss…
Akhil Sharma, Vikas Sharma, Shivika Sharma, Sonu Sharma, Monu Sharma, et al.
…ions of conventional treatments and the rising incidence of drug-resistantstrains. This review consolidates the advancements in nanotechnology-based therapeutics, inhalable formulations, CRISPR-Cas tools, host-directed therapies (HDTs), and nanoparticle-based vaccine development …
Sungwon Jung
…es the gap between point-of-care rapid tests and phenotypic drug susceptibility testing (pDST) in drug-resistant tuberculosis (DR-TB). The 2025 World Health Organization (WHO) consolidated guidelines and the operational handbook place tNGS after initial automated nucleic acid amp…
William R McManus, Katie Mulvey, Jeffrey S Schorey
…important aspect of their pathogenesis and known antibiotic resistance. In this review, we discuss the pathogenesis of this important mycobacterial species, what we know of its ability to form biofilmsandand gaps in our knowledge of these processes. We also discuss how we may lev…
G. Mac-Fiberesima, SD Abbey, C. K. Wachukwu, O. Azuonwu
Tuberculosis is a life-threatening infectious disease that is responsible for the death of most people all over the world. It is characterized by coughing, fever, night sweats and loss of weight due to the pathology of Mycobacterium tuberculosis that causes the disease. In some c…
Karuna Gokarn, Ramprasad B. Pal
Background: The problem of drug-resistant Mycobacterium tuberculosis (M.tb) is alarming and therefore there is an immediate need for alternative or complementary drugs. This could be achieved by repurposing existing FDA-approved drugs. In this study, the anti-tuberculosis activit…
Sadia Asif, Ashik Francis, Emmanuel Ijabani, Anil Thakur
…ise of new fungal pathogens and the alarming spread of multidrug resistance in species such as Candida auris, Candida glabrata, Aspergillus fumigatus, and Cryptococcus neoformans. Resistance to antifungal drugs is complex, arising from natural resistance traits, genetic mutations…
Seyed Mehdi Hosseini, Narjes Morovati Moez, Mohammad Reza Arabestani
…ruse and abuse of prescription antifungal and antibacterial drugs, which causes organisms to gradually acquire the ability to overcome the drug and develop resistance. Moreover, many antimicrobials display a variety of toxicities for human use. Also, multiple resistance of bacter…
Evelina Lesnic, Alina Malic
The culture with the drug susceptibility testing are the gold standard in diagnosis of tuberculosis (TB). However the use of the new molecular genetic test for identification of Mycobacterial tuberculosis DNA based on polymerase chain reaction contributed to earlier diagnosis of …
Sarita Rani, Ankur Kaul, Anil Kumar Mishra, Umesh Gupta
…thogenesis, types, diagnosis tests, emergence of MDR (multi drug resistance) and XDR (extensively drug resistance). The traditional chemotherapy of TB includes first and second line drug therapy. These lines of therapies face many difficulties such as low solubility, low bioavail…
Ye Myat, Chris Orton, Hannah Jarvis, Onn Min Kon
…improve diagnostic accuracy and ability to quickly identify resistance patterns. Standard treatment choices and route of administration may need to be modified given uncertain enteral absorption and concerns over drug interactions and drug resistance. Infection control measures c…
Onix Cantres-Fonseca, Francisco Del Olmo-Arroyo
…ce rest in worldwide prevalence, pathogen spread, treatment resistance and the need for eradication. Drug treatment resistance is considered as one of the criteria to prioritize a country in the World Health Organization’s intention to eradicate tuberculosis infection in the worl…
Siqi Lin, Qianqian Zhang, Juan Liu, Bojie Lin, Daina Zhao, et al.
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), coupled with lengthy treatment cycles and adverse side effects of traditional therapies, poses a significant global challenge in the form of tuberculosis (TB). Photodynamic therapy (PDT) generates reacti…
C. M. Divyashanthi, S. Kumar, N. P. Bharathi
Background: Antimicrobial drugs includes all agents that work against a variety of microorganisms such as bacteria, viruses, fungi and parasites. Antimicrobial resistance is when bacteria or other microbes become resistant to the effects of a drug after being exposed to them. Bac…
Wei Zhang, Qing Wang, Liru Zhang, Jiangxiong Wu, Jinlu Liu, et al.
…lated Escherichia coli from 2014 to 2022. Methods: In vitro drug sensitivity of E. coli to 20 antibiotics was examined using the microbroth dilution method. A total of 7580 clinical E. coli strains were isolated from 2014 to 2022, among which 56.9% were identified as extended-spe…