Showing 1–25 of 200 documents
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Rahma Isti Kusyadi, Lita Diah Rahmawati, Prastuti Asta Wulaningrum
**INTRODUCTION:** Poncet's disease (PD) is a rare form of TB-associated reactive arthritis, presents a major diagnostic challenge due to its close resemblance to rheumatoid arthritis and tuberculous septic arthritis. A clear diagnostic workflow is essential to support clinical de…
Juan José Villamarín Marrugo, Juan Manuel Naranjo Piñeros, Erwin Hernando Hernandez Rincon
**RATIONALE AND OBJECTIVES:** Access to diagnostic imaging in low- and middle-income countries (LMICs) is limited by scarce equipment, geographic barriers, weak digital infrastructure, and shortages of trained personnel. Artificial intelligence (AI) has emerged as a promising too…
Emily A Kendall, Claudia M Denkinger, Adithya Cattamanchi, David W Dowdy, Jason R Andrews
…ponent tests. Therefore, when evaluating novel tuberculosis diagnostics, greater consideration should be given to characterising which segments of the disease spectrum are detected, how these segments overlap across tests, and how they are prioritised for detection. Understanding…
Maria Helena Favarato, Victoria Luisa Pereira Aguiar, Edison Ferreira Paiva, Leonardo Oliveira Mendonça
**BACKGROUND AND METHODS:** Recurrent fever is a complex clinical presentation that poses significant diagnostic challenges, particularly when no clear etiology emerges despite extensive investigation. This integrative narrative review provides a comprehensive overview of recurre…
Derong Kong, Zhenzhen Xu, Chang Chen, Yunqi Liu, Dacheng Wei
…(POC) testing holds great promise for transforming clinical diagnostics by enabling rapid, convenient, and accurate analysis outside of centralized laboratories. Among various emerging technologies, biological field-effect transistors (bio-FETs), which directly convert molecular …
Patrycja Olszewska, Monika Spietelun, Katarzyna Syguła, Andrzej Ossowski, Bartłomiej Grygorcewicz
…fically infect bacteria, have emerged as a valuable tool in diagnostics due to their unique specificity and adaptability. This review explores the diverse applications of bacteriophages in diagnostic methods, from traditional phage typing to advanced molecular techniques such as …
Nora Engel
This chapter examines attempts to innovate TB diagnostics for the point of care, aimed at improving diagnosing in resource-constrained settings and cutting diagnostic delays. Drawing on ongoing and past fieldwork from global to local levels, the analysis contrasts challenges of e…
Norbert Georg Schwarz, Ulrike Loderstaedt, Andreas Hahn, Rebecca Hinz, Andreas Erich Zautner, et al.
…uld not preclude developing countries from state of the art diagnostics.
Mainak Ghosh, Monali Lahiri, Aman Dalal, Kishan Kumar Parida, Nitin Pal Kalia
… for successful management of the disease. The conventional diagnostics includes staining, microscopy, tuberculin skin test and chest X ray. However, they have various limitations which increases the public threat. These tools lack the ease of transportation, less sensitive, time…
Moustafa Kardjadj
Point-of-care (POC) infectious disease diagnostics are reshaping global health by delivering rapid, decentralized, and clinically actionable results that link bedside testing to population-level surveillance. Valued at approximately USD 53 billion in 2024 and projected to nearly …
Cemre Arpa, Ahmed Abd El Wahed, Serap Aydin, Prakash Ghosh, Dinesh Mondal, et al.
…globally. Non-specific symptoms and limitations of existing diagnostics involve challenges for informed policymaking and clinical practice. This paper reviews common practices in reporting the selection and definition of cost and effect parameters, and in reporting the translatio…
Leah Argus, Vijay Sharma, Christopher Darlow, Kavita Sethi, Iain Lyburn, et al.
**AIMS:** Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory breast condition of unknown aetiology. It is a diagnosis of exclusion with a wide differential diagnosis. To date, no diagnostic guidelines exist for IGM in the UK. This scoping review aims to evalua…
Rajesh Sarkar, Tadesse Shume, Tewodros Tesfa
…diagnosis of disease for many decades. Host biomarker-based diagnostics identify particular biological markers in a patient's body, such as proteins, metabolites, or nucleic acids that signify the existence, intensity, or kind of disease. Clinical diagnosis depends significantly …
Xiao Dong, Chao Xie, Zhe Zhang, Hongjian Ye, Ruihua Liu, et al.
Peritonitis caused by atypical and rare pathogens is challenging to diagnose. Although the International Society for Peritoneal Dialysis (ISPD) guidelines significantly improve the diagnostic rate by placing peritoneal dialysis fluid into blood culture bottles, peritonitis caused…
Karthikeyan Sundaram, Sridhar Rathinam, Venkataraman Prabhu
Tuberculosis and systemic fungal diseases are opportunistic and challenging to diagnose. However, in immunocompromised people, especially people living with human immunodeficiency virus (PLHIV), the signs and symptoms of both diseases highly imitate each other. Primarily, chronic…
Dr Rashmi Dixit, Dr Sonali Garg, Dr Gaurav Shanker Pradhan
Pott's spine is associated with high morbidity, long-term disabling sequelae and even mortality. The classical paradiscal form, where there is destruction of end plates of adjacent 2-3 vertebral bodies along with intervening disc involvement and associated paravertebral abscess i…
Christian Görg, Yi Dong, Görg Friedemann, Christian Jenssen, Michael Kallenbach, et al.
Necrotizing (abscessing) lymphadenopathy is a clinically relevant condition with a broad differential diagnosis, including acute bacterial infections, mycobacterial disease, zoonoses, fungal and parasitic infections, autoimmune disorders, and malignancies with central necrosis. E…
Eamonn Gormley, David E MacHugh, Kieran G Meade
As a zoonotic disease, with a global impact on animal health, welfare and trade, bovine tuberculosis (bTB), caused by infection with Mycobacterium bovis, has been subject to strict control measures in many countries to reduce the impact of the disease on cattle and their handlers…
Isil Aksan Kurnaz, Ekin Sonmez, Augustine Ovie Edegbene, Gergely Toldi, Muhammad Qasim, et al.
…tious diseases worldwide. Despite advances in treatment and diagnostics, challenges such as multidrug resistance, inadequate vaccines, diagnostic gaps and health inequities continue to impede global control efforts. This review explores emerging insights into host-pathogen intera…
Tobias Broger, Mark P. Nicol, Rita Székely, Stephanie Bjerrum, Bianca Sossen, et al.
Traditional diagnostic methods, such as culture or smear microscopy, are slow or low in sensitivity. More sensitive modern techniques, such as Xpert MTB/RIF, require a certain infrastructure, are costly, and are not widely accessible. Diagnostic accuracy was determined separately…
Pierre Goussard, Ernst Eber, Lisa Frigati, Leonore Greybe, Shyam Sunder B Venkatakrishna, et al.
**OBJECTIVES:** To investigate the role of both diagnostic and interventional paediatric bronchoscopy in the management of respiratory diseases in children in low- and middle-income countries (LMICs). **DESIGN:** A review of published English literature from January 2014 to Febr…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Muthuraj Muthaiah
…berculosis (TB) is a priority for global TB control. Molbio Diagnostics has developed the TrueNat point-of-care molecular assays for detecting TB and rifampicin (RIF) resistance. Until 2020, the Xpert system was the only WHO-recommended option for rapid molecular detection of bot…
Ewelina Szacawa, Łukasz Radulski, Marcin Weiner, Krzysztof Szulowski, Monika Krajewska-Wędzina
Thecomplex (MTBC) represents one of the most significant bacterial pathogen groups affecting both animals and humans worldwide. This review provides a comprehensive analysis of MTBC species distribution across different animal hosts and evaluates current laboratory diagnostic met…
Md. Abir Tazim Chowdhury, Munama Magdum
This chapter will discuss bronchopulmonary actinomycosis and our clinical recommendation with the literature review. Actinomycosis is a disease caused by filamentous Gram-positive anaerobic bacteria of the genus Actinomyces. It is a rare and slowly progressive infectious disease …
Wiem Feki, Amal Chakroun, Amina Kammoun, Fatma Hammami, Khaoula Rekik, et al.
**PURPOSE:** Infectious sacroiliitis (ISI) is a rare condition with non-specific symptoms, often leading to delayed diagnosis We aim to describe the clinical, microbiological, and radiological characteristics of infectious sacroiliitis (ISI), and to highlight the diagnostic and f…