Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Fangzheng Guo, Yamin Song, Sihang Dong, Jing Wei, Baiqing Li, et al.
Tuberculosis (TB) is a chronic infectious disease caused by(Mtb) that poses a severe threat to human health. A variety of highly immunogenic tuberculosis proteins have been used as targets in vaccine development to mitigate the spread of TB. Although Th1-type immunity has long be…
Seán Donohue, Gina Leisching, Joseph Keane
Greater understanding of the immunopathogenesis of tuberculosis is critical for developing novel therapies. Here, we propose that immunothrombosis plays an important role in the immune response to Mycobacterium tuberculosis. This interplay among macrophages, neutrophils, and plat…
Pınar Ergenekon, Arif Kut, Nader Fasseeh
Tuberculosis (TB) is a serious public health problem affecting the entire globe. Despite the fact that Mycobacterium tuberculosis (MTB) vaccine was invented a long time before, MTB is even today one of the most widespread causes of mortality due to a single infectious factor [1, …
Dinara Adjablaeva
…ameters of children and adolescents with different forms of tuberculosis. Laboratory and instrumental methods of examination of patients do not cover all aspects of tuberculous infection and do not allow valuing the condition of children and adolescents with pulmonary tuberculosi…
Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Mycobacterium tuberculosis remains one of the world's most persistent pathogens, responsible for over a million deaths each year despite effective drugs and decades of research. Disease progression varies widely among individuals, reflecting interactions between pathogen, physiol…
Meng-Yuan Lyu, Hong-Li Lai, Hao-Ran Peng, Han Luo, Jian Zhou, et al.
The worldwide dissemination of drug-resistant tuberculosis (TB) presents significant obstacles to conventional anti-TB treatment and prevention methods based on bactericidal antimicrobial drugs, greatly impeding advancements in combating this most lethal disease. With growing ins…
Marco Silva, Alexandre J Pinto, Tiago Beites
…ironment. In this context, the human pathogen Mycobacterium tuberculosis is an interesting example. Despite being an obligate pathogen that has been co-evolving with the human host for millennia, M. tuberculosis genome retains redundant functions at multiple levels that allow the…
Abayomi S Faponle, James W Gauld, Sam P de Visser
…l, adaptability and pathogenicity.is the causative agent of tuberculosis, an infectious disease that affects millions of people globally. Common anti-tuberculosis targets are focused on immobilizing a vital cysteine amino acid residue in enzymes that plays critical roles in redox…
Tuberculosis (TB) infects one-third of the world population, and more than 80% of patients with active tuberculosis are HIV positive and at high risk of developing active disease. Intraocular TB constitutes a very small percentage of uveitis cases in North America and Europe (abo…
Ramya Gopinath, Suthandira Munisamy, M. Jeyadevasena, Jacobson Jeffrey, Elanchezhiyan Manickan
…staining and smear microscopy employed for the diagnosis of tuberculosis (TB) have a significant disadvantage of poor sensitivity and the gold standard diagnostic method employing culture is time-consuming. This study was conducted to isolate and identify Mycobacterium tuberculos…
Mohammad Nasir, Samreen Ahmed, Mohammad Shameem, Kaif Siddiqui, Azmat Karim
The 26.07 lakh reported cases of Tuberculosis (TB) in 2024 render India's target of eradicating TB under the National Tuberculosis Elimination Programme a distant dream. Nonetheless, by leveraging Artificial Intelligence (AI), India can chase the United Nations' 2030 target. A ma…
Haiqi Chen, Abulimiti Abudukadier, Qi'ao Zhang, Peibo Li, Jianping Xie
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), constitutes a major global health challenge. The pathogenesis of Mtb can be largely attributed to its sophisticated survival strategies within host macrophages. Methylglyoxal (MGO), a ubiquitous reactive dicarbonyl me…
Mainak Ghosh, Monali Lahiri, Aman Dalal, Kishan Kumar Parida, Nitin Pal Kalia
Tuberculosis (TB) is one of the major life-threatening diseases caused by a single pathogen which has become a social menace owing to its high resistance. TB has even surpassed AIDS prior the COVID 19 pandemic. Every year the number of affected persons is increasing exponentially…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Future research on Mycobacterium tuberculosis (Mtb) proteins is essential for advancing tuberculosis (TB) diagnosis, treatment, and control amid rising drug resistance and global health challenges. Recent studies focus on elucidating protein structures and interactions critical t…
Ritu Raj Patel, Vidyasagar, Sudhir Kumar Singh, Meenakshi Singh
Despite being a preventable and treatable disease, tuberculosis (TB) remained the second leading infectious cause of death globally in 2022, surpassed only by COVID-19. The death rate from TB is influenced by numerous factors that include antibiotic drug resistance, noncompliance…
Cui Bao, Yuanyuan Zhang, Jiao Feng, Xiuwen Hong, Nan Gao, et al.
Tuberculosis is a widely spread disease caused by(Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes critically regulate tuberculosis infection. When Mtb …
Zhengshu Ye, Zeliang Yang, Jiachang Zhang, Ying Wang, Xinting Yang, et al.
Mycobacterium tuberculosis (Mtb) is the primary pathogen that causes tuberculosis in humans. As the primary target cells, macrophages employ reactive oxygen species (ROS) as a crucial defense against Mtb. However, the dynamic and reciprocal interplay between Mtb, macrophages, and…
Yingxiao Han, Songwei Ma, Rui Ma, Jingjing Li, Lei Qiu, et al.
Mycobacterium tuberculosis culture filtrate proteins (MTB-CFPs) are critical for tuberculosis diagnosis and vaccine development. To explore their diagnostic potential, MTB was statically cultured in Sauton's medium for 15 days; MTB-CFPs were collected, fractionated using six…
Diwakar Singh
Mycobacterium tuberculosis, which causes TB, is a serious global health problem. Protein kinases are essential for controlling many cellular functions, including the induction of immune response to pathogens. Now a day TB strains that are getting more and more drug resistant is a…
Onix Cantres-Fonseca, William Rodríguez-Cintrón, Francisco Del Olmo-Arroyo, Stella Baez-Corujo
Mycobacterium tuberculosis is the bacterium that as a single agent is known to cause the infection with the most morbidity and mortality around the world. It is known to cause pulmonary infection in immunocompetent patient, but its dissemination outside the lungs has been linked …
Dingyuan Yan, Xue Li, Huanhuan Wang, Bin Li, Wei Wang, et al.
…anoparticle (NP) for precise phototheranostics of pulmonary tuberculosis (TB). Coating the phototheranostic agents with preactivated macrophage membranes results in the formation of biomimetic NPs, which exhibit specific binding to TB through a lesion-pathogen dual-targeting stra…
P Tejaswani, Debashis Das, Spandan Kumar, Amit Kundu, Kousar Jahan, et al.
Tuberculosis remains a deadly infectious disease with 1.09 million deaths and 10.8 million new cases reported in 2023. Escalating drug resistance and mortality rates worsen the situation. To address these issues, new TB agents with improved activity, better enzyme activation, low…
Victória Moraes-Silva, Cecília Alvim Dutra, Márcia Quinhones Pires Lopes, Philip Noël Suffys, Adalberto Rezende Santos, et al.
Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, accounts for 10 million cases worldwide per year, remaining a major problem for public health. The anti-TB drug isoniazid (INH) is recommended by the WHO. Despite of effective drugs, some individuals do not respond t…
Guiyi Ji, Yunxing Fu, Linlin Song, Rong Hu
Female genital tuberculosis (FGTB) is a major cause of infertility in regions where it is common, causing permanent damage to the reproductive tract. It mainly causes fibrosis and blockage of the fallopian tubes, directly hindering gamete movement. Meanwhile, FGTB leads to a decl…
Zahra Toossi, Larry S. Schlesinger
…tral role for mononuclear phagocytes in the pathogenesis of tuberculosis has been known for a century, the resurgence of tuberculosis in the United States and worldwide over the past two decades has lead to an equally impressive resurgence of research aimed at further defining th…