THE ROLE OF SERINE/THREONINE PROTEIN KINASES OF MYCOBACTERIUM TUBERCULOSIS IN DISEASE MANAGEMENT

Mycobacterium tuberculosis, which causes TB, is a serious global health problem. Protein kinases are essential for controlling many cellular functions, including the induction of immune response to pathogens. Now a day TB strains that are getting more and more drug resistant is a significant public health concern. The physiological function of the kinases may help to comprehend the signalling networks underlying the TB infection. Finding novel pharmacological targets that are crucial for the in vivo bacterial survival and persistence is essential for treating TB successfully. In M. tuberculosis, phosphorylation-based signalling cascades that are controlled by serine/threonine protein kinases and phosphatases that are similar to those found in eukaryotes translate extracellular cues into cellular responses that lead to the pathogen's proliferation, persistence, and disease. The M. tuberculosis genome encodes two-component systems, 11 Serine Threonine Protein Kinases (STPKs), 1 Ser/Thr phosphatase, 1 Tyrosine Kinase, and 2 Tyrosine Phosphates regulate the signalling pathways in MTB. By examining these molecules' potential as targets for therapeutic intervention and the management of diseases, these studies will close a knowledge gap.