Showing 176–184 of 184 documents
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Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Ionela Alina Grosu, Mona Elisabeta Dobrin, Corina Marginean, Irina Mihaela Esanu, Oana Elena Melinte, et al.
In recent decades, the burden of TB has been gradually declining; however, with the emergence of COVID-19 and ongoing political conflicts, including the war in Ukraine, the proper functioning of healthcare services and TB control programs has been jeopardized. Recently, research …
Mareike Rabe, Jennifer A Hughes
…an overview of current evidence and recommendations for TPT regimens (including 6H, 3HP, 3RH, 4R, 12H, and 6LFX) and their eligibility, safety considerations, drug interactions, and formulations suitable for CAPPW. By strengthening awareness and streamlining guideline-based preve…
A J Hickey, P G Durham, A Dharmadhikari, E A Nardell
Since the 1990s the rising incidence of multiple drug resistant TB, particularly in the context of human immunodeficiency virus co-infected patients, has threatened global TB control. At that time funding agencies began to support formal investigation of aerosol therapy which unt…
Ayman Elbehiry, Eman Marzouk, Adil Abalkhail
…(MDR) and extensively drug-resistant (XDR) disease; current regimens, although effective, are prolonged, toxic, and often fail to reach intracellular bacilli in heterogeneous lung lesions. This narrative review synthesizes how next-generation antimycobacterial strategies can be t…
Saroj Verma, Vaishali M Patil, Uma Agarwal
…ss the pharmacokinetics (PK), pharmacodynamics (PD), dosing regimens, and pharmacogenomics of isoniazid, along with the role of artificial intelligence (AI)/machine learning (ML) in its personalized use. In addition, we analyze NAT2 mutations and their impact on acetylation rates…
Periyasamy Vijayalakshmi, Faiz Alfaiz, Rajendran Vijayakumar, Deepali Desai, Chandrabose Selvaraj
…ment to address adaptive resistance, improve on drug dosing regimens, and improve treatment outcomes. Additionally, host-directed therapies (HDTs) and the concept of developing drugs with dual activity are suggested as possible new strategies in TB control. Holders of co-culture …
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…espite the availability of effective vaccines and treatment regimens, gaps in awareness, funding, healthcare infrastructure, and social determinants of health hinder global elimination efforts. Coordinated, multisectoral strategies are essential to address this complex epidemic, …
Salvatore Rotundo, Francesca Serapide, Gabriella d'Ettorre, Maria Teresa Tassone, Mattia Albanese, et al.
…s for TBI include isoniazid monotherapy and rifamycin-based regimens in most cases, with varying preferences across guidelines. Challenges in TBI treatment include hepatotoxicity and adherence issues, particularly among migrants. Overall, a comprehensive approach addressing socio…