Showing 151–175 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Alina Malic, Adriana Niguleanu, Tatyana Osipov
Treatment of tuberculosis (TB) includes various therapeutic regimens with a combination of at least four drugs. Adherence to the treatment regimen is crucial for efficacy outcomes based on the achievement of appropriate drug levels. Drug-resistant () strains are mainly favored by…
Anjali K Mahato, Rupal Rai, Rashmi Chourasia, Anirudh K Singh, Shivendra K Chaurasiya
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), remains a leading global health threat, exacerbated by rising drug resistance and the ability of this pathogen to persist within host macrophages. Central to the intracellular survival of M. t…
Kusum Sharma, Megha Sharma
Timely diagnosis of spinal tuberculosis is imperative to initiate appropriate therapy and to prevent long-term sequalae-like deformities. The clinical and radiological features have several mimickers, and microbiological evidence of Mycobacterium tuberculosis or its products form…
Shreya Chakraborty, Devi Rajeswari V
Tuberculosis (TB) has become the most common reason for contagious disease-related fatalities globally. Due to the estimated 8.6 million fresh tuberculosis infections and 1.6 million fatalities, this disease is a leading contributor to mortality globally. Tuberculosis refers to a…
Tirta Darmawan Susanto, Bambang Sutrisna, Asri C. Adisasmita, Annabella Vinsensa, Sapariah Anggraini
Background: Patients with chronic disease, including tuberculosis, can be easily get depressed. Valid and reliable instrument needed to detect depression in Tuberculosis patients. The Indonesian language version of Zung Self-Rating Depression Scale questionnaire is needed to be p…
Dženan Kovačić, Adna Softić, Adna Salihović, Jovana Jotanović
Tuberculosis persists among the top 10 causes of death globally; causing 1.7 million deaths and 10 million new infections in 2018. Approximately 1/3 of the global population is infected with Mycobacterium tuberculosis; 10% of which are expected to develop active TB at some point …
Thi Mai Nguyen, Emily Lai-Ho MacLean, Xiaomei Zhang, Sophia B Georghiou, Hui Xia, et al.
The paucity of diagnostic tests for isoniazid-resistant tuberculosis is concerning, given its status as the most common form of drug-resistant tuberculosis and a gateway to multidrug-resistant diseases. Molecular drug-susceptibility testing has improved access to timely diagnosis…
Rosalind S. Abernathy
Tuberculosis was the major cause of death in Europe and North America in the 18th and 19th centuries. This chapter deals with pulmonary tuberculosis in children — its pathogenesis, clinical manifestations, diagnosis, management, and prognosis. The tuberculin test is the basic dia…
Zhicong Xiang, Liuyu, Hequn Zou
…biological agents, potentially elevating the risk of latent tuberculosis infection (LTBI) reactivation and Mycobacterium Tuberculosis (MTB) dissemination. Tumor necrosis factor-α(TNF-α)is crucial in immune responses, and TNF-targeted therapies could raise the risk of …
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
The pathogenic potential of Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is attributable primarily to its complex and highly specialized repertoire of molecular determinants, comprising both proteins and lipids. These virulence factors operate synergis…
P Ponmani, Ratnesh Sinha, Sayan Kumar Das
Tuberculosis (TB) is one of the major public health problems which has cursed humanity for centuries. 45 % of the global incidence of TB and 50% of global mortality due to TB is contributed by the World Health Organisation (WHO) South-East Asia (SEA) Region. India is the top cont…
Sonali Paul, Nivedita Chatterjee, Asmeeta Sircar, Shimantika Maikap, Abhilasha Singh, et al.
Tuberculosis (TB) is primarily an airborne disease caused by the bacteria Mycobacterium tuberculosis. In a country such as India, the spread of this disease is quite rapid, especially with increasing air pollution. There are drugs for treatment, but these chemicals always have si…
Nitinkumar Marotrao Waghmare, Bharti Jagdale, Rahul Bhagwat Mapari, Harshada Bhushan Magar, Rohini Pochii, et al.
Having both diabetes and tuberculosis (TB) at the same time is a big public health problem because they affect each other in two ways: they make people more likely to get the diseases and they make the diseases worse. Active tuberculosis is more likely to happen if you have diabe…
Emily A Kendall, David W Dowdy
Screening populations at high risk for tuberculosis might improve clinical outcomes and reduce transmission, but the value and cost-effectiveness of population-based screening depend on the uncertain health impact of early tuberculosis detection. In this Personal View, we propose…
Pushpa Choudhary, Uma Phalswal, Mamta
Many people identify tuberculosis as a complex disease that requires a wide range of restrictions, lifestyle changes, and behavioral changes. Well-managed tuberculosis necessitates specific self-care management behaviors to not only control the disease but also prevent drug resis…
Jianfei Zhang, Du Zhang, Kaixi Tan, Bin Jiang
…tra-gene sequencing confirmed the presence of Mycobacterium tuberculosis, leading to a definitive diagnosis of mycobacterial infection. **INTERVENTIONS:** The patient received a 2-month intensive anti-tuberculosis regimen consisting of rifampicin, isoniazid, ethambutol, and pyra…
Parul Gupta, Ravindra Kumar, Rituraj Niranjan
…lular processes related to the immune system. miRNAs during tuberculosis (TB) infection are considered regulatory factors for the host immune system.has a great ability to survive and multiply in phagocytic cells, which makes it difficult to treat. It can replicate through variou…
Rafael Laniado-Laborín
One-third of the world's population is infected with M. tuberculosis. It is from this vast pool of infected people where the new cases of active disease originate. Most of these cases of latent infection are found in low-income countries where national tuberculosis programs conce…
Anil Kumar Gupta, Divakar Sharma, Amit Singh
Tuberculosis (TB) is a universally prevalent disease caused by an aerobic, gram-positive bacterium Mycobacterium tuberculosis (M. tuberculosis). It has continued to pose a significant threat to human health. The emergence of multi-drug resistance (MDR) strains of Mycobacterium tu…
Anjali Saxena, Summer Bhagra, Shuvayoo Das, Naveen Kaushik, Biswajit Saha
…drug-resistant and extensively drug-resistant strains of M. tuberculosis. The escalating prevalence of multidrug-resistant and extensively drug-resistant strains, compounded by the pathogen's extraordinary capacity to survive within host macrophages and pharmacologically impenetr…
Huilin Fang, Yan Xiong, Beibei Fu, Haibo Wu
Tuberculosis (TB) is an airborne infectious disease caused by the Mycobacterium tuberculosis (Mtb) complex organism. Alveolar macrophages (AMs) play key roles in immune defense, antigen presentation, immune regulation, and immune secretion during Mtb infection. Notably, AMs exhib…
Awalagaway Dhulappa, Shuang Wang, Manik Prabhu Narsing Rao
The symptoms of tuberculosis vary depending on where the bacteria are developing in the body. In the case of pulmonary tuberculosis, symptoms may include a persistent cough, chest discomfort, hemoptysis, weakness or weariness, weight loss, fever, and night sweats. The risk of tub…
Aan Sutandi, Martika Hijriani, Apriana Rahmawati, Harizza Pertiwi
Multidrug-resistant tuberculosis (MDR-TB) is defined as tuberculosis caused by Mycobacterium tuberculosis strains resistant to at least isoniazid (INH) and rifampicin (RMP), confirmed through drug sensitivity testing or rapid molecular diagnostics (e.g., GeneXpert).Due to this re…
F L Adão-Araújo, B G Ferreira, R Pontarolo, F S Tonin, S M Raboni
…ed as promising alternatives for the diagnosis of pulmonary tuberculosis, especially in settings where sputum collection is challenging and laboratory infrastructure is limited. We aimed to map the evidence on advanced technologies available for detecting pulmonary tuberculosis u…
Gangaram Bhadarge, Nandkishor Bankar, Sudhir Singh
… a major public health problem in all developing countries. Tuberculosis, an infectious disease caused by the bacteria Mycobacterium tuberculosis (MTB), is also a major cause of death in humans around the world. According to a World Health Organization (WHO) survey, MTB infects o…