Showing 126–148 of 148 documents
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Rinat Islamov, Bahkytzhan Kerimzhanova, Alexander Ilin
…ith a broad class of antibiotics. The experimental model of tuberculosis in guinea pigs caused by clinical multidrug-resistant strains of Mycobacterium tuberculosis shows antituberculosis, immunomodulatory, and anti-inflammatory activity. FS-1 is characterized by low acute toxici…
Siti Soidah, Toto Subroto, Irvan Faizal, Muhammad Yusuf
Rifampicin-resistant tuberculosis (RR-TB) remains a major threat to global TB control, primarily driven by mutations in thegene of(Mtb). Most resistance-conferring mutations occur within the 81-base pair RIF resistance determining region (RRDR), particularly at codons S450L, H445…
Bhaskar Chakraborty, Sampa Mitra
Multidrug-resistant tuberculosis (MDR TB) is a major challenge to any TB control programme. The objective of this work is to study the socio-demographic and the clinical profiles, along with some management indicators, of 23 MDR TB patients at the Domjur Block, India, in 2018. Th…
Andrea Monserrat Negrete-Paz, Gerardo Vázquez-Marrufo, Ma Soledad Vázquez-Garcidueñas
…g-resistant strains posing significant challenges to global tuberculosis control. Traditional single-genome analyses, while essential for identifying strain-specific mutations, are limited in capturing the full spectrum of genetic diversity related to virulence, drug susceptibili…
Marcos Abdo Arbex
Tuberculosis (TB) remains a critical global public health challenge, requiring therapeutic strategies that ensure high cure rates while minimizing bacillary transmission. The 2022 World Health Organization (WHO) update for drug-resistant TB treatment prioritized a novel, 6-month,…
Ravindra Kumar Garg
…vity of cerebrospinal fluid (CSF) tests. Standard pulmonary tuberculosis regimens are suboptimal for central nervous system involvement due to poor drug penetration and prolonged treatment. Emerging resistance, particularly to rifampicin and isoniazid, further complicates the man…
Jinyan Li, Haibo Feng, Dechun Chen, Huanrong Zhang, Yi Liao
…acteria pose significant global health burdens, withcausing tuberculosis-a leading infectious killer claiming over 1.25 million lives annually-and NTM driving pulmonary and ulcerative infections, particularly in immunocompromised populations. Autophagy, a conserved cellular degra…
Saad Alghamdi, Mohammad Asif
…pathogens, recent attention has focused on the treatment of tuberculosis. Therefore, recent developments have been directed towards examining currently used and newly developed antimycobacterial drugs and their toxicities and mechanism of action.
Sabryna Junker, Tim Clausen
…g potent activity against multidrug-resistant Mycobacterium tuberculosis. While challenges remain in cell entry, substrate selectivity, and pharmacokinetic optimization, BacPROTACs offer a promising route to develop next-generation antibiotics.
Maple Goh, Daniel Eisenkraft Klein, Aaron S Kesselheim
…bacillary leprosy and an emerging option for drug-resistant tuberculosis and non-tuberculous mycobacterial infections. Yet in high-income countries like the USA, access remains restricted through expanded access pathways and other limitations, despite decades of safe use. This re…
Caterina Davoli, Chiara Rossi, Andrea Ciccarone, Francesca Bertoni, Marina Calamelli, et al.
…nt for multidrug-resistant or rifampicin-resistant (MDR/RR) tuberculosis (TB) was traditionally long and poorly tolerated. In 2022, the World Health Organization recommended the first 6-month regimen (BPaLM), followed in 2025 by a second short-course option (BDLLfxC) with potenti…
Tushar Garg
Abstract Multidrug-resistant tuberculosis (TB) is a major issue in global health, prompting concerns from multilateral agencies and donor organizations about the ability of low- and middle-income countries (LMICs) to effectively treat patients with this disease as a result of poo…
Christopher Dye
…t there are ways to remedy the neglect, here illustrated by tuberculosis. Because curative treatment is currently the best form of prevention, the immediate priority for TB control is early diagnosis and chemotherapy, aided by developing novel diagnostics (easier) and therapeutic…
S. Jonathan Chapman, Grace V. Robinson, Rahul Shrimanker, Chris D. Turnbull, John Wrightson
Includes: Tuberculosis: epidemiology and pathophysiology, first-line anti-TB drugs, TB chemotherapy with comorbid disease, multidrug-resistant TB (MDR-TB), latent TB infection, TB and anti-TNF-α treatment, disseminated BCG infection (BCGosis), future developments in TB, non-tube…
Christopher Dye
Abstract Familiar endemic diseases such as tuberculosis (TB) are rarely seen as health emergencies, even though they kill millions of people each year. This chapter describes a variety of ways to remedy the neglect, illustrated by TB, including: highlight new dangers from old haz…
Lou W Kim, Victor Castillo, Alejandro Barbieri
…on of microbes. Specific pathogens, including Mycobacterium tuberculosis and Salmonella, subvert PI3K/PKB to evade immune responses, highlighting the pathway's dual role in host defense and pathogen survival. Targeting PI3K/PKB signaling or its inhibitory regulators may enhance p…
Anna Vassall
…e review of studies into the cost and cost-effectiveness of Tuberculosis (TB) control prior to researching this thesis. Although the broad strategy for TB control, Directly Observed Treatment Strategy (DOTS), is well established, it identifies areas for further research. These in…
Pedro Povoa, Luís Coelho, Jordi Carratala, Kelly Cawcutt, Sara E Cosgrove, et al.
…hogens (such as multidrug-resistant bacteria, Mycobacterium tuberculosis, or fungal infections) may be responsible, requiring alternative antimicrobial strategies. A septic complication related to pneumonia (e.g., empyema) or not (e.g., acalculous cholecystitis) may need to be ex…
Seungwha Paik, Soohyun Um, In Soo Kim, Eun-Jin Park, Kyung Tae Kim, et al.
…17: syntaxin 17; Tat: trans-activator of transcription; TB: tuberculosis; TBK1: TANK binding kinase 1; TFEB: transcription factor EB; TLR: toll like receptor; TNA: tanshinone IIA; TNF: tumor necrosis factor; UA: ursolic acid; ULK1/Atg1: unc-51 like autophagy activating kinase 1; …
Cesar Augusto Roque-Borda, Qi Zhang, Thi Phuong Truc Nguyen, Thi Thu Hoai Nguyen, Himadri Medhi, et al.
… faecium, Salmonella spp., Shigella spp., and Mycobacterium tuberculosis. Supported by extensive in vitro and in vivo data, this review catalogs dozens of successful AMP-antibiotic pairings, highlighting their fractional inhibitory concentration indices, clinical relevance, and i…
Jasdeep Singh, Prashant Pradhan, Arti Kataria, Sanjeev Sinha, Nasreen Z Ehtesham, et al.
We observed a high proportion of proteins in pathogenicspecies that can potentially undergo liquid-liquid phase separation (LLPS) mediated biomolecular condensate formation, compared to nonpathogenic species. These proteins mainly include the PE-PPE and PE-PGRS families of protei…
Huimin Chen, Ye Gu, Lei Song, Lihui Si
The global rise of multidrug-resistant (MDR) bacterial infections has exacerbated the need for effective vaccines to prevent these hard-to-treat pathogens. Traditional vaccine approaches have achieved tremendous successes but often fall short for pathogens like(TB), which evades …
Akihiro Ohkado, Seiya Kato
Epidemiology of TB provides important information for clinical diagnosis. The risk of TB infection and disease development depends on exposure to bacilli, i.e., contact with infectious TB patients, host factors such as comorbidities, and socio-economic conditions. TB was called a…