Showing 126–150 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Katherine Timboe, J Brooks Jackson, Greta L Becker
…hough effective treatments are available, treatment length, drug toxicity, and the emergence of drug-resistant strains have challenged TB control efforts. Current clinical trials are focused on developing shorter, safer, and more effective regimens that incorporate both new and r…
Mohd Shariq, Javaid Ahmad Sheikh, Farhan Ahmed, Anwar Alam, Seyed E. Hasnain, et al.
…men, which is lengthy and complex, coupled with the rise of drug-resistant strains, highlights the urgent need for new therapeutic solutions. In response, drug repurposing has gained attention as a promising strategy against M. tb. This method involves finding new uses for existi…
Mangal S. Kadam, Burra V L S Prasad
…lobal health burden because of increased rate of antibiotic resistance, an alert raised by WHO. RsmD is involved in the proper functioning of protein translation and protecting the organism (parasite) from drug action through methylation which is one of the most common epigenetic…
Zonghai Chen
…in the world. In recent years, the rising incidence rate of drug-resistant TB has posed a challenge to traditional anti-TB drugs; drug-resistant TB is difficult to treat and seriously threatens public health, so it is urgent to develop new anti-TB drugs. Only 5–10% of infected pe…
Delfly Booby Abdjul, Fitri Budiyanto, Joko Tri Wibowo, Tutik Murniasih, Siti Irma Rahmawati, et al.
…onged treatment durations, and the increasing prevalence of resistance to commercial TB drugs. The emergence of resistance to anti-TB drugs has necessitated urgent research into drug discovery and development, focusing on novel mechanisms of action against Mycobacterium tuberculo…
Sarman Singh, Arti Shrivas
…ain undetected and unreported. On top of that, emergence of drug-resistant TB poses a major challenge. Therefore, a Reliable, Accessible, Cost-Effective, and Easy (RACE) diagnostic modality is crucial for starting suitable treatment of TB and curtailing its transmission. In the l…
Prakruthi Shivakumar, Kavitha Sunil Shettigar
…osis, and a public health concern due to increased cases of drug-resistance and high mortality rates. Rapid identification of tuberculosis is necessary for its early treatment and to prevent the emergence of drug-resistant strains. For effective management of patients, rapid, cos…
Radha Gopalaswamy, Selvakumar Subbian
SUMMARYThe global resurgence of drug-resistant tuberculosis (DR-TB) presents a formidable challenge to public health, driven by a complex interplay of mycobacterial evolution, dynamics and outcomes of host-pathogen interactions and systemic gaps in diagnosis and treatment strateg…
Priya Shrivastava, Laxmikant Gautam, Anamika Jain, Nikhar Vishwakarma, Sonal Vyas, et al.
…e misuse of antimicrobials and subsequent rise of the multi-drug resistant (MDR) opportunistic intracellular pathogens have led to a paradigm shift in the established perspective of antimicrobials and bacterial-human relations. Antibiotic resistant strains of mycobacterium tuberc…
Siddhant Shetty, Priti Kambli, Camilla Rodrigues
…n and close clustering. Added to this is the new problem of drug resistance, its early diagnosis and targeted therapy. The current diagnostic capabilities have their own limitations, be it genotypic or phenotypic tests. They have a high turnaround time, do not detect drug resista…
Lan Zhao, Yao Zhang, Rui Liu, Beibei Ni, Lijun Bi
… develop active TB. Despite the success of existing anti-TB drugs in controlling transmission, significant challenges remain, including long treatment durations, severe side effects, suboptimal treatment adherence, and inevitable drug resistance. Even newly developed drugs may fa…
Feng Chen, Yifan Shen, Qianhui Yan, Daishan Zheng, Xiaoli Chen, et al.
…dings from the past decade, along with reported results fromdrug susceptibility assays and molecular diagnostics, to explore key pathogenic genes in BCG strains. We compare differences in pathogen characteristics, host immune responses, and clinical manifestations between BCG dis…
Saad Alghamdi, Mohammad Asif
…herapy, the extensive use and misuse of these antimicrobial drugs have caused the emergence of microbial resistance, which is a serious risk to public health. In particular, the emergence of multidrug-resistant pathogens has become a serious difficulty in the therapy of pathogeni…
A J Hickey, P G Durham, A Dharmadhikari, E A Nardell
Since the 1990s the rising incidence of multiple drug resistant TB, particularly in the context of human immunodeficiency virus co-infected patients, has threatened global TB control. At that time funding agencies began to support formal investigation of aerosol therapy which unt…
J Boffa, D Vambe, C Khosa, B José, N Ndjeka, et al.
…eration sequencing, targeted universal testing, and shorter drug-resistant and paediatric TB regimens. We also identify the key challenges, such as inconsistent drug access, increasing drug resistance and limited healthcare capacity, which continue to affect progress. Health syst…
Deepshikha Singh, Vikram Singh, Afrasim Moin, Manu Gangadhar, Bistuvalli Chandrashekarappa Revanasiddappa, et al.
…al, anti-malarial, anti-inflammatory, and enzyme-inhibiting drugs. To cure TB, scientists were driven to establish novel pyrimidine derivatives. The main objective of the current review is to identify and develop new pyrimidine moiety- containing derivatives that have been assess…
Stefano Orlando, Loredana Andreea Silaghi, Mariagrazia Cicala, Mathambo William Lowole, Cacilda Massango, et al.
… barriers faced by key populations. Emerging issues such as drug resistance and declining political commitment risk reversing progress. Investments in HIV have yielded broader benefits for health systems, supporting integration with services for tuberculosis and noncommunicable d…
Na Tian, Hongqian Chu, Qi Li, Hong Sun, Jingfang Zhang, et al.
Current TB treatment regimens are hindered by drug resistance, numerous adverse effects, and long treatment durations, highlighting the need for 'me-better' treatment regimens. Host-directed therapy (HDT) has gained recognition as a promising approach in TB treatment. It allows t…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…rculosis (TB) diagnosis, treatment, and control amid rising drug resistance and global health challenges. Recent studies focus on elucidating protein structures and interactions critical to bacterial survival, virulence, and drug resistance, enabling the identification of novel t…
Gerald Mboowa
Drug-resistantremains a significant global public health threat. While whole-genome sequencing (WGS) holds immense promise for understanding transmission dynamics and drug resistance mechanisms, its integration into routine surveillance remains limited. Additionally, insights fro…
Xinen Kong, Jiayi Yang, Jiajun Wang, Jiaxiang Li, Xiaoying Jin, et al.
…c health burden worldwide. The increasing threatens of multidrug-resistant/extensively drug-resistant TB, human immunodeficiency virus (HIV) co-infection, lack of effective vaccines and diagnosis methods, as well as the low treatment efficacy of anti-TB therapeutics lead to multi…
Gail B Cross
…ss their potential to transform clinical management of both drug-susceptible and drug-resistant disease. **RECENT FINDINGS:** Evidence from landmark trials, including Nix-TB, ZeNix, TB-PRACTECAL, STREAM, Study 31/A5349, SHINE, TRUNCATE-TB, endTB and BEAT-TB has supported the use…
Ren Fang, Xingyue Yang, Xiaotian Li, Jiayin Xing, Mingrui Sun, et al.
…tensive use of antibiotics has led to the emergence of multidrug-resistant and extensively drug-resistant MTB strains, intensifying the challenges associated with TB treatment. In this context, host-directed immunotherapy has emerged as a promising adjunct strategy that aims to m…
Balaji Muralikrishnan, Vipin Mohan Dan
…er the heart disease. In both cases, be it the emergence of drug-resistant strains of Mycobacterium tuberculosis or the drug-resistant cancerous cells, they pose a serious health threat that needs to be addressed urgently. Plethora of novel bioactive molecules that deal with the …
Trupti B. Naik, Vijaykumar Mane, Amruthkishan K. Upadhya
…r long periods, which is a key factor in the development of drug resistance and has become a major treatment roadblock. Objectives: To determine the species of Enterococci isolated from different clinical samples. 2. To determine the antimicrobial susceptibility pattern of Entero…