Showing 76–100 of 200 documents
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Rosella Centis, Lia D'Ambrosio, Giovanni Battista Migliori
…ituberculosis therapy is crucial to maintain adequate blood drug level. The emergence and spread of drug-resistantstrains is mainly favored by the inadequate medical management of patients. The therapeutic approach for drug-resistant tuberculosis is cumbersome, because of the poo…
William R McManus, Katie Mulvey, Jeffrey S Schorey
…important aspect of their pathogenesis and known antibiotic resistance. In this review, we discuss the pathogenesis of this important mycobacterial species, what we know of its ability to form biofilmsandand gaps in our knowledge of these processes. We also discuss how we may lev…
Emranul Kabir, Mahbub Alam, Md Ismail Haque
… and combination therapies, but challenges like toxicities, drug resistance, HIV incompatibility, and lack of knowledge about drug processes persist. TB remains one of the most prevalent infectious diseases globally, impacting millions annually. It has led to the spread of multid…
H Manisha Yapa, Emily L-H MacLean, Nicolas A Menzies, Peter J Dodd, Anna Dean, et al.
SUMMARYDrug-resistant tuberculosis (DR-TB) causes substantial morbidity and mortality and has hindered progress toward TB elimination. This slowed progress toward the WHO End TB Strategy's targets was exacerbated by lower TB detection during the COVID-19 pandemic. To inform resea…
M Amiri, M Cheraghi, M J Nasiri, D R Silva, G Sotgiu, et al.
…efficacy of the regimens to treat rifampicin-resistant/multidrug-resistant TB (RR/MDR-TB), underscoring the persistent need for efficacious shorter treatments. The aim of this scoping review was to explore safety, quality of life (QoL), and unmet needs associated with RR/MDR-TB i…
G. Mac-Fiberesima, SD Abbey, C. K. Wachukwu, O. Azuonwu
Tuberculosis is a life-threatening infectious disease that is responsible for the death of most people all over the world. It is characterized by coughing, fever, night sweats and loss of weight due to the pathology of Mycobacterium tuberculosis that causes the disease. In some c…
Andrew Woodhouse
Multi-drug resistant tuberculosis (MDR-TB) is defined by resistance to both isoniazid and rifampicin, the two most effective first line anti-tuberculous drugs. Resistance to one or other drug plus resistance to other first line agents (streptomycin, pyrazinamide and ethambutol) r…
Meenakshi Jain, Himanshu Sharma, Menka, Tushar Dash, Rehan Hamdulay, et al.
…s annually. Despite progress in treatment, the emergence of drug-resistant strains, including multidrugresistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), poses challenges to effective management, thus necessitating the development of novel medications. Nitroimidazo…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…ansmission and worsen outcomes. The emergence and spread of drug-resistant TB, including multidrug-resistant (MDR-TB), extensively drug-resistant (XDR-TB), and totally drug-resistant (TDR-TB) strains, pose significant challenges to effective treatment and control, contributing to…
Ahmed Al Hammadi, Fatima Ali Salem Khalfan Al Dhaheri, Huda Sulaiman Al Dhanhani, Jens Thomsen
… tuberculosis and malaria. On the other hand, antimicrobial resistance (AMR) has emerged in the UAE, mirroring global trends as a result of the misuse of antimicrobials. As of 2020, an average of 35% of common pathogens in the UAE have been shown to be multi-drug resistant (MDR),…
Karuna Gokarn, Ramprasad B. Pal
Background: The problem of drug-resistant Mycobacterium tuberculosis (M.tb) is alarming and therefore there is an immediate need for alternative or complementary drugs. This could be achieved by repurposing existing FDA-approved drugs. In this study, the anti-tuberculosis activit…
Violeta Mangalagiu, Ramona Danac, Anda-Mihaela Olaru, Dumitrela Diaconu, Ionel I. Mangalagiu
…threat threatening against human life and, the phenomena of drug resistance, multidrug-resistant and total drug-resistant to TB complicated the situation even worse. Within this work, a series of thirteen compounds having a monoindolizine mono-salt skeleton was designed and synth…
Stuti Ghosh, Sudipto Saha
Antimicrobial resistance (AMR) is a serious threat to global public health. The multidrug and extensively drug-resistant Mycobacterium tuberculosis (MTB) and drug-resistant ESKAPE are important health-associated infections. In this chapter, applications of artificial intelligence…
Sadia Asif, Ashik Francis, Emmanuel Ijabani, Anil Thakur
…ise of new fungal pathogens and the alarming spread of multidrug resistance in species such as Candida auris, Candida glabrata, Aspergillus fumigatus, and Cryptococcus neoformans. Resistance to antifungal drugs is complex, arising from natural resistance traits, genetic mutations…
Amit Sharma, Poulomi Chatterjee, Shashank Shastry
MDR TB treatment is now facing the perils of emerging resistance to BDQ(bedaquiline) and DLM(delaminid). Both DLM and PRT(pretomanid) belong to the nitroimidazole group of drugs. Drug resistance in Mycobacterium Tuberculosis (MTB) is an ever changing, continuous and evolving proc…
Seyed Mehdi Hosseini, Narjes Morovati Moez, Mohammad Reza Arabestani
…ruse and abuse of prescription antifungal and antibacterial drugs, which causes organisms to gradually acquire the ability to overcome the drug and develop resistance. Moreover, many antimicrobials display a variety of toxicities for human use. Also, multiple resistance of bacter…
S.Z.Z. Cobongela, Tintswalo Mgwenya
…iddle-income countries, are exacerbated by the emergence of drug-resistant (DR) strains. The limitations of conventional treatments, which rely on older drugs developed over 40 years ago, highlight the need for advanced treatment strategies. Recent advancements include the develo…
Anjali Saxena, Summer Bhagra, Shuvayoo Das, Naveen Kaushik, Biswajit Saha
…es, poor patient compliance, and toxicities associated with drug treatment, as well as concerns arising from increasingly prevalent multidrug-resistant and extensively drug-resistant strains of M. tuberculosis. The escalating prevalence of multidrug-resistant and extensively drug…
Gordon Wells, Chaima Hkimi, Lyndon Zass, Judit Kumuthini
…arly pertinent in the era of the escalating threat posed by drug-resistant TB within the African population. This approach involves tailoring treatment regimens based on various factors, including drug susceptibility, comorbidities such as HIV, and host genetics. Precision medici…
Alina Malic, Adriana Niguleanu, Tatyana Osipov
…us therapeutic regimens with a combination of at least four drugs. Adherence to the treatment regimen is crucial for efficacy outcomes based on the achievement of appropriate drug levels. Drug-resistant () strains are mainly favored by inadequate TB management. Inappropriate trea…
Nicole C. Cardoso, Carel B. Oosthuizen, Nashied Peton, Vinayak Singh
…obal health concern given the increase in multiple forms of drug-resistant TB. This underscores the importance of a continuous pipeline of new anti-TB agents. From recent studies, it is evident that the increase in drug efficacy is being achieved through re-engineering old TB-dru…
Nirjhar Saha, Mainak Chatterjee, Tejas M. Dhameliya, Asit K. Chakraborti
…reatment of TB becomes problematic due to the appearance of drugresistant (DR), multidrug-resistant (MDR), extremely drug-resistant (XDR), and totally drug-resistant (TDR) TB strains, as well as co-infection with HIV. For nearly half a century since the first TB drug was invented…
Manal Arshad Malik, Aleena Kamran, Dua Ahsan, Aafia Amjad, Sara Moatter, et al.
…outcomes, especially in children, due to delayed diagnosis, drug resistance, and limited diagnostic techniques. **METHODS:** This review provides a comprehensive overview of recent advancements in TBM management and treatment. A systematic search was performed across major datab…
Evelina Lesnic, Alina Malic
The culture with the drug susceptibility testing are the gold standard in diagnosis of tuberculosis (TB). However the use of the new molecular genetic test for identification of Mycobacterial tuberculosis DNA based on polymerase chain reaction contributed to earlier diagnosis of …
Ayushi Sharma, Gyanendra Singh, Rahul Shrivastava
…per the therapeutic progress. Increasing incidences of multidrug-resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis strains further complicate tuberculosis control. Modern research, therefore, focuses on development of new antitubercular drugs to trea…