Showing 51–73 of 73 documents
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Remmy Shawa, Fons Coomans, Helen Cox, Leslie London
…ess to effective diagnosis and treatment for drug-resistant tuberculosis (DR-TB) remains a persistent ethical, human rights and public health challenge globally. In addressing this challenge, arguments based on a Human Rights-Based Approach (HRBA) to health have most often been f…
Ted Lankester
…chapter describes the recent status, impact, and control of tuberculosis (TB) worldwide through the End TB strategy. It gives examples of how government and civil society programmes can work together, with the roles and tasks of each clearly defined. It gives examples of the many…
Manya Jain, Rajan Vyas
The global escalation in tuberculosis (TB) cases accompanied by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of(emphasizes the critical requirement for novel potent drugs. Thedemonstrates extraordinary adaptability, thriving in diverse c…
Nnamdi Ikemefuna Okafor, Precious Nnaji, Ngozi Francisca Nnolum-Orji, Yahya E Choonara
Tuberculosis (TB) is considered a major infectious disease by the World Health Organization. The WHO estimates that there are 1.8 million TB deaths, and 10.4 million new cases of the disease reported yearly. While there are conventional therapies for TB, they have drawbacks such …
Patrick Howlett, Robert J. Wilkinson, Ben J. Marais
…ds, Disease and pathogenesis, Clinical features, Diagnosis, Tuberculosis treatment, TB and HIV, TB in Children, Treatment regimens, Multi-drug resistant and extensively drug resistant TB , Lessons learned in TB treatment and control
Sonia Menon, Kobto Ghislain Koura
…ing disease diagnosis and management. Despite advancements, tuberculosis (TB) remains a public health challenge, particularly in low- and middle-income countries where diagnostic methods are limited. In this scoping review, we aim to examine the potential role of AI in TB control…
Ayman Elbehiry, Eman Marzouk, Adil Abalkhail
Tuberculosis (TB) remains a leading infectious killer, increasingly complicated by multidrug-resistant (MDR) and extensively drug-resistant (XDR) disease; current regimens, although effective, are prolonged, toxic, and often fail to reach intracellular bacilli in heterogeneous lu…
Ariel Torres, Gisselle Trujillo, José Daniel Sánchez
Drug-resistant tuberculosis (DR-TB) represents a major public health threat, particularly in the prisons of Latin America and the Caribbean, where rates are up to 40 times higher than those observed in the general population. These facilities act as community amplifiers due to ov…
Kenneth W Foreman, Hui-Chen Foreman
Tuberculosis (TB), primarily caused by(Mtb), remains a leading cause of infectious disease mortality worldwide. Global TB control efforts face several hurdles, including the lack of a broadly effective vaccine, limited sensitivity of current diagnostics, particularly for paucibac…
Federico Appetecchia, Mariangela Biava, Giovanna Poce
Tuberculosis is a leading cause of mortality and morbidity worldwide, claiming 1.2 million deaths (including 208 000 people with HIV) and 10 million new cases in 2019. Current treatment suffers from significant shortcomings such as length, dosage regimen, toxicity, and resistance…
Meenakshi Jain, Himanshu Sharma, Menka, Tushar Dash, Rehan Hamdulay, et al.
Tuberculosis (TB) stemming from Mycobacterium tuberculosis (Mtb) continues to pose a formidable global health challenge, claiming numerous lives annually. Despite progress in treatment, the emergence of drug-resistant strains, including multidrugresistant TB (MDR-TB) and extensiv…
Emranul Kabir, Mahbub Alam, Md Ismail Haque
Tuberculosis (TB) treatments rely on novel compounds, improved delivery, and combination therapies, but challenges like toxicities, drug resistance, HIV incompatibility, and lack of knowledge about drug processes persist. TB remains one of the most prevalent infectious diseases g…
Wiktoria Drzał, Nazar Trotsko
Tuberculosis (TB) remains one of the leading causes of mortality worldwide, exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains. In the pursuit of novel therapeutic strategies, thiazolidin-4-one derivat…
Gyanshankar Mishra
Multidrug-resistant tuberculosis (MDR-TB) is tuberculosis that is resistant to at least rifampicin and isoniazid, which threatens to erode the current progress in the global control of TB. Drug resistance may further worsen with the appearance of drug resistance to at least one o…
Andrew Woodhouse
Multi-drug resistant tuberculosis (MDR-TB) is defined by resistance to both isoniazid and rifampicin, the two most effective first line anti-tuberculous drugs. Resistance to one or other drug plus resistance to other first line agents (streptomycin, pyrazinamide and ethambutol) r…
Stuti Ghosh, Sudipto Saha
… The multidrug and extensively drug-resistant Mycobacterium tuberculosis (MTB) and drug-resistant ESKAPE are important health-associated infections. In this chapter, applications of artificial intelligence (AI) on several fronts to tackle AMR are discussed, including AI-assisted …
Biniam Paulos, Daniel Bisrat, Maramawit Yonathan Yeshak, Kaleab Asres
Tuberculosis (TB), an infection caused by, affects nearly one-third of the world's population. It is estimated that TB infects around ten million people worldwide, with no less than two million fatalities annually. It is one of the treatable infections due to improved diagnostic …
Baji Baba Shaik, Kimeshni Moodley, Safiyah Ghumran, Muhammad D Bala, Parvesh Singh, et al.
…the biological function, target inhibition and diagnosis of tuberculosis (TB) diagnosis has considerably advanced. The application of target-based drug discovery techniques have become a more powerful tool for medicinal chemists in developing new therapeutic strategies, such as i…
Ronald Labonté, Arne Rückert
…extensively drug-resistant older infectious illnesses (e.g. tuberculosis, malaria), while the spread of other endemic infections is accelerated by climate change. Antimicrobial resistance has risen near the top of global health threats, posing health security risks within and bet…
Ahmed Al Hammadi, Fatima Ali Salem Khalfan Al Dhaheri, Huda Sulaiman Al Dhanhani, Jens Thomsen
…s a low-burden and low-risk country for global threats like tuberculosis and malaria. On the other hand, antimicrobial resistance (AMR) has emerged in the UAE, mirroring global trends as a result of the misuse of antimicrobials. As of 2020, an average of 35% of common pathogens i…
Jessica Ceramella, Annaluisa Mariconda, Domenico Iacopetta, Maria Marra, Alessia Catalano, et al.
…portance of 2-oxazolidinones is related to the treatment of tuberculosis (TB), primarily MDR-TB and extensively drug-resistant XDR-TB. Linezolid, the first oxazolidinone antibiotic approved by FDA, is still used in therapy despite common adverse events, such as myelosuppression a…
Luis M Rodríguez-Martínez, Jose L Chavelas-Reyes, Carlo F Medina-Ramírez, Eli Fuentes-Chávez, Zurisaday S Muñoz-Troncoso, et al.
Tuberculosis (TB), caused by, continues to be a leading cause of morbidity and mortality in Mexico, with more than 20,000 new cases annually and a rising proportion of drug-resistant strains. This work addresses the molecular epidemiology of TB in the Mexican context, emphasizing…
Omid Nikjeh, Seyedehparmis Rejali, Kayvan Sasaninia, Vishwanath Venketaraman
For drug-susceptible TB, the WHO-endorsed first-line regimen (isoniazid, rifampicin, ethambutol, pyrazinamide) remains the global reference. Therapy must always be tailored to drug susceptibility, especially in MDR- and XDR-TB. HIV-associated mycobacterial infections-including(TB…