Showing 51–75 of 82 documents
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Katherine Timboe, J Brooks Jackson, Greta L Becker
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is the leading infectious cause of death globally. Although effective treatments are available, treatment length, drug toxicity, and the emergence of drug-resistant strains have challenged TB control efforts. Current clinic…
Yang Cui, Haoran Li, Tianhui Liu, Rujie Zhong, Jiaying Guo, et al.
Tuberculosis (TB) remains a formidable global public health challenge. The rising prevalence of drug-resistant TB and increased human immunodeficiency virus(HIV) co-infection further exacerbate TB control efforts. Mycobacterium tuberculosis (Mtb) achieves highly heterogeneous inf…
Buyun Xu, Mengjuan Yuan, Lisa Yang, Lan Huang, Jingxin Li, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is one of the leading infectious causes of adult mortality worldwide. The Bacillus Calmette-Guérin (BCG) vaccine is currently the only approved vaccine for TB prevention, but its protective efficacy against adult…
Kate Louther
…c Health Nurses perform many of the fundamental services of tuberculosis control practices, and they ensure patients receive proper treatment, monitor their health, and work to prevent the spread of the disease through community outreach and screening. The cost of managing tuberc…
Wiwat Chancharoenthana, Tanaya Siripoon, Supitcha Kamolratanakul, Viravarn Luvira, Weerapong Phumratanaprapin, et al.
SUMMARYLatent tuberculosis infection (LTBI) is common and preventable among patients with chronic kidney disease (CKD), where uremia and iatrogenic immunosuppression heighten reactivation risk. This narrative review synthesizes evidence across pre-dialysis CKD, dialysis, and kidn…
Ruizi Ni, Yanhua Liu, Alice Armanni, Giulia Ghisleni, Sara Fumagalli, et al.
SUMMARYOne quarter of the world's population carries latent tuberculosis infection (LTBI), an invisible reservoir that must be drained to end the global tuberculosis (TB) epidemic. This review charts the evolution of LTBI diagnosis from the tuberculin skin test (TST) and interfer…
Eduarda Rabello, Fernanda de-Paris
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, a burden further exacerbated by HIV co-infection and the increasing prevalence of drug-resistant strains. Although a wide range of laboratory diagnostic methods are currently av…
Akanksha Sirohi, Yash Vardhan Trivedi, Tavishi Katoch, Benjamin Walters, Vasu Bansal, et al.
ObjectivesTo address the challenges of tuberculosis (TB) control in the United States post-COVID-19, focusing on high-risk populations, current diagnostic and treatment strategies, and the importance of addressing clinical and social determinants of health to achieve TB eliminati…
Coad Thomas Dow, Liam Obaid
…omise as a host-directed therapy for both active and latent tuberculosis (TB). Unlike DHEA, BEA lacks hormonal side effects yet retains potent immunomodulatory activity. It promotes a Th1-skewed immune response by enhancing interferon-γ (IFN-γ) and tumor necrosis fact…
Paul H. Mason
This ethnography of cross-border tuberculosis (TB) healthcare seeking on Daru Island, Papua New Guinea, uncovers the complex interplay between individual experiences and broader social, economic, and political forces shaping TB prevalence and outcomes. Focusing on Aluni and her f…
Andrew Blauvelt, Bruce E Strober, Guy S Eakin, Leah McCormick Howard, Christy Langan, et al.
**BACKGROUND:** Although testing for latent tuberculosis (TB) infection has been standard practice for psoriasis patients being treated with interleukin (IL) 17 or IL-23 inhibitors, evidence for this practice is weak. **OBJECTIVES:** To review evidence on safety of IL-17 and IL-…
Charisse Mandimika, Gerald Friedland
…ment of TB/HIV disease. Drug-susceptible and drug-resistant tuberculosis (TB) and human immunodeficiency virus (HIV) epidemics are a consequence of reactivation of latent TB infection (LTBI), treatment-related amplification of TB resistance mutations, and transmission of both sus…
Abhilasha Tripathi, Surya Kant, Prem Prakash Kushwaha, Shashank Kumar
There are millions of cases of tuberculosis (TB) get undiagnosed annually. New tactics and innovative diagnostic tools to control TB are urgently needed throughout the world. Exact diagnosis and early treatment of TB and latent TB infection are dynamic to prevent and control the …
David S Gomes, Joana Lourenço, Maria J Moura, Mariana Vieira, João Pedro Ramos, et al.
**BACKGROUND:** The co-occurrence of tuberculosis (TB) and diabetes mellitus (DM) presents a growing public global health concern. Managing DM during anti-TB therapy is challenging due to potential drug-drug interactions, especially with rifamycin (RIF). **RESEARCH QUESTION:** A…
Seyedeh Mahnaz Karimi
Tuberculosis (TB) is a potentially serious infectious disease and one of the ten leading causes of death worldwide. Even today, available treatments are long and difficult, and TB control is complicated by problems such as inadequate global public health infrastructure, human imm…
Gerry Davies, Charles A. Peloquin
Treatment of active and latent tuberculosis has evolved steadily over the 70 years since the dawn of the antibiotic era with 25 drugs from many distinct classes now in common use in different clinical situations. Pyrazinamide is expected to cause clinically significant drug inter…
Joseph Sturman, Jyoti Baharani, Jed Ashman, Lorraine Harper, Adam F Cunningham, et al.
Tuberculosis (TB) and chronic kidney disease (CKD) represent an extant local and global syndemic, with TB incidence rates in the UK end-stage renal failure population far surpassing those of the general population in endemic countries. Patients with CKD generally have latent TB r…
Yi En Ding, Matthew Tze Jian Wong, Mohd Nor Norazmi, Venugopal Balakrishnan, Gee Jun Tye
Tuberculosis (TB) remains as a significant global health threat to date, with latent TB infection (LTBI) serving as a major reservoir for future active disease cases. A practical approach to an effective control and eradication of TB hence, requires an explicit identification of …
Dinara Adjablaeva
Latent tuberculosis infection is an asymptomatic condition in which patients carry the bacteria, but do not show any sign of illness, however they are at risk of disease activation at any time in the future. Understanding of influence of latent tuberculosis infection on the physi…
Shahnawaz Majeed, Safiya Mehraj, Zahoor Ahmad
Tuberculosis still stands as the world’s leading infectious disease as 1/4th of the world’s population harbors Latent TB infection (LTBI) > 10 million develops active TB and ~ 1.5 million people die per year. Approximately 4,65,000 people fell ill with multidrug or rifampicin-…
Lara Beth Gadkowski, Connie A. Haley
In patients with HIV infection, tuberculosis (TB) can present at any CD4 T-cell count, with a diversity of pulmonary and extrapulmonary manifestations. Because TB is spread via a respiratory route and may rapidly progress if untreated, providers should maintain a high level of su…
Ajit Lalvani, Clementine Fraser, Manish Pareek
…s population is estimated to be infected with Mycobacterium tuberculosis (M.tb) approximately 1.7 billion people. Cell-mediated immunity in the host response to M.tb is of central importance in the diagnosis of M.tb. All the commercially available platforms exploit the fact that …
Wenzhong Hu, Yun Xu
…liximab' as research hotspots. Cluster analysis showed that tuberculosis, latent tuberculosis infection and hepatitis B virus were the focus of attention. **CONCLUSIONS:** Research on opportunistic infections in RA has shown a clear trend of growth and extensive international co…
Siranjeevi Rangaraj, Anushka Agarwal, Sharmistha Banerjee
Tuberculosis (TB), caused by(), is the most common secondary infection in the Human Immunodeficiency Virus (HIV) infected population, accounting for more than one-fourth of deaths in people living with HIV (PLWH). Reciprocally, HIV infection increases the susceptibility to primar…
Nickolas Yedgarian, Jacqueline Agopian, Brandon Flaig, Fouad Hajjar, Arshavir Karapetyan, et al.
…fenidone, are effective but may increase the risk of latent tuberculosis reactivation in certain patients. Experimental therapies such as artemisinin derivatives have shown promise in preclinical TB fibrosis models, while cell-based therapies like bone marrow-derived mononuclear …