Showing 51–75 of 200 documents
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Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong
…B) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control. An increasingly recognized and complex challenge is heteroresistance, the coexistence of drug-susceptible and drug-resistantsubpopulation…
Jasdeep Singh, Prashant Pradhan, Arti Kataria, Sanjeev Sinha, Nasreen Z Ehtesham, et al.
… proteins. We also mapped identified LLPS proteins in(M.tb) drug-resistant databases PubMLST and TBProfiler, based upon the WHO 2023 catalogue of resistance-associated mutations. High sequence conservation of LLPS-associated proteins in various multiple drug-resistant M.tb isolat…
Jessica Renz, Kazeem A Dauda, Olav N L Aga, Ramon Diaz-Uriarte, Iren H Löhr, et al.
…t the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology and in applied approaches to address the global health challenge of antimicrobial resistance (AMR). In this minireview, we discuss…
Simon Tiberi, Temi Lampejo, Alimuddin Zumla
Rifampicin-resistant Tuberculosis (RR-TB) and Multidrug resistant Tuberculosis (MDR-TB) are a current global health threat, and are characterised by high mortality, chronic sequelae, complexity and high cost. The drug resistant form of this infectious disease was globally respons…
Ariel Torres, Gisselle Trujillo, José Daniel Sánchez
Drug-resistant tuberculosis (DR-TB) represents a major public health threat, particularly in the prisons of Latin America and the Caribbean, where rates are up to 40 times higher than those observed in the general population. These facilities act as community amplifiers due to ov…
Akhil Sharma, Vikas Sharma, Shivika Sharma, Sonu Sharma, Monu Sharma, et al.
…ions of conventional treatments and the rising incidence of drug-resistantstrains. This review consolidates the advancements in nanotechnology-based therapeutics, inhalable formulations, CRISPR-Cas tools, host-directed therapies (HDTs), and nanoparticle-based vaccine development …
Jambi Ratna Raja Kumar, Laxmi Bewoor, Kalyani Kadam, Sunil M Sangve, Mayuri B Satpute
…pes, complicated by the hierarchical clinical taxonomies of drug resistance that are not typically leveraged in existing predictive modeling. We developed a taxonomy-driven, hierarchical classification framework trained on a large and diverse multimodal cohort of subjects from th…
Leeberk Raja Inbaraj, Bella Devaleenal Daniel, Chandrasekaran Padmapriyadarsini
…s and management. The global and regional burden of TBM and drug resistant TBM (DRTBM) are largely unknown. DRTBM is associated with poorer treatment outcomes. The wider use of latest rapid diagnostic molecular tests including nucleic acid amplification tests paves way for better…
Gyanshankar Mishra
Multidrug-resistant tuberculosis (MDR-TB) is tuberculosis that is resistant to at least rifampicin and isoniazid, which threatens to erode the current progress in the global control of TB. Drug resistance may further worsen with the appearance of drug resistance to at least one o…
Koushik Mukherjee, Pritam Saha, Kirat Kumar Ganguly, Somjyoti Chakraborty, Swarnali Ghosh, et al.
…bal health challenge, particularly due to the appearance of resistance towards anti-tuberculosis drugs (ATD), mainly multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Mtb poses resistance towards the currently used first- and second-line regimen. Recent adva…
Arpit Raj, Vikrant Abbot, Kapil Kumar
The rational drug design and development of new medication requires an appropriate understanding of the pharmacokinetics and pharmacodynamics of anti-TB drugs. Nevertheless, the implementation and processing of drugs were not quite effective at the early stage of development that…
Ndiviwe Mphothulo, Marian Loveday, Hanlie Myburg
**BACKGROUND:** People on drug-resistant tuberculosis (DR-TB) treatment face multiple challenges, which include severe disease and treatment side effects, together with psychosocial and socioeconomic challenges. These challenges impact patients' ability to remain in care and comp…
Sungwon Jung
…es the gap between point-of-care rapid tests and phenotypic drug susceptibility testing (pDST) in drug-resistant tuberculosis (DR-TB). The 2025 World Health Organization (WHO) consolidated guidelines and the operational handbook place tNGS after initial automated nucleic acid amp…
Kolimi Prashanth Reddy, Gurdeep Bhatti, Nidhi Singh, Pallab Datta
…rotic indication, CFZ has evolved for the treatment of multidrug-resistant tuberculosis (MDR-TB), nontuberculous mycobacterial (NTM) diseases, small-cell lung cancer, and as an adjunct in therapies targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and cy…
Sandhya Krishnan Radhakrishnan, Varadharajan Sundaramurthy
…ellular persistence, granuloma formation, transmission, and drug resistance. These lipids modulate host-pathogen interactions by altering host membrane biophysics, hijacking phagosome maturation, and interfering with host immune pathways, including autophagy and inflammatory sign…
Nicole Rose Alberto, Isabelle Rose I Alberto, Ianne Keziah Agripo, Gabrielle P Flores, Madeleine Nicole G Bernardo, et al.
Drug-resistant tuberculosis (DR-TB) heavily contributes to the global challenge of antimicrobial resistance (AMR), resulting in increased morbidity among tuberculosis cases. The Association of Southeast Asian Nations is home to approximately 10% of the world's population, account…
Ignacio Monedero-Recuero, Xiaolin Wei, Fabienne Jouberton, Raquel Duarte, María Rodríguez-Ortega, et al.
…g the provision of quality tuberculosis (TB) care. Managing drug-resistant TB (DR-TB) in these settings is particularly challenging. War and post-war conditions could potentially amplify resistance. However, evidence on DR-TB in CE-affected countries remains scarce. **METHODS:**…
Pauline Howell, Jonathan Stillo, Anja Reuter, Tendai Nkomo, Carole D Mitnick, et al.
Drug-resistant tuberculosis is entering a new and dangerous phase. Bedaquiline and other newer drugs have transformed drug-resistant tuberculosis treatment, yet resistance to these agents is now being reported across high-burden settings. In some regions, baseline bedaquiline res…
Raja Babu, Ayesha Juhi
… objectives Despite therapeutic advancements, patients with drug-resistant TB (DR-TB) experience substantial psychosocial challenges that adversely affect treatment adherence and outcomes. Limited research has explored these psychosocial barriers. This study aimed to explore the …
Ying Wang, Daxing Cao, Guihua Liu
…regimens for Tuberculosis (TB) primarily rely on first-line drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. Although these drugs have been pivotal in the treatment of drug-resistant tuberculosis, their high costs limit widespread use in low- and middle-income c…
Shuhao Cheng, Yuqing Wang, Jie Yao, Guodong Cheng, Gengzhi Ye, et al.
…ng treatment courses, notable toxicity and rising levels of drug resistance. By contrast, photodynamic therapy (PDT) offers a promising alternative to antibiotics. This approach employs photosensitizers (PSs), light and oxygen to generate reactive oxygen species, which induce oxi…
Diah Handayani, Muhammad Faris Indratmo, Ardiana Kusumaningrum, Ahmad Fadhil Ilham, Febriana Catur Iswanti, et al.
…This pilot study aimed to analyze the macrophage profile in drug-resistant tuberculosis patients compared to a group of close contacts diagnosed with latent infection and a group of healthy. The Interferon Gamma Release Assay (IGRA) was tested on the close contact group to determ…
T Nkomo, Z Udwadia, D Vambe, A van Rie, S S Thi, et al.
**BACKGROUND:** Strains ofwith resistance to the new and repurposed drugs included in the all-oral shorter TB regimens recommended by WHO for the treatment of multidrug-resistant/rifampicin-resistant TB (MDR/RR-TB) are becoming increasingly common globally. When strains ofhave re…
Tatiana Chiriac, Evelina Lesnic, Serghei Ghindă, Ludmila Rudi, Liliana Cepoi
… in the main study group, which included 34 cases with multidrug-resistant TB (MDR-TB), divided in the 1st study group with 12 cases with primary drug-resistance and the 2nd study group with 22 patients with acquired drug-resistance during the anti-tuberculosis treatment, and the…
Xue‐Song Xiong, Qin Zhu, Zhan-Zhong Liu, Ting-Ting Huang, Jin-Bin Fan, et al.
… clinical laboratories has been dramatically improved, multidrug-resistant M. tuberculosis (MDR-TB) is an essential cause of tuberculosis treatment failure. It is attributed to the long treatment cycle and high health care costs, resulting in a substantial social and economic bur…