Showing 26–50 of 200 documents
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Kashish Choudhary, Sana Tanweer, Mohd Zaid Choudhary, Sonam Grover
…bal TB management has become difficult due to rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) TB. Therefore, novel approaches must be developed to fight with M.tb infection. Studies on many strategies like pathogen-centric, host-directed therapeutics, anti…
Sabina Gałka
Drug resistance in bacteria and fungi is a global threat to public health. The purpose of this publication is to review the latest scientific achievements, mainly from 2020-2025, concerning the use of hemp compounds from Cannabis sativa in combating drug-resistant bacterial and f…
Alex Odoom, Abdul-Halim Osman, Christian K O Dzuvor
Antimicrobial resistance poses a grave threat to global public health. Although new antibiotics are urgently needed, most share resistance mechanisms with existing drugs, thereby necessitating the development of alternative antibacterial therapeutics. Various immunotherapeutic ag…
Mohammed Alfaqeeh, Prayudi Santoso, Jan-Willem Alffenaar, Ivan S Pradipta
Drug-resistant tuberculosis (DR-TB) continues to be a major global health threat, and while advancements in drug therapies have been made, the role of pharmacists in improving patient outcomes has not been fully optimized. This review aims to describe the types, resistance mechan…
Komal Saxena, S Shyni Carmel Mary, Prolay Ghosh, Chinnem Rama Mohan, Mohd Naved, et al.
… especially in countries with low and medium incomes. Multi-Drug Resistant Tuberculosis (MDR-TB), which is resistant to isoniazid and rifampicin, is a new type of tuberculosis that makes treatment and disease control much harder. Conventional diagnostic methods, like quantitative…
Yashna Sukdeo, Nozibusiso Pearl Shozi, Nonsikelelo Ndimande, Kingsley Chimaeze Mbara, Peter M O Owira
…void the hostile host immune defence systems and also mount resistance to chemotherapy when exposed to antibiotic stress. MTB's epigenetic survival tool-kit includes genomic DNA histone acetylation/deacetylation, methylation, phosphorylation, ubiquitylation, etc. The non-coding h…
Sandeep Rai, Abhishek Sen, Harsh Shah, Jay Patel
The emergence of drug-resistant tuberculosis (DR-TB), especially multi drug resistant tuberculosis (MDR-TB), is increasingly threatening the effectiveness of India's National TB Elimination Program (NTEP). This review seeks to analyse the patient and health system challenges conc…
Mousumi Saha, Indrani Sarkar, Arnab Sen
…sis is of prime concern to clinicians as the development of drug resistance is a common phenomenon of this pathogen. Treatment of patients particularly infected with the multi-drug-resistant and extensively drug-resistant strains are very difficult with the available pool of anti…
Zomer Sardar, Carla Y Kim, Jackson A Roberts, Safia Bano, Kiran T Thakur
**BACKGROUND:** This study aims to investigate drug resistance patterns in pulmonary and extra-pulmonary tuberculosis (TB), including central nervous system (CNS)-TB, using the largest reference multidrug resistance laboratory in Punjab, Pakistan. **METHODS:** Retrospective data…
Nandini Gupta, Ramesh K. Goyal, Bhoomika M. Patel
…ssociated with this disease is due to the presence of multi-drug-resistant bacterial strains of Mycobacterium tuberculosis. Mechanisms of drug resistance for both first-line and second-line drugs are discussed. The existing limitations of these agents are also addressed in this c…
Radha Gopalaswamy, Bhargavi Subramanian, Manisha Parthasarathy, Chandrasekaran Padmapriyadarsini, Sivakumar Shanmugam
Timely detection of drug resistance is a pre-requisite to tuberculosis management globally. While phenotypic drug susceptibility testing (pDST) by liquid or solid method takes time, current genotypic DST assays can be performed directly from clinical specimens but target only a l…
Keertan Dheda, Aliasgar Esmail, Anzaan Dippenaar, Robin M. Warren, Jennifer Furin, et al.
…lecular epidemiology, diagnosis, and clinical management of drug-resistant tuberculosis (DR-TB). Tuberculosis (TB) is far from eradicated and remains the foremost single infectious disease killer worldwide. Molecular epidemiology has played an important role in advancing our unde…
Shweta Tiwari, Ankit Kumar Singh, Aarshu Acharya, Joyabroto Ghosh, Rashmi Prabha Singh
…sis against the human defence system and the development of drugs against MTB, with particular emphasis on the mechanisms of drug resistance and mutations that render them ineffective globally. There is also a discussion of the MTB lineage and the mutant types. The mechanism…
Md Abdur Rahim, Hoonhee Seo, Indrajeet Barman, Mohammed Solayman Hossain, Md Sarower Hossen Shuvo, et al.
…tibiotics, which leads to complications such as recurrence, drug resistance, reinfection, and a range of side effects. This scenario underscores the urgent need for novel therapeutic strategies to combat this lethal pathogen. Over the last two decades, microbiome therapeutics hav…
Tushar Garg
…Given the lack of effective treatments for complicated multidrug-resistant tuberculosis (MDR-TB) and extensive drug-resistant tuberculosis (XDR-TB), it will be challenging to achieve the World Health Organization (WHO) goal to end the global TB epidemic by 2035. The treatment of …
Shashikanta Sau, Puja Kumari Agnivesh, Arnab Roy, Sunil Kumar, Nitin Pal Kalia
…neration of ATP and inhibitors can be targeted against both drug-resistant and drug-susceptible Mtb. Interestingly, under nutrient-starved and hypoxic conditions, NDH-2 expression is upregulated to sustain the energy requirements of Mtb. This adaptive regulation highlights that N…
Muhammad Sikandar, Li Xing
…veloped different mechanism of action against antimicrobial drug therapies, posing a significant threat to effective treatment against Mtb. This review article provides an overview of the recent advancements in the mechanism of drug resistance in Mtb and highlights how drugs targ…
Mpho Phehello Ngoepe, Maluta Steven Mufamadi
…al physical and chemical methods. Treatment for extensively drug-resistant tuberculosis (TB) has always been a challenge, as many patients fail to complete treatment requiring four to five active drugs over a 24-month period. Failure to identify new antimicrobials is of major con…
Antibiotic resistance poses a threat to global public health. Tuberculosis therefore continues to progress because of the emergence of multi-drug resistant strains.
Miriam Abadie, Alexander Kay
**PURPOSE OF REVIEW:** To summarize recent advances in drug-resistant tuberculosis (DR-TB) treatment for people with HIV (PWH), including drug-drug interactions, investigational medications and host-directed therapy, as well as emerging evidence on novel treatment regimens, post-…
Shahista, Jappreet Kaur, Amit Kumar Singh, Vivek Kumar Garg
Drug-resistant tuberculosis (DR-TB) is described as tuberculosis that is not responding to one or more anti-TB medications. A person is diagnosed with DR-TB if they do not respond to regular TB treatment; then a more challenging treatment regimen and a longer treatment duration a…
Remmy Shawa, Fons Coomans, Helen Cox, Leslie London
…The lack of access to effective diagnosis and treatment for drug-resistant tuberculosis (DR-TB) remains a persistent ethical, human rights and public health challenge globally. In addressing this challenge, arguments based on a Human Rights-Based Approach (HRBA) to health have mo…
Xin Mao, Jingkai Wang, Junchi Xu, Ping Xu, Huijie Hu, et al.
…global health threat, compounded by the rise of extensively drug-resistant (XDR) and multidrug-resistant (MDR) strains. This review critically examines the current landscape of laboratory diagnostic methods for MTB, encompassing both established techniques and recent advancements…
Harsha Avinash Bhute, Avinash N Bhute, Kishor B Waghulde, Bharati P Vasgi, Reshma Sonar, et al.
**BACKGROUND:** Multi-Drug Resistant Tuberculosis (MDR-TB) is a major public health problem around the world, especially in low- and middle-income countries where quick and accurate testing is needed for effective treatment and control. Traditional ways of diagnosing, like cultur…
Christian S Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins Dos Santos, Jonatas Lobato Duarte, et al.
…l health concern, particularly due to the emergence of multidrug-resistant and extensively drug-resistant strains. The persistence and propagation of TB are favored by the pathogen's sophisticated virulence mechanisms, its ability to evade immune responses, and the formation of l…