Showing 1–25 of 48 documents
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Florence Mutua, Ruey-Chyi Su, Terry Blake Ball, Sandra Kiazyk
…ype I interferon-induced transcriptomic signature in active tuberculosis suggests a potential role for these interferons in the pathogenesis of tuberculosis. Comorbidities such as human immunodeficiency virus, diabetes, systemic lupus erythematosus, end-stage renal disease, and c…
Barbara E de Bary, Marlies Heudobler, Alois Fürst, Kirsten Utpatel, Elisabeth Schuierer, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a significant global health issue, with extrapulmonary manifestations accounting for a notable proportion of cases. Perianal tuberculosis, however, is a rare presentation of TB, often leading to delayed diagnosis due to its nonspecific …
Anna Starshinova, Ekaterina Belyaeva, Olga Irtyuga, Giunai Sefiyeva, Lubov Mitrofanova, et al.
Tuberculosis remains a serious infectious disease that causes over 1.3 million deaths annually. Following the COVID-19 pandemic, the global incidence of tuberculosis has increased to 10.8 million cases. Pregnant women represent a particularly vulnerable population requiring tailo…
Stacie Burke
…ammation is the immune system's natural response to initial tuberculosis infection. Tuberculosis bacteria have gained adaptations to manipulate the inflammatory process, sometimes settling into latency and containment in granulomas, ensuring their survival. Grounded in an evoluti…
Chenxi Li, Xiangyuan Chen, Ping Zeng
Latent tuberculosis infection (LTBI) is a state of sustained immune response to Mycobacterium tuberculosis (MTB) antigens, without clinical evidence of active tuberculosis. Rheumatic diseases, a common type of autoimmune disease, are often treated with glucocorticoids, immunosupp…
Angela Hidalgo-Gajardo, Bryan Mangui, Carla Villavicencio, Jorge R Toledo, Frank Camacho
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), Bacille Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis, but it provides limited and inconsistent protection against pulmonary TB in adults. Furthermore, current diagno…
Karthikeyan Sundaram, Venkataraman Prabhu
Tuberculosis is an infectious disease spread through airborne droplet nuclei.is the etiological agent of this infection. Mycobacteria can cause active tuberculosis or asymptomatic latent infection due to its complex biology and host immunological responses. The genes of mycobacte…
Zhicong Xiang, Liuyu, Hequn Zou
…biological agents, potentially elevating the risk of latent tuberculosis infection (LTBI) reactivation and Mycobacterium Tuberculosis (MTB) dissemination. Tumor necrosis factor-α(TNF-α)is crucial in immune responses, and TNF-targeted therapies could raise the risk of …
Rajwinder Kaur, Varsha Sharma, Anju Kumari
Female genital tuberculosis (FGTB), a form of extrapulmonary tuberculosis caused by Mycobacterium tuberculosis (MTB), is an under-recognized but significant cause of female infertility, particularly in developing countries. It primarily spreads through the hematogenous route and …
Itai M Magodoro, Leigh A Kotze, Cari J Stek, Alexander West, Andrea Le Roux, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major infectious threat to global health, while type 2 diabetes mellitus (diabetes) has reached epidemic proportions in many regions of the world. In low- and middle-income countries (LMIC) and among indigenous and minority communitie…
Yuqi Ma, Xiwei Lu, Xu Cao, Xintong Lv, Jiaying Li
The comorbidity of diabetes and tuberculosis (TB) poses a major public health challenge. Patients with diabetes have impaired immune function, increasing their risk of contracting TB. They often present with atypical clinical symptoms after infection, which can lead to delayed di…
Mariana Araújo-Pereira, Bruno B Andrade
Tuberculosis infection (TBI) affects approximately one quarter of the global population and constitutes the principal reservoir sustaining future cases of tuberculosis disease (TBD). Interferon-gamma release assays (IGRAs) have become central tools for identifying TBI, particular…
Haorong Chen, Sijing Liang, Wenli Li, Ting Cao, Shujun Geng, et al.
…ines the potential of exosome analysis in diagnosing latent tuberculosis infection (LTBI). Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant public health challenge due to its high incidence worldwide. LTBI is a critical link in TB prevention and cont…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…ion of functional proteins during dormancy in Mycobacterium tuberculosis (Mtb) through in vitro experiments provides crucial insights into the bacterium's survival mechanisms and pathogenicity. Dormancy constitutes a pivotal phase in the Mtb life cycle, enabling the pathogen to p…
Sonya Krishnan, Robin Avery, Veronica Dioverti, Jeffrey A Tornheim
**PURPOSE OF REVIEW:** Tuberculosis disease (TBD) has high mortality in transplant recipients. This review evaluates the current evidence for latent tuberculosis infection (LTBI) screening and treatment in solid organ transplant (SOT) and hematopoietic stem cell transplant recipi…
Nicoleta Sorina Bertici, Talida Georgiana Cut, Amalia Ridichie, Andrei Raul Manzur, Razvan Adrian Bertici
Tuberculosis and parasitic infections, including, frequently coexist in many regions worldwide, yet their interaction remains poorly understood. Tuberculosis triggers a type 1 immune response characterized by IL-12, IFN-γ, and TNF-α production, while toxocariasis elic…
Amrish Sahney, Manav Wadhawan
India is a high endemic country for tuberculosis. The prevalence of tuberculosis rises in patients undergoing solid organ transplant with a high morbidity and mortality. Immunosuppressive drugs used after liver transplant have significant interactions with ATT necessitating chang…
Anna An Starshinova, Adilya Sabirova, Olesya Koroteeva, Igor Kudryavtsev, Artem Rubinstein, et al.
**BACKGROUND/OBJECTIVES:** Latent tuberculosis infection (LTBI) represents a critical reservoir for subsequent development of active tuberculosis (ATB) and poses significant challenges for early diagnosis and disease prevention. Traditional immunological assays, such as interfero…
Mohammed Eltahir Abdelhag, Husham E Homeida, Ogail Yousif Dawod, Abuzer Abdalla, Alfadil Ahmed Hamdan, et al.
… world's population is latently infected with Mycobacterium tuberculosis, making it a huge health issue. In spite of not having signs, many of these humans are liable to reactivation and TB, especially if weak. Controlling tuberculosis is hard considering it is uncertain which th…
Malay Sarkar
Mycobacterium tuberculosis has been known to infect humans for eons. It is an airborne infectious disease transmitted through droplet nuclei of 1 to 5 μm in diameter. Historically, tuberculosis (TB) was considered a distinct condition characterized by TB infection and activ…
Preena Prasanna, Bianca Herrera, Larry S Schlesinger, Mirko Paiardini, Riti Sharan
Tuberculosis (TB) and HIV coinfection present a significant global health challenge worldwide. While most individuals infected with Mycobacterium tuberculosis (Mtb) have clinically asymptomatic latent TB infection (LTBI), those with immunosuppressive conditions, such as HIV, are …
Amitesh Gupta, Eshutosh Chandra, Shipra Anand, Naresh Kumar, Richa Arora, et al.
…mination of the contemporary landscape pertaining to latent tuberculosis infection (LTBI) diagnostics, with a particular emphasis on the global ramifications and the intricacies surrounding LTBI diagnosis and treatment. It accentuates the imperative of bolstering diagnostic, prev…
Fedor D Kireev, Julia A Lopatnikova, Alina A Alshevskaya, Sergey V Sennikov
…ting the molecular and cellular mechanisms of TNF action in tuberculosis (TB). Particular attention is given to TNF receptor signaling pathways, the balance between protective and pathological immune responses, and the modulation of TNF activity during anti-TNF therapy in patient…
Stacie Burke
…ro-inflammatory switches are risks for latent Mycobacterium tuberculosis (Mtb) reactivation and ongoing infection transmission. This paper considers the heavy toll of reactivation risk in Indigenous communities in Canada and the chronic, everyday pro-inflammatory stressors connec…
Aigul Utegenova, Lazzat Kassayeva, Bayan Turdalina, Aliya Baiduissenova, Ayaz Yktiyarov, et al.
Latent tuberculosis infection (LTBI) represents a major global health concern as it constitutes the principal reservoir for future tuberculosis (TB) disease. Its identification is particularly important in Bacille Calmette-Guérin (BCG)-vaccinated populations, where cross-rea…