Showing 176–200 of 200 documents
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Guangtian Liu, Jufen Lv, Linlin Chen, Yinglong Ma, Bofei Liu, et al.
…udy, we aimed to investigate the epidemiological profile of tuberculosis (TB) and the genotype characteristics of Mycobacterium tuberculosis (MTB) in the Ningxia Hui Autonomous Region, China. **METHODS:** From 2005 to 2023, to provide a scientific basis for the precise preventio…
Maciej Michalik, Tomasz Lorenc, Krzysztof Marcinkowski, Mateusz Muras, Natalia Mikszta, et al.
Drug-resistant tuberculosis (DR-TB) poses a significant global health threat, particularly in low- and middle-income countries with limited access to quality healthcare. By 2023, 10% of global tuberculosis cases were classified as drug-resistant, with multidrug-resistant (MDR-TB)…
Sameeullah Memon, Shabana Bibi, Guozhong He
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Despite the improvements in diagnostic techniques, the accuracy of TB diagnosis is still low. In recent years, the development of artificial intelligence (AI) has opened up new possibilities in diagn…
Anna An Starshinova, Adilya Sabirova, Olesya Koroteeva, Igor Kudryavtsev, Artem Rubinstein, et al.
**BACKGROUND/OBJECTIVES:** Latent tuberculosis infection (LTBI) represents a critical reservoir for subsequent development of active tuberculosis (ATB) and poses significant challenges for early diagnosis and disease prevention. Traditional immunological assays, such as interfero…
Hindol Maity, Supriya Meshram, Keshao Hiwale, Pratibha Narang
Zoonotic tuberculosis (zTB), a form of human tuberculosis caused by animal-adapted members of thecomplex (MTBC), poses unique challenges for clinical diagnosis, surveillance, and public health control. Traditionally associated withand transmitted through the consumption of unpast…
Luyan Xiong, Qiao Zhang, Abulimiti Abudukadier, Jianping Xie
Tuberculosis (TB) is a severe infectious disease caused by Mycobacterium tuberculosis (Mtb). Host innate immunity plays a critical role in controlling Mtb infection, in which the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome serves as a key intracellular…
Amrish Sahney, Manav Wadhawan
India is a high endemic country for tuberculosis. The prevalence of tuberculosis rises in patients undergoing solid organ transplant with a high morbidity and mortality. Immunosuppressive drugs used after liver transplant have significant interactions with ATT necessitating chang…
Zomer Sardar, Carla Y Kim, Jackson A Roberts, Safia Bano, Kiran T Thakur
…e drug resistance patterns in pulmonary and extra-pulmonary tuberculosis (TB), including central nervous system (CNS)-TB, using the largest reference multidrug resistance laboratory in Punjab, Pakistan. **METHODS:** Retrospective data from 2012 to 2022 were collected from 1410 p…
Anita Saibannavar, Gurjeet Kaur, Nitin Kumbhar
**INTRODUCTION:** Drug resistant Tuberculosis (DR-TB) continues to be a major concern for public health, particularly in countries like India with high disease burden. Recognizing resistance trends and appropriate therapeutic approach is critical for improving patient outcomes an…
Rasmus Mortensen, Cecilia S Lindestam Arlehamn, Rhea N Coler, Michael Y Gerner, Delia Goletti, et al.
Tuberculosis (TB) remains a leading infectious cause of morbidity and mortality, and the development of a new, highly effective vaccine would have a tremendous beneficial impact on global health. Although conventional memory CD4 and CD8 T cells will likely be key mediators of lon…
Pragati Pandit, Sanjay Thorat, Shilpy Singh, Sejal D'mello, Geeta Padole Gaikwad, et al.
…with digital microscopy is important for the improvement of tuberculosis diagnosis in communities or populations where expert annotations are not available. In this paper, we propose a semi-supervised graph-based learning approach with label spreading and effectively make use of …
Rajiv Garg, Shubham Shukla, Ravindra Kumar Garg
Central nervous system (CNS) tuberculosis is one of the most severe forms of extrapulmonary TB, often leading to substantial morbidity and mortality owing to its complex clinical presentation and frequent diagnostic delays. Despite global TB control efforts, CNS TB continues to p…
Jiaxiang Li, Yilin Liu, Yongdui Ruan, Xinen Kong, Xiaoying Jin, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global public health issue, despite improvements in socioeconomic conditions and widespread use of antibiotics. Host immune defense against Mtb infection involve various cells like macrophages, dendrit…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Tuberculosis (TB) remains one of the world's most urgent public health challenges, with a substantial global burden that continues to affect millions annually. According to the World Health Organization (WHO) Global Tuberculosis Report 2024, approximately 10.6 million people deve…
Caden W Munson, Deepak Kaushal
Mycobacterium tuberculosis (Mtb) remains an epidemiological concern due to heterogeneous outcomes in tuberculosis (TB) pathology and the lack of mechanistic understanding of early immune events. Type I interferons (IFNs) in TB are generally described as pathological. However, evi…
Preena Prasanna, Bianca Herrera, Larry S Schlesinger, Mirko Paiardini, Riti Sharan
Tuberculosis (TB) and HIV coinfection present a significant global health challenge worldwide. While most individuals infected with Mycobacterium tuberculosis (Mtb) have clinically asymptomatic latent TB infection (LTBI), those with immunosuppressive conditions, such as HIV, are …
Eshet Gebrie, Habtamu Wondifraw Baynes, Birhan Mulugeta, Henok Worku, Berihun Agegn Mengistie, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, exhibits pronounced sex differences in incidence and disease progression, with adult males disproportionately affected. Increasing evidence indicates that sex steroid hormones estrogen, progesterone, and testosterone modula…
Nazia Ahmad, Zeyaul Islam, Sohan Dhar, Pankaj Kumar, Rana Zaidi
Tuberculosis (TB), caused by the infectious agent Mycobacterium tuberculosis (Mtb), has resulted in the highest mortality rates, even surpassing HIV/AIDS. The rise of Drug-resistant TB has worsened the health crisis and urgently requires new treatment approaches. The WHO has appr…
Malay Sarkar
Mycobacterium tuberculosis has been known to infect humans for eons. It is an airborne infectious disease transmitted through droplet nuclei of 1 to 5 μm in diameter. Historically, tuberculosis (TB) was considered a distinct condition characterized by TB infection and activ…
Qamar Abuhassan, Mohamed Abu Shuheil, Narinderjit Singh Sawaran Singh, Praharshkumar B Raj, Subbulakshmi Ganesan, et al.
The persistent global burden of tuberculosis (TB) and the context-dependent efficacy of the Bacillus Calmette-Guérin (BCG) vaccine necessitate the development of innovative prophylactic strategies. mRNA vaccine platforms have emerged as a transformative toolkit, offering unp…
Akriti Gaurav, Saif Hameed, Amit Kumar Singh, Zeeshan Fatima
**BACKGROUND:** Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to pose a serious global health threat, especially with the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Progress in developing new therapeutics relies on preclin…
Jambi Ratna Raja Kumar, Laxmi Bewoor, Kalyani Kadam, Sunil M Sangve, Mayuri B Satpute
Tuberculosis is a disease with many phenotypes, complicated by the hierarchical clinical taxonomies of drug resistance that are not typically leveraged in existing predictive modeling. We developed a taxonomy-driven, hierarchical classification framework trained on a large and di…
Amit Sharma, Poulomi Chatterjee, Shashank Shastry
…oimidazole group of drugs. Drug resistance in Mycobacterium Tuberculosis (MTB) is an ever changing, continuous and evolving process whereby the bacteria finds new genetic mutations to escape destruction by the newer drugs. DLM and PRT belong to the same class of drugs and resista…
Pierre Dupuy, Sarah C Monard, Olivier Neyrolles, Geanncarlo Lugo-Villarino
…ets related to nerves and blood vessels, whose functions in tuberculosis are mostly unexplored but could signify potential new research opportunities. Altogether, this review highlights that a better understanding of the ontogeny and location of a macrophage is as important as co…
Liya Zhu, Jinzhi Lu, Yanfei Chen
…gocytic lymphohistiocytosis (HLH) secondary to disseminated tuberculosis (TB) is a rare, life-threatening hyperinflammatory syndrome. We present a 60-year-old man with recurrent fever and syncope. Workup revealed cytopenias, hyperferritinemia (peak 5,802 ng/mL), elevated C-reacti…