Showing 1–25 of 152 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Vinay Jasani, Ahmed Abdelaal, Mohamed Mohamed
…eption of the first antituberculous chemotherapeutic agent, drug resistance has been one of the most challenging problems facing the global fight to control tuberculosis. Drug resistance to antituberculous chemotherapy is a spectrum which includes mono-drug resistance (e.g. rifam…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
The emergence of drug-resistant tuberculosis jeopardizes the TB control programme activities globally. Multidrug-resistant TB is defined as tuberculosis strains resistant to at least two first-line drugs, rifampicin (RIF) and isoniazid (INH). Extensively drug-resistant TB refers …
Apoorva Narain, Surya Kant, Rikesh K. Dubey, Kanchan Srivastava, Anand Kumar Maurya
…onential increase in tuberculosis (TB) cases, mainly by the drug-resistant (DR) strains of MTB, has created an urgent need for identifying and developing new antituberculosis drugs acting via novel mechanisms. The multi drug-resistant (MDR) TB and extensively drug-resistant (XDR)…
Mani Sharma, Sakshi Kansal
…are numerous factors responsible for the emergence of multi-drug resistance and extensively drug resistance cases of tuberculosis, which involves high pill burden, prolonged treatment, low compliance, and stiff administration schedules. Continuous efforts have been done to develo…
Usharani Brammachary, Venkateswari Ramachandra, Suganthi Palavesam, Vidya Raj Cuppusamy Kapalamurthy, Aaina Muralidhar, et al.
…ry TB regimens consist of 6–9 months of daily doses of four drugs in the existing regimen that is extremely toxic to patients. The purpose of these longer treatments is to eliminate Mycobacterium tuberculosis, notorious for its ability to resist most antimycobacterial drugs, ther…
Tanzila K. Chowdhury, Laurence A. F. Park, Glenn Stone, Mark M. Tanaka, Andrew Francis
…lly and is exacerbated by a growing problem with antibiotic drug resistance. To control the spread of such resistance, it is important for public health authorities to know whether drug-resistant strains in their population have arisen from the ineffective treatment of a previous…
Lynn Sosa, Lloyd N. Friedman
…l location of the treatment facility. The usual therapy for drug-sensitive tuberculosis (TB) comprises four drugs for 2 months, dropping ethambutol once the organism is known to be sensitive to isoniazid, rifampin, and pyrazinamide; then continuing maintenance isoniazid and rifam…
Rafael Laniado-Laborı́n
The presence of drug resistance should always be suspected when there are risk factors for it and must be confirmed by bacteriological or molecular tests for standardized drug sensitivity. Any regimen for drug-resistant TB is more likely to be effective if its composition is base…
Piyushkumar Sadhu, Mamta Kumari, Niyati Shah, Chitrali Talele, Nirmal Shah, et al.
Drug-resistant tuberculosis, particularly those with rifampicin resistance (RR-TB), has emerged as one of the major challenges to the goal of eliminating tuberculosis. Additionally, three or four different medications must be used in an effort to treat TB, but sadly, there aren't…
Drug-resistant tuberculosis is a re-emerging public health concern which requires special attention all around the world.Among all the infectious diseases, drug-resistant tuberculosis is now the most lethal infection causing disease in both children and adults.The co-infection of…
Mousumi Saha, Indrani Sarkar, Arnab Sen
…sis is of prime concern to clinicians as the development of drug resistance is a common phenomenon of this pathogen. Treatment of patients particularly infected with the multi-drug-resistant and extensively drug-resistant strains are very difficult with the available pool of anti…
Nandini Gupta, Ramesh K. Goyal, Bhoomika M. Patel
…ssociated with this disease is due to the presence of multi-drug-resistant bacterial strains of Mycobacterium tuberculosis. Mechanisms of drug resistance for both first-line and second-line drugs are discussed. The existing limitations of these agents are also addressed in this c…
Keertan Dheda, Aliasgar Esmail, Anzaan Dippenaar, Robin M. Warren, Jennifer Furin, et al.
…lecular epidemiology, diagnosis, and clinical management of drug-resistant tuberculosis (DR-TB). Tuberculosis (TB) is far from eradicated and remains the foremost single infectious disease killer worldwide. Molecular epidemiology has played an important role in advancing our unde…
Tushar Garg
…Given the lack of effective treatments for complicated multidrug-resistant tuberculosis (MDR-TB) and extensive drug-resistant tuberculosis (XDR-TB), it will be challenging to achieve the World Health Organization (WHO) goal to end the global TB epidemic by 2035. The treatment of …
Mpho Phehello Ngoepe, Maluta Steven Mufamadi
…al physical and chemical methods. Treatment for extensively drug-resistant tuberculosis (TB) has always been a challenge, as many patients fail to complete treatment requiring four to five active drugs over a 24-month period. Failure to identify new antimicrobials is of major con…
Antibiotic resistance poses a threat to global public health. Tuberculosis therefore continues to progress because of the emergence of multi-drug resistant strains.
Shahista, Jappreet Kaur, Amit Kumar Singh, Vivek Kumar Garg
Drug-resistant tuberculosis (DR-TB) is described as tuberculosis that is not responding to one or more anti-TB medications. A person is diagnosed with DR-TB if they do not respond to regular TB treatment; then a more challenging treatment regimen and a longer treatment duration a…
Remmy Shawa, Fons Coomans, Helen Cox, Leslie London
…The lack of access to effective diagnosis and treatment for drug-resistant tuberculosis (DR-TB) remains a persistent ethical, human rights and public health challenge globally. In addressing this challenge, arguments based on a Human Rights-Based Approach (HRBA) to health have mo…
Simon Tiberi, Temi Lampejo, Alimuddin Zumla
Rifampicin-resistant Tuberculosis (RR-TB) and Multidrug resistant Tuberculosis (MDR-TB) are a current global health threat, and are characterised by high mortality, chronic sequelae, complexity and high cost. The drug resistant form of this infectious disease was globally respons…
Gyanshankar Mishra
Multidrug-resistant tuberculosis (MDR-TB) is tuberculosis that is resistant to at least rifampicin and isoniazid, which threatens to erode the current progress in the global control of TB. Drug resistance may further worsen with the appearance of drug resistance to at least one o…
Tatiana Chiriac, Evelina Lesnic, Serghei Ghindă, Ludmila Rudi, Liliana Cepoi
… in the main study group, which included 34 cases with multidrug-resistant TB (MDR-TB), divided in the 1st study group with 12 cases with primary drug-resistance and the 2nd study group with 22 patients with acquired drug-resistance during the anti-tuberculosis treatment, and the…
Xue‐Song Xiong, Qin Zhu, Zhan-Zhong Liu, Ting-Ting Huang, Jin-Bin Fan, et al.
… clinical laboratories has been dramatically improved, multidrug-resistant M. tuberculosis (MDR-TB) is an essential cause of tuberculosis treatment failure. It is attributed to the long treatment cycle and high health care costs, resulting in a substantial social and economic bur…
G. Mac-Fiberesima, SD Abbey, C. K. Wachukwu, O. Azuonwu
Tuberculosis is a life-threatening infectious disease that is responsible for the death of most people all over the world. It is characterized by coughing, fever, night sweats and loss of weight due to the pathology of Mycobacterium tuberculosis that causes the disease. In some c…
Andrew Woodhouse
Multi-drug resistant tuberculosis (MDR-TB) is defined by resistance to both isoniazid and rifampicin, the two most effective first line anti-tuberculous drugs. Resistance to one or other drug plus resistance to other first line agents (streptomycin, pyrazinamide and ethambutol) r…
Meenakshi Jain, Himanshu Sharma, Menka, Tushar Dash, Rehan Hamdulay, et al.
…s annually. Despite progress in treatment, the emergence of drug-resistant strains, including multidrugresistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), poses challenges to effective management, thus necessitating the development of novel medications. Nitroimidazo…