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Lin KY, Sun HY, Yang CJ, Lu PL, Lee YT, et al.
…erience with combinations of short-course rifapentine-based regimens and integrase strand-transfer inhibitor-containing antiretroviral therapy (ART) in management of latent tuberculous infection (LTBI) is limited among people with human immunodeficiency virus (PWH). Methods From …
Qiaoling Ruan, Jingyu Zhou, Shufeng Weng, Lingyun Shao, Wenhong Zhang
…ts. The World Health Organization recommends LTBI treatment regimens, including 6 or 9 months of once-daily isoniazid (INH, H), 4 months of once-daily rifampin (RIF, R), 3 months of once-weekly rifapentine (RPT, P) plus INH (3HP), 3 months of once-daily RIF plus INH, or 1 month o…
Aliya Moreira, Dana Hassneiah, Susan E. Beekmann, Philip M. Polgreen, Maunank Shah, et al.
…e 2020, CDC guidance has preferentially recommended shorter regimens for tuberculosis (TB) infection and since 2022, recommendations include 6-month regimens for drug-resistant (DR-TB) disease containing bedaquiline, linezolid, and pretomanid (BPaL) and a 4-month regimen for drug…
Ilangovan Ilavarasan, Vidhyanathan Ariharanathan, Chandrasekaran Sabitha Devi
…CI). Conclusion: The weekly HP regimen is superior to other regimens in reducing the incidence of TB. Additionally, the duration of the HP regimen is shorter compared to the commonly advised nine-month Isoniazid regimen. Compared with the daily dosage of Isoniazid, the weekly HP …
Wolfe A, Jadhav P, May A, Seymour S, Blanchard A, et al.
…d with each regimen. Overall, rifampin-containing shortened regimens are the preferred modality for LTBI treatment. A recent study in 2023 evaluated adherence and tolerance of the isoniazid(INH) + rifapentine(RPT), or "3HP" regimen and identified patient groups that may be at hig…
Gao L, Zhang H, Xin H, Liu J, Pan S, et al.
… Registry identifier ChiCTR-IOR-15007202), two short-course regimens with rifapentine plus isoniazid (a 3-month once-weekly regimen and a 2-month twice-weekly regimen) were initially designed to be evaluated for rural residents aged 50-69 years with LTBI in China.Due to the incre…
Wheeler C, Mohle-Boetani J
…16%) than among nonincarcerated persons (6%). We compared 2 regimens to treat LTBI in an adult prison population in California: 9 months of twice-weekly isoniazid (9H; previous standard of care) and 12 once-weekly doses of isoniazid and rifapentine (3HP; introduced in 2011). Meth…
Villa S, Ferrarese M, Sotgiu G, Castellotti PF, Saderi L, et al.
…either isoniazid (INH) alone or rifampicin (RIF)-containing regimens. This study aims to assess and compare PT completion rates, the occurrence of adverse events, and the time of dropout among those receiving INH-alone or RIF-containing regimens at Villa Marelli Institute, Milan,…
Doan TN, Fox GJ, Meehan MT, Scott N, Ragonnet R, et al.
…erefore LTBI treatment is key for TB elimination. Treatment regimens for LTBI include self-administered daily isoniazid for 6 (6H) or 9 (9H) months, self-administered daily rifampicin plus isoniazid for 3 months (3RH), self-administered daily rifampicin for 4 months (4R) and week…
Feng PI, Horne DJ, Wortham JM, Katz DJ
… for Disease Control and Prevention has recommended shorter regimens-12 weeks of isoniazid and rifapentine or 4 months of rifampin-because they have similar efficacy, better tolerability, and higher treatment completion than 6-9 months of isoniazid. The objective of this analysis…
Anthony Harries, Kudakwashe C Takarinda
BACKGROUND: Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.METHODS: In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmo…
Gavin Koh
BACKGROUND: Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.METHODS: In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmo…
Soedarsono Soedarsono
… well as changes in the grouping of medicines used in DR-TB regimens in longer/individual regimens. Bedaquiline, delamanid, pretomanid, and sutezolid are new drugs which have been studied for their uses as anti-TB drugs (ATD). Bedaquilin and delamanid, which have passed phase 3 t…
Joana Marques Simões, Dalila Ferreira, Teresa Mourato, Ana Pais, André Dias, et al.
… of adverse events. The shorter duration of rifamycin-based regimens has become increasingly preferable. The one month of daily rifapentine plus isoniazid (1HP) has demonstrated low toxicity and higher completion rates in HIV-infected populations. This study aims to compare the c…
Pangprasertkul S, Buawangpong N, Pinyopornpanish K, Jiraporncharoen W, Angkurawaranon C
Background Children and adolescents are at increased risk of progressing from latent to active tuberculosis (TB). The 3-month, once-weekly isoniazid and rifapentine (3HP) regimen offers a shorter tuberculosis preventive treatment (TPT) option. However, evidence regarding its comp…
Hannah Tan, Arlene Dy-Co
…currently available Latent Tuberculosis Infection treatment regimens, 6 months isoniazid (6H) and 3 months isoniazid plus rifampicin (3HR), based on the 2020 Department of Health National Tuberculosis Control Program Tuberculosis Preventive Treatment guidelines for children. Meth…
Jacques Simkins, Yoichiro Natori, Shweta Anjan, Giselle Guerra, Rodrigo Vianna
…hs is more likely to cause liver toxicity compared to other regimens and its rate of completion can be lower than 50%. As of result of this, there has been a shift in the treatment of LTBI. The following short-regimens: 3 months of weekly isoniazid plus rifapentine, 4 months of d…
Shahid NUA, Naguit N, Jakkoju R, Laeeq S, Reghefaoui T, et al.
…he effectiveness, safety, and completion of any of the five regimens available for latent tuberculosis infection. These options are the most classic and standard nine months of isoniazid given daily, which is now more commonly given as six months course, three months of daily iso…
Hualin Jiang, Rui Li, Tianhua Zhang, Qinghu Wang, Haini Liu, et al.
…ss ratios (ICER) of this optimal TPT strategy with five TPT regimens (isoniazid monotherapy with two different durations, rifampin monotherapy, and combinations of isoniazid with rifampin or rifapentine) over 2025-2050, compared with no TPT, from a health system perspective. A wi…
Julian Surey, Helen R. Stagg, Thomas A Yates, Marc Lipman, Peter J White, et al.
…(LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety…
Peng TR, Chen JH, Chang YH, Shiang JC, Lee MC, et al.
… incident tuberculosis or the completion rates of treatment regimens were included. The Cochrane Collaboration tool was used to assess the risk of bias. We tested for possible global inconsistency with a χ 2 test and local inconsistency by calculating inconsistency factors for ea…
Borisov AS, Bamrah Morris S, Njie GJ, Winston CA, Burton D, et al.
…that 3HP is as safe and effective as other recommended LTBI regimens and achieves substantially higher treatment completion rates. In July 2017, the Work Group presented the meta-analysis findings to a group of TB experts, and in December 2017, CDC solicited input from the Adviso…
Surey J, Stagg HR, Yates TA, Lipman M, White PJ, et al.
…(LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety…
Campos-Outcalt
… for Disease Control and Prevention detail 3 shorter-course regimens that take no more than 4 months. In this month’s audiocast, Dr. Campos-Outcalt describes the regimens and who should be screened for TB.
Meenu Singh, Kulbir Kaur, Anil Chauhan, Manvi Singh, HarnoorKaur Sra, et al.
…e efficacy and safety of isoniazid (INH) versus alternative regimens for preventing active tuberculosis in children. Methods: A detailed analysis of the randomized controlled trials, methodology, interventions, and outcomes was done. Electronic searching was done through differen…