Showing 1–25 of 31 documents
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SushantSatish Mane
Childhood tuberculosis (TB) is a grave problem, with nearly one-third of global pediatric TB cases being from India. In 2020, approximately one lakh TB cases (0–14 years of age) were reported to the National TB Elimination Program (NTEP), with around 1.4 lakh cases in the 15–18 y…
Gaurav Sharma, Bharti Malhotra, P. J. John, Shipra Bhargava
…ain purpose of this study is the detection of Mycobacterium tuberculosis (MTB) and its drug resistance profile by molecular methods in pediatric patients suspected of pleural tuberculosis. Children ≤ 15 years of age suspected of pleuritis were enrolled in this study. Total 176 pl…
Mi Zhou, Xuren Chen, Jie Huang, Runlin Su, Hongmei Lei, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) management remains an underemphasized area plagued by diagnostic and treatment challenges that are compounded further due to rising levels of drug-resistant tuberculosis (DR-TB). Even though TB incidence is high in China, limited data e…
Khurana P, Saigal K, Ghosh A
…lar tests like GenoType MTBDRplus has revolutionized MDR-TB diagnosis by rapid detection of resistance, leading to early and appropriate management of DR-TB. Information about common mutations imparting resistance to RIF and INH, helps in understanding the disease epidemiology in…
Ambreen Shaikh, Camilla Rodrigues
…ction Methods in Children and Their Diagnostic Accuracy for Tuberculosis Detection Sample collection in children to detect tuberculosis (TB) is a vital consideration in achieving a microbiologic diagnosis.1 In children who have difficulty expectorating sputum, particularly those …
Sharma S, Sarin R, Sahu G, Shukla G
Background Pediatric tuberculosis (TB) constitutes 8% of the total caseload of TB. Children are particularly vulnerable to dissemination of disease and mortality. Aim To determine mortality rate, elucidate type of TB, causes and predictors of mortality, if any, in admitted pediat…
О. М. Raznatovska, V.I. Petrenko, О.S. Shalmin, R.M. Yasinskyi, A.V. Fedorec, et al.
We present our own observation of the multifocal tuberculosis with pre-extensive drug resistance (pre-XDR-TB) development in a patient who was treated in the pulmonary tuberculosis department No. 2 of the Zaporizhzhia’ regional phthisio-pulmonology clinical treatment and diagnos…
M. Santhana Kumar, M. Arhoul Rennies, Rajeshwari Sivaraj, R Sneha, S. Vennila
Background: Tuberculosis (TB) remains a major global public health challenge, presenting primarily as pulmonary TB (PTB) or, less commonly, as extra pulmonary TB (EPTB). Objectives: This study aimed to: (1) document the clinical symptoms of PTB and EPTB; (2) identify associated r…
Mursheda Akter, Samrein B. M. Ahmed
Background: Bangladesh is ranked 6th among the Tuberculosis high burden countries. Sometimes, pulmonary tuberculosis (PTB) mimics the early symptoms of lung cancer. Developing countries like Bangladesh, with limited diagnostic facilities, often misdiagnose early lung cancer as sm…
Neil Sharma, Manish Singhal, Rachana Agrawal, Manoj Kumar Sharma, Sona Goyal
Context: Tuberculosis is a major health problem in India .Accurate and also fast diagnosis of tuberculosis has remained a challenge and we determined the impact of CBNAAT on notification of tuberculosis cases in Rajasthan. Aims: The Aim of the present Study was use of CBNAAT in t…
Dhruv Gandhi, Shatakshi Garg, Sonal Patil, Dhruv Mamtora, Ira Shah
Abstract Background The microbiological diagnosis of tuberculosis (TB) has evolved from conventional methods like culture and phenotypic drug-sensitivity testing (pDST) to rapid molecular assays such as line probe assays (LPA), Xpert MTB/Rif, Xpert Ultra, and Xpert MTB/XDR. While…
Yin Mon Thant
Tuberculosis (TB) is well known as a major infectious disease and one of the top 10 causes of death worldwide. TB can affect anyone, everywhere but it has a predilection for those with diabetes, human immunodeficiency virus (HIV), smoking and undernutrition. Myanmar, with 54 mill…
Supriya Dhakne
Introduction: Multidrug‑resistant tuberculosis (MDR‑TB) has created a significant health problem in most of the countries, and it is an obstacle to effective TB control. Aims and Objectives: The study aims to study the prevalence of MDR‑TB among new cases, retreatment cases and t…
Olena Oliveira, Rita Gaio, Teresa Rito, Margarida Correia‐Neves, Raquel Duarte
Treatment of drug-resistant tuberculosis (TB) has become a major challenge for TB control worldwide and treatment outcomes are often suboptimal. Overall, the death rate reported by WHO was 15% among patients with multidrug-resistant tuberculosis (MDR-TB) and 26% among patients wi…
Anita Kumari, Parveen Sharma, Rekha Bansal
…ercular drugs and may result in to extensive drug resistant tuberculosis (XDR-TB) and major challenges for successful outcome. Objective was to study treatment outcome of multi-drug resistant tuberculosis patients on second line anti-tuberculosis drugs at tertiary care hospital a…
Mahaman Laouali Harouna Amadou, Ibrahim Maman Lawan, Abdoulaye Ousmane, Abdoul Kadir Ibrahim Mamadou, AMADOU, Oumarou, et al.
…ile of patients followed for rifampicin-resistant pulmonary tuberculosis (RR-TB) at the Regional Hospital Centre (RHC) of Maradi (Niger) from 2014 to 2018. Methods: We conducted a retrospective and descriptive study based on the records of patients followed for Multidrug-resistan…
О.С. Шевченко, Svitlana Matveyeva, Anna Stepanenko, Olexandra Choporova, Olha Pohorielova
PECULIARITIES OF DRUG-RESISTANT TUBERCULOSIS IN UKRAINE AND KHARKIV REGION 
 Shevchenko O., Matveyeva S., Stepanenko A., Choporova O., Pohorielova O.
 Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problem…
E. A. Krushinskaya, Л. В. Панова, V. V. Bereznitskaya, E. S. Ovsyankinа, О. А. Пискунова
The article describes a clinical case of delayed diagnosis of bilateral advanced destructive pulmonary TB with extensive drug resistance (XDR) in an adolescent. Effective and safe prolonged use of bedaquiline (Bq) in the complex treatment was demonstrated. A multidisciplinary app…
Gina Oda, Cynthia Lucero‐Obusan, Patricia Schirmer, Mark Holodniy
…iazid (INH)-resistant and multidrug-resistant Mycobacterium tuberculosis (MDR-TB, ie, resistant to at least INH and rifampin) represented 9.3% and 1.5% of TB cases, respectively, in the United States. Objective: We analyzed the prevalence of drug-resistant TB within the Veterans …
Vibha Mehta, Puneet Kumar Gupta, Mukesh Bairwa, Jakkula Sam Rahul
…ow no boundaries, severe global epidemics of drug resistant tuberculosis (DR-TB) pose a great health crises. Globally, World Health Organization (WHO) estimates that there are 484,000 new cases with resistance to first line drug rifampicin, of which 78% have MDR-TB (Multi drug re…
Sarika Gupta, Mala Kumar, S. N. Singh, Shalini Tripathi, Sakshi Singh, et al.
Abstract Congenital tuberculosis (TB) is an uncommon yet severe form of TB, where the diagnosis and management are challenging due to nonspecific clinical manifestations. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB) shows resistance to at least one fluoroquinolone alo…
Zulfiya Haybullo Tilloeva, Roberta Horth, A. S. Mirzoev, Rajabali Sharifov, Dilyara Nabirova, et al.
…. Treatment delay was defined as >3 days from MDR-TB diagnosis to treatment initiation. MDR-TB confirmation was based on molecular tests (including line probe assay and GeneXpert) and phenotypic drug sensitivity tests. We calculated treatment delay percentage by group and …
О. М. Raznatovska, А. В. Федорец, O. O. Furyk, H. I. Makurina, T. O. Hrekova, et al.
…ta with the clinical features of extensively drug-resistant tuberculosis (XDR-TB), HIV and tertiary syphilis co-infection course based on an example from own clinical experience.Materials and methods. A case report of XDR-TB with HIV and tertiary syphilis co-infection course was …
Gaurav Sharma, Bharti Malhotra, Paget John, Shipra Bhargava
…d to detect the incidence of tuberculous meningitis (TM) in pediatric patients using GenoType MTBDRplus, GenoType MTBDRsl, and Mycobacteria Growth Indicator Tube (MGIT). Additionally, it aimed to evaluate the utility of GeneXpert MTB/RIF assay in the detection of Mycobacterium tu…
David S.C. Hui, Chi Chiu Leung
…tions (RTI), such as community-acquired pneumonia (CAP) and tuberculosis (TB), are important causes of morbidity and mortality. The ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) infection and epidemic waves of avian influenza A(H7N9) since their eme…