Showing 1–25 of 104 documents
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Mi Zhou, Xuren Chen, Jie Huang, Runlin Su, Hongmei Lei, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) management remains an underemphasized area plagued by diagnostic and treatment challenges that are compounded further due to rising levels of drug-resistant tuberculosis (DR-TB). Even though TB incidence is high in China, limited data e…
Letícia Baltar Sobreira, Paula de Souza Silva Freitas, Luciana de Cássia Nunes Nascimento, Anne Caroline Barbosa Cerqueira Vieira, Carolina Maia Martins Sales, et al.
…cessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: “What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis in…
Sharma S, Sarin R, Sahu G, Shukla G
Background Pediatric tuberculosis (TB) constitutes 8% of the total caseload of TB. Children are particularly vulnerable to dissemination of disease and mortality. Aim To determine mortality rate, elucidate type of TB, causes and predictors of mortality, if any, in admitted pediat…
Shah I, Antony S, Jaiswal A, Bodhanwala M, Shah D, et al.
…ptimized background regimen including Dlm or Bdq or both in pediatric MDRFQ/SLI/XDR-TB patients who failed a standard MDR-TB regimen under the National Tuberculosis Elimination Programme in Mumbai, India. Design and methods Retrospective descriptive analysis study. National Tuber…
Yulia Khokhlova, М. Ф. Губкина, Natalya Yukhimenko, I. Yu. Petrаkovа, С. С. Стерликова
… on the use. To decide on the safety of fluoroquinolones in pediatric TB, it is important to assess benefits versus risks of adverse events. <b>Aim:</b> To study efficacy and safety of fluoroquinolones in the treatment for MDR/XDR TB in children. <b>Materials and methods:</b> We …
Wang T, Dong F, Li QJ, Yin QQ, Song WQ, et al.
…s and characteristics of drug resistance in newly diagnosed pediatric tuberculosis (TB) patients in northern China. Methods Mycobacterium tuberculosis isolates were collected from September 2010 to October 2016 at the Beijing Children's Hospital. Patients were divided into two gr…
SushantSatish Mane
…is (TB) is a grave problem, with nearly one-third of global pediatric TB cases being from India. In 2020, approximately one lakh TB cases (0–14 years of age) were reported to the National TB Elimination Program (NTEP), with around 1.4 lakh cases in the 15–18 years age group.[1] O…
Gaurav Sharma, Bharti Malhotra, P. J. John, Shipra Bhargava
…TB) and its drug resistance profile by molecular methods in pediatric patients suspected of pleural tuberculosis. Children ≤ 15 years of age suspected of pleuritis were enrolled in this study. Total 176 pleural fluid samples were collected from January to June 2018 and tested for…
Shah MA, Shah I
Background The prevalence and type of Drug resistant tuberculosis (DR-TB) was evaluated pre- and post-2013, and outcome was studied. Methods Descriptive retrospective study. Children were defined as having DR-TB on the basis of GeneXpert or line probe assay and/or drug susceptibi…
Khurana P, Saigal K, Ghosh A
Background The emergence of multidrug-resistant MDR-TB and extensively drug-resistant XDR-TB are serious threats to global TB control. Molecular tests like GenoType MTBDRplus has revolutionized MDR-TB diagnosis by rapid detection of resistance, leading to early and appropriate ma…
Sharma S
The WHO's End TB Strategy and the United Nations' (UN) Sustainable Development Goals (SDGs) share the common aim to end the global TB epidemic. Specific targets have been set in the End TB Strategy, for the period 2016-2035, which include a 90% reduction in TB deaths and an 80% r…
Peter J. Holmberg, Zelalem Temesgen, Ritu Banerjee
…em Temesgen, MD† 3. Ritu Banerjee, MD, PhD‡ 1. *Division of Pediatric Hospital Medicine, Department of General Pediatric and Adolescent Medicine, and 2. †Division of Infectious Disease, Mayo Clinic, Rochester, MN 3. ‡Division of Pediatric Infectious Diseases, Department of Pediat…
Ambreen Shaikh, Camilla Rodrigues
…mmended Xpert Ultra (Cepheid) testing of stool in suspected pediatric pulmonary TB. In comparison to a reference standard, the sensitivity and specificity of stool Xpert Ultra testing in children with presumptive TB are 67% and 99%, respectively.4 The sensitivity is higher (79%) …
Dhruv Gandhi, Viren Amesur, Minnie Bodhanwala, Ira Shah
Abstract Background Pediatric central nervous system tuberculosis (CNS-TB) accounts for 10% of all pediatric TB cases in India and carries the highest morbidity and mortality. However, data on pediatric drug resistant (DR) CNS-TB remains scarce. Regional data from Mumbai suggests…
Sun J, Fan L, Zhao Y, Wu H, Li R, et al.
…We retrospectively analyzed drug resistance testing data of pediatric TB patients between 2017 and 2021, and included 2976 clinically-diagnosed pediatric TB patients. We described the epidemiology of DR-TB and analyzed the trends of DR-TB incidence. The Kappa value was calculated…
Pecora F, Dal Canto G, Veronese P, Esposito S
… last few years. It has been estimated that about 3% of all pediatric TB is MDR, meaning about 30,000 cases each year. Although most children with MDR-TB can be successfully treated, up to five years ago effective treatment was associated with a high incidence of severe adverse e…
Gaurav Sharma, Bharti Malhotra, Paget John, Shipra Bhargava
…d to detect the incidence of tuberculous meningitis (TM) in pediatric patients using GenoType MTBDRplus, GenoType MTBDRsl, and Mycobacteria Growth Indicator Tube (MGIT). Additionally, it aimed to evaluate the utility of GeneXpert MTB/RIF assay in the detection of Mycobacterium tu…
Song WM, Li YF, Liu YX, Liu Y, Yu CB, et al.
…ntified 4,063 studies, of which 37 were included. Of 23,652 pediatric TB patients, the proportions of DR-TB, MDR-TB, mono-resistant TB, polydrug resistant TB, extensively drug-resistant TB were 13.59% (1,964/14,453), 3.72% (881/23,652), 6.07% (529/8,719), 1.61% (119/7,361), 0.44%…
Shah I, Poojari V, Meshram H
…NTCP, the use of DLM is approved in children 6 y and above. Pediatric MDR/XDR TB treatment outcome with newer anti-TB drugs and regimen is lacking. Children when treated with individualized regimens have improved survival.
E. A. Krushinskaya, Л. В. Панова, V. V. Bereznitskaya, E. S. Ovsyankinа, О. А. Пискунова
…to treatment with two-stage surgery and consultation from a pediatric cardiologist allowed completing the main course of TB treatment and achieving successful treatment outcome.
Majani Edward, Ameh Wisdom Owoicho
…lexities, particularly for difficult-to-diagnose forms like pediatric and extrapulmonary TB (including central nervous system TB), the alarming rise and spread of drug-resistant TB (MDR-TB and XDR-TB), the pervasive impact of social stigma on care-seeking and adherence, and the l…
Parissa Farnia, Ali Akbar Velayati
… is indicated as a part of combination therapy in adult and pediatric patients (≥5 years, weighing ≥15 kg) with pulmonary MDR-TB. BDQ has become central to MDR-TB therapy and is also a part of the shorter and oral regimen. Based on the result of a systematic review and a meta-ana…
Dhruv Gandhi, Shatakshi Garg, Sonal Patil, Dhruv Mamtora, Ira Shah
…etects resistance to multiple drugs, but its performance in pediatric TB remains understudied. The aim of this study is to evaluate the agreement between Xpert MTB/Rif or Ultra, Xpert MTB/XDR, LPAs, and 3-drug pDST for detecting antitubercular drug resistance in children.Table 1:…
E. S. Ovsyankinа, Л. В. Панова
…emotherapy and is an urgent problem at the present stage of pediatric phthisiology.
Patra J, Irving H, Maini P, Liang J, Patra A, et al.
…XDR- tuberculosis (TB) account for approximately a third of pediatric MDR-TB cases globally. Clinical management is challenging; recommendations are based on limited evidence. We assessed the clinical outcomes for children and adolescents treated for XDR-and pre-XDR-TB. We perfor…