Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Noorsuzana Mohd Shariff, Shamsul Azhar Shah, Fadzilah Kamaludin
…ients had a significant contribution to the transmission of drug-resistant tuberculosis in the community. However, little is known about the profile of foreign-born drug-resistant patients in Malaysia, and this has become the aims of this current study. Methods and materials: Thi…
Anderson K, Pietersen E, Dheda K, van der Heijden YF
Background Simplified drug-resistant tuberculosis (DR-TB) treatment outcome definitions, mostly centred around receipt of treatment and sputum culture status at 6 months after treatment initiation, have been proposed, but have not been widely evaluated in resource-limited setting…
A. A. Zhurilo, A. I. Barbova
The continued rise in the prevalence of multidrug-resistant and extensively drug-resistant tuberculosis in the era of human immunodeficiency virus infection poses a serious threat to effective tuberculosis control. Drug resistance in M. tuberculosis occurs due to lowfrequency spo…
Yunusbaeva M, Borodina L, Alekseev P, Davydov R, Yunusbaev U, et al.
…ountries, is characterized by one of the highest burdens of drug-resistant tuberculosis. Published data on the drug-resistant tuberculosis for these countries are limited, and it is not clear whether current treatment regimens remain effective against constantly evolving drug-res…
Durgadevi Ravi, Vishwanath kaliyaperumal, Bhuvaneswari Gunasekar, Shyamaladevi Babu
… health crisis, with millions of cases and deaths annually. Drug-resistant strains like multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB further complicate treatment. Conventional TB treatment, reliant on lengthy drug regimens, faces issues of non-compliance, dru…
Balaji Zacharia, Antony Roy
…the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug…
Yitagesu Habtu, Tesema Bereku, Girma Alemu, Ermias Abera
…iopia is one of among thirty high burden countries of multi-drug resistant tuberculosis (MDR-TB) in the regions of world health organization. Contextual evidence on the emergence of the disease is limited at a program level. </sec> <sec> <title>OBJECTIVE</title> The aim of the st…
Deepika Rai, Priyanka Padwal, Priyanka Purkayastha, Sarika Mehra
ABSTRACT Resistance to multiple drugs is one of the significant barriers in the treatment of tuberculosis (TB). Knowledge of mechanisms of resistance is important to design effective treatment strategies. While mutations in genes coding for drug targets are thought to be the prim…
Ogari CO, Nyamache AK, Nonoh J, Amukoye E
…as to determine the prevalence of mutations responsible for drug resistance in Mycobacterium tuberculosis among patients visiting selected health centers in Nairobi, Kenya. Methods The cross-sectional study involved 132 TB positive patients visiting Mbagathi and Chandaria hospita…
Kyla Sherwood, Shom Dasgupta-Tsinikas, David L Fuller
Abstract Background Prompt identification of drug-resistant tuberculosis (DR-TB) is crucial for the timely initiation of effective therapy, but phenotypic drug susceptibility testing (pDST) takes weeks to provide results. Advanced molecular drug susceptibility testing (mDST) allo…
Khaoula Balgouthi, Emel Eker, Manaf AlMatar, Osman Albarri, Işil Var
Anti-tuberculosis activity and resistance were recently refocused since clofazimine (CFZ) had a significant therapeutic benefit in treating multi-drug resistant tuberculosis (MDR-TB). We investigate the resistance of CFZ and genetic mutations in drug-resistant Mycobacterium tuber…
Nguyen QH, Contamin L, Nguyen TVA, Bañuls AL
At present, the successful transmission of drug-resistant Mycobacterium tuberculosis , including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, in human populations, threatens tuberculosis control worldwide. Differently from many other bacteria, M. tuberc…
Dirie AMH, S Çolakoğlu, Abdulle OM, Abdi BM, Osman MA, et al.
…ospital, Mogadishu, Banadir, Somalia; 2Manager of the Multi-Drug Resistant Center in Southern Somalia, Mogadishu, Banadir, Somalia; 3HIV Program manager, Ministry of Health, Somali Federal Government, Mogadishu, Banadir, Somalia; 4Infectious and Microbiology Department, Somalia M…
Yani Jane Sugiri, Rezki Tantular, Silvy Amalia Falyani, Uray Riki Arif Maulana
…evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission prevention. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB)…
Maladan Y, Krismawati H, Wahyuni T, Tanjung R, Awaludin K, et al.
…ll becomes a burden for many countries including Indonesia. Drug resistance is one of the problems in TB treatment. However, a development in the molecular field through Whole-genome sequencing (WGS) can be used as a solution in detecting mutations associated with TB- drugs. This…
Tang C, Wu L, Li M, Dai J, Shi Y, et al.
Drug-resistant tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), is one of the urgent clinical problems and public health challenges. Culture-based phenotypic drug susceptibility testing (pDST) is time-co…
Zhang X, Lam C, Martinez E, Sim E, Crighton T, et al.
…f Mycobacterium tuberculosis harboring mutations conferring resistance can become dominant populations during tuberculosis (TB) treatment, leading to treatment failure. Our understanding of drug-resistant within-host subpopulations and the frequency of resistance-conferring mutat…
Oyeniyi Muhammed, Israel Olukayode Popoola, Muhammed Mubashir B Uthman, Ebenezer Obi Daniel, Taiwo Popoola, et al.
… in regions like Nigeria. In this context, the emergence of drug-resistant strains of Mycobacterium tuberculosis poses an escalating challenge. This study aimed to assess awareness of anti-TB drug resistance among TB patients in Kwara State, Nigeria. Utilizing a descriptive cross…
Askar Zetov, Kulakhmed Erimbetov, Nargiza Parpieva, Bolat Zhetibayev, Abzal Malbaskanov
… a surgical approach in treatment of multi- and extensively drug-resistant tuberculosis.Design:The article described a retrospective analysis of surgical treatment of 246 multi- and extensively drug-resistant tuberculosis patients who were divided into 3 groups: 152 multi-drug-re…
Paulina M. Mejía‐Ponce, Elsy Janeth Ramos-González, Axel Alejandro Ramos-García, Edgar E. Lara‐Ramírez, Alma R. Soriano-Herrera, et al.
…es worldwide. New diagnostic tools and approaches to detect drug-resistance must be introduced by 2025 to achieve the End-TB Strategy goals set for 2030 by the WHO. Genomic epidemiology of TB has allowed the expansion of catalogs listing genetic signatures of Mtb drug-resistance.…
Venkata Giri Prasad Polu, Sreekanth Basireddy, Kota Neela Mani Kanta, Mithun Roy, Benson Wesly Buraga, et al.
The rise of pre-extensively drug-resistant (pre-XDR) and extensively drug-resistant (XDR) tuberculosis (TB) represents a serious threat to global health. This research investigates resistance patterns of Mycobacterium tuberculosis (MTB) clinical isolates to fluoroquinolones (FQs)…
Zhao,Jinyun, Mao,Weifang, Jin,Faxiang, Xu,Wenfang
…l zjy19871987@163.comObjective: This study aimed to analyze drug resistance patterns, mutation profiles in Mycobacterium tuberculosis isolates and clinical characteristics of tuberculosis patients in Shaoxing, Zhejiang, China.Methods: Clinical specimens and data from tuberculosis…
Álvaro Auñón, Santiago Gabardo, Carmen Álvaro, Ricardo de la Concha, Javier Sanado, et al.
…thetic joint infection (PJI), but the outcome impact of key resistance phenotypes is unclear. Methods: We retrospectively studied consecutive monomicrobial S. epidermidis PJIs treated at a tertiary hospital (2010–2024). PJI was defined according to 2018 ICM criteria. Success requ…
Giller Db, Stepan Saenko, A. N. Gerasimov, G. V. Shcherbakova, A. A. Popova, et al.
…e effectiveness of surgical treatment in patients with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Materials and methods : We examined immediate treatment outcomes of 1180 patients who underwent surgery for destructive MDRTB, pre-XDR-TB, and …
A Stoltz, R R Nathavitharana, E de Kock, V Ueckermann, P Jensen, et al.
**BACKGROUND:** Most drug-resistant tuberculosis occurs due to transmission of unsuspected or ineffectively treated drug-resistant tuberculosis. The duration of treatment to stop person-to-person spread of drug-resistant tuberculosis is uncertain. We evaluated the impact of novel…