Showing 176–200 of 200 documents
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Ding X, Du W, Liu Q, Tao L, Shao Y, et al.
…PPD, and EC tests. In the second stage, to evaluate whether BCG vaccination affected the efficacy of skin tests, the participants with three negative results in the first stage were randomly assigned to the BCG and placebo groups at a ratio of 2:1 and underwent three tests. The p…
Hernandez-Pando R, Shin SJ, Clark S, Casonato S, Becerril-Zambrano M, et al.
…he major threats to global human health. The only available vaccine ( Mycobacterium bovis BCG) protects children from disseminated forms of TB but does not effectively protect adults from the respiratory form of the disease, making the development of new and more-efficacious vacc…
Ahmed M, Farris E, Swanson RV, Das S, Yang Y, et al.
…o affect other sites (extrapulmonary TB). The only licensed vaccine Mycobacterium bovis bacillus Calmette-Guerin (BCG) protects infants and young children but exhibits variable efficacy in protecting against adult pulmonary TB. Poor compliance and prolonged treatment regimens ass…
Enriquez AB, Izzo A, Miller SM, Stewart EL, Mahon RN, et al.
…f death worldwide due to a single infectious disease agent. BCG, the only licensed vaccine against TB, offers limited protection against pulmonary disease in children and adults. TB vaccine research has recently been reinvigorated by new data suggesting alternative administration…
Sethi G, Varghese RP, Lakra AK, Nayak SS, Krishna R, et al.
…the situation more concerning. Currently, the only licensed vaccine BCG (Bacillus Calmette-Guérin) is ineffective in preventing adult pulmonary tuberculosis prophylaxis and latent tuberculosis re-activation. Therefore, there is a pressing need to find novel and safe vaccines that…
Schrager LK, Vekemens J, Drager N, Lewinsohn DM, Olesen OF
…imelines to control the spread of the disease require a new vaccine capable of preventing tuberculosis, particularly in adolescents and adults. The spread of strains resistant to multiple drugs adds additional urgency to the vaccine development effort yet attempts to develop new …
Cynthia Bin Eng Chee, David S.C. Hui
… continue to be important. The availability of pneumococcal vaccines and multiplex polymerase chain reactions (PCR) has led to a decreasing incidence of pneumococcal pneumonia and detection of more viral aetiologies in CAP. In recent years, rapid and automated molecular tests bas…
Lubyayi L, Mawa PA, Nabakooza G, Nakibuule M, Tushabe JV, et al.
Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization. Methods: We enrolled 132 LTBI-positive …
Watt J, Liu J, Liu J
…B and 1.45 million deaths in 2018. Bacille Calmette-Guérin (BCG) remains the only approved vaccine for Mycobacterium tuberculosis ( M. tb , causative agent of TB), however clinical studies have shown BCG has variable effectiveness ranging from 0-80% in adults. With 1.7 billion pe…
Jeyanathan M, Xing Z
…obal health concerns. There has been a lack of an effective vaccine strategy. The Bacillus Calmette-Guerin (BCG), the only licensed vaccine against TB, is not effective against adult pulmonary TB, the highly contagious form of TB. In the past two decades or so, many novel TB vacc…
Runlin Wang, Xiaochun Wang, Lingyun Kong, Qishan Sun, Jiagao Wu, et al.
…terium tuberculosis (M. tb). Bacillus Calmette-Guérin (BCG) is currently the only approved vaccine for TB prevention; however, its protective efficacy against tuberculosis in adults is limited. To overcome the limitations of BCG, recombinant plasmids were constructed and exp…
Scriba TJ, Netea MG, Ginsberg AM
…loyment of standard drug regimens, modern diagnostics and a vaccine (bacille Calmette Guerin, BCG), the global tuberculosis epidemic is inadequately controlled. Novel, effective vaccine(s) are a crucial element of the World Health Organization End TB Strategy. TB vaccine research…
Ferdous Ara Ahmed, Beatrice Onyinyechi Mkpa, Sadia Afroz, M. Naimul Islam Nakib, Md Nabiul Islam
… aims to investigate the trends of TB prevalence, treatment efficacy, and prevention efforts in a cohort of 300 TB cases in Dhaka. Methods: A cross-sectional study design was utilized to assess TB prevalence, treatment outcomes, and prevention efforts among 300 TB cases in Dhaka.…
Chugh S, Bahal RK, Dhiman R, Singh R
…he risk of TB is immunization with bacilli Calmette-Guerin (BCG). Although BCG has been widely used to protect against TB, reports show that BCG confers highly variable efficacy (0-80%) against adult pulmonary TB. Unwavering efforts have been made over the past 20 years to develo…
A. L. A. Leite, A. S. M. dos Santos, A. C. L. G. Silva, S. M. Arruda
… 10.6 million new cases in 2021. Bacillus Calmette-Guérrin (BCG) is the only licensed vaccine against TB, despite its variable efficacy (0-80%) against the pulmonary from of the disease in adults. Recent clinical trials indicate the importance of exploring diverse classes of anti…
Robyn M. Jong, Erik Van Dis, Xammy Nguyenla, Alexander Baltodano, Gabrielle Pastenkos, et al.
Abstract The only licensed vaccine for tuberculosis, Mycobacterium bovis Bacille Calmette-Guérin (BCG), is not reliably effective against adult pulmonary tuberculosis. A major hurdle to tuberculosis vaccine development is incomplete understanding of successful immunity against th…
Dongdong Zhang, Donghui Wang, Shuo Jiang, Yue Wan, Yukun Zhao, et al.
…at affects people worldwide. Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, has been shown to have highly variable protective efficacy in different populations and is ineffective at protecting adults. Therefore, the development of more effective TB vaccines is…
Li J, Zhao A, Tang J, Wang G, Shi Y, et al.
Bacillus Calmette-Guérin (BCG) has been in use for nearly 100 years and is the only licensed TB vaccine. While BCG provides protection against disseminated TB in infants, its protection against adult pulmonary tuberculosis (PTB) is variable. To achieve the ambitious goal of eradi…
Larson EC, Ellis-Connell AL, Rodgers MA, Gubernat AK, Gleim JL, et al.
…ficiency virus (HIV). Intra-dermal Bacille Calmette-Guérin (BCG) delivery is the only licensed vaccine against tuberculosis; however, it offers little protection from pulmonary tuberculosis in adults and is contraindicated in people living with HIV. Intravenous BCG confers protec…
Yang Y, Chen YZ, Xia T
…omplex (MTBC). For a century, the Bacillus Calmette-Guérin (BCG) vaccine has been the primary preventive measure against TB. While it effectively protects against extrapulmonary forms of pediatric TB, it lacks consistent efficacy in providing protection against pulmonary TB in ad…
Bashar Haruna Gulumbe, Aminu Shehu
…is correspondence underlines the critical role of advancing vaccine research. Historically, the BCG vaccine, developed over a century ago, has been the cornerstone of TB prevention. However, its efficacy is limited, particularly in adults and against pulmonary TB, the most common…
Bull NC, Kaveh DA, Garcia-Pelayo MC, Stylianou E, McShane H, et al.
…use of human mortality from an infectious disease. The only vaccine currently available, bacille Calmette-Guérin (BCG), demonstrates some protection against disseminated disease in childhood but very variable efficacy against pulmonary disease in adults. A greater understanding o…
Abil OZ, Liu S, Yeh YW, Wu Y, Sen Chaudhuri A, et al.
…the top three causes of death. Currently, the only licensed vaccine against TB is the bacillus Calmette-Guerin (BCG), which lacks efficacy in preventing and controlling pulmonary TB in adults. We aimed to evaluate a nasal TB vaccine formulation composed of the Mtb-specific vaccin…
Zehui Lei, Jing Wang, Cui Hua Liu
… remains a leading burden on global health and the economy. Vaccines represent the most economically effective approach to preventing and controlling infectious diseases. Currently, Bacillus Calmette–Guérin (BCG) is the only available vaccine for TB, which protects infants and yo…
Qian C, Fan X, Wang R, Cao B, Yu J, et al.
…ad use of the Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccine, the primary factor for the TB pandemic and deaths is adult TB, which mainly result from endogenous reactivation of latent Mycobacterium tuberculosis (MTB) infection. Improved new TB vaccines with eligible s…