Showing 151–175 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Muhammad Rifqy Alvy Widodo, Ida Srisurani Wiji Astuti, Inke Kusumastuti, Angga Mardro Raharjo, Supangat Supangat, et al.
… comparison between the administration of individual MDR-TB regimens and short-term regimens concerning anxiety levels in MDR-TB patients at Dr. Soebandi Regional General Hospital, Jember. Methods: This was an analytical observational study with a cross-sectional design. It was c…
Yohanes Widjaja, Khairuddin Djawad, Saffruddin Amin, Widyawati Djamaluddin, Dirmawati Kadir, et al.
Abstract Introduction . Leprosy is a disease that predominantly affects the skin and peripheral nerves, resulting in neuropathy and associated long-term consequences, including deformities and disabilities. According to the WHO classification, there are two categories of leprosy,…
Yu. I. Feshchenko, N.А. Lytvynenko, M.V. Pohrebna, Yu.О. Senko, Anastasiia Lafeta, et al.
Objective — to study the programmatic results of the efficacy and tolerability of the standard combination BPaL regimen for patients with multidrug-resistant tuberculosis failures and pre-XDR-TB. Materials and methods. Treatment of patients with BPaL regimen took place within th…
Stephanie Palacios, Glenford Refre, Patricio Palmes, Ma. Cecilia Momville
…abases, comparing the 4-month and 6-month anti-TB treatment regimens. RCTs that were published in the English language from 2017-2022 that used drug susceptible TB adult patients were included in the final meta-analysis. We compared the efficacy and safety of the two regimens usi…
Jyoti Bajpai, Darshan Kumar Bajaj, Sandeep Kumar, Rashmi Kushwaha, Surya Kant, et al.
…fication test)&LPA(Line Probe Assay)and availability of regimens with duration of 9-11months in contrast to previous lengthy regimens things have become better. Present study was undertaken to study microbiological conversion and adverse effect profile of shorter regimen <b>M…
Musfardi Rustam, Ratna Djuwita, Sudarto Ronoatmodjo, Erlina Burhan, Evi Martha, et al.
…ster on the 272 th day. The risk of T2DM group with the new regimens in the treatment of DR-TB was 10.66 times (95% CI 3.23-35.12). Whereas, the treatment on NonT2DM group with old regimen with marital status that was controlled showed a significant statistic value with value p&l…
Van Deun A, Decroo T, Kya Jai Maug A, Hossain MA, Gumusboga M, et al.
…two months), but had little impact on rifampicin-throughout regimens: (6 months, new cases; 3.8%; OR 0.8, 95%CI:0.3,2.8; 8 months, retreatment cases: 7.3%, OR 1.8; 95%CI:1.3,2.6). Rr was missed in 7.6% of randomly selected "Hr" strains. Acquired Rr was frequent among recurrences …
Song L, Zhang Y, Sun F, Lan Y, Tong J, et al.
…atment have led to concerns about hepatotoxicity in shorter regimens. We evaluated hepatotoxicity in two novel regimens against the standard shorter regimen recommended by the World Health Organization (WHO). Methods Participants from the TB-TRUST and TB-TRUST plus trials were as…
Mojisola Clara Hosu, Lindiwe Modest Faye, Teke Apalata
…time ranged from 29 to 59 days. Patients on short treatment regimens converted significantly faster than those on long regimens (= 7.55 × 10), with 90% of short-regimen patients achieving favorable outcomes compared to 52% in the long regimen group (= 0.0000040). Spearman co…
Ardhianto D, Suharjono, Soedarsono, Fatmawati U
…ion. The aim was to study the differences in the use of BDQ regimens to the lengthening of the QTc interval and to study risk factors (diabetes, hypokalemia, sex, BMI, and age) in BDQ regimen. Methods This study was an observational retrospective study with a total sampling metho…
Arinaminpathy N, Gomez GB, Sachdeva KS, Rao R, Parmar M, et al.
…re is increasing interest in future, highly-potent 'pan-TB' regimens against tuberculosis (TB), that may be equally effective in both drug-susceptible and rifampicin-resistant (RR) forms of TB. Taking the example of India, the country with the world's largest burden of TB, we sho…
Jorge Torresi, Ana Angélica Bulcão Portela Lindoso
…lable drugs. The recent implementation of bedaquiline-based regimens represents an advance in combating this condition, although few studies have evaluated the public health impact of their implementation. The present study aimed to evaluate the impacts of implementing oral regim…
Van Deun A, Decroo T, Piubello A, de Jong BC, Lynen L, et al.
…th Organization guidelines for the formulation of treatment regimens for multidrug-resistant tuberculosis (MDR-TB) pay too little attention to the microbiological activity of anti-tuberculosis drugs. Here, we draw lessons from the pioneering work done on shorter MDR-TB treatment …
Gauri Goswami, Pradeep Nirala, Rajeev Tandon, Pulkit Kalra, Mohammed Tariq, et al.
…omorbidities often necessitate alternative non-standardized regimens. Objective The aim of the study was to identify and evaluate the use, rationale, and outcome of non-standardized ATT regimens in patients with drug-sensitive tuberculosis. Method Our prospective observational st…
Rais M, Abdelaal H, Reese VA, Ferede D, Larsen SE, et al.
…me/boost regimen. More significantly, among all the vaccine regimens tested only repRNA-ID91/ID91+GLA-SE induced IFN-γ and TNF-secreting CD8 + T cells. Furthermore, the repRNA-ID91/ID91+GLA-SE vaccine strategy elicited high systemic proinflammatory cytokine responses and induced …
Rodriguez CA, Lodi S, Horsburgh CR, Mitnick CD, Bastard M, et al.
Clarity about the role of delamanid in longer regimens for multidrug-resistant TB is needed after discordant Phase IIb and Phase III randomized controlled trial results. The Phase IIb trial found that the addition of delamanid to a background regimen hastened culture conversion; …
Avaliani T, Sereda Y, Davtyan H, Tukvadze N, Togonidze T, et al.
Tuberculosis treatment is challenging, especially among people with drug-resistant forms of tuberculosis. The introduction of fully oral modified short treatment regimen has a great potential to shorten duration of treatment, improve safety and ultimately increase treatment succe…
Zhang Y, Zhu H, Fu L, Wang B, Guo S, et al.
…mine in in vitro and animal experiments. To identify potent regimens containing TBI-166 in TB chemotherapy, TBI-166 was assessed for pharmacological interactions in vitro and in vivo with several anti-TB drugs, including isoniazid (INH), rifampin (RFP), bedaquiline (BDQ), pretoma…
Yue-E Wu, Jing Cao, Li Wang, Ying-Ji Wei, Hui-Xin Liu, et al.
**BACKGROUND:** Spinal tuberculosis is the most common form of osteoarticular infection, with recommended anti-tuberculosis treatment durations typically being long (9-18 months), even for mild cases, increasing the risks of drug resistance, toxicity, and poor patient adhere…
Gualano G, Musso M, Mencarini P, Mosti S, Cerva C, et al.
… of MDR-TB has been revolutionized by all oral anti-TB drug regimens that are likely to improve adherence and treatment outcomes. These regimes include bedaquiline (B), pretomanid (P), and linezolid (L) (BPaL), and moxifloxacin if resistance to fluoroquinolones is not detected (B…
Ur Rehman O, Fatima E, Ali A, Akram U, Nashwan A, et al.
…ire treatment with newer drugs. Bedaquiline based treatment regimens have been used in patients who are diagnosed with drug resistant tuberculosis. The aim of this study is to assess the efficacy and safety profile of bedaquiline-based treatment regimens using a systematic review…
Modongo C, Wang Q, Dima M, Matsiri O, Kgwaadira B, et al.
… patients concomitantly receiving rifampicin- and DTG-based regimens under programmatic conditions in Botswana. The outcomes of interest were successful TB treatment and viral load suppression. We used multivariable logistic models to determine predictors for each outcome of inte…
Phillips PPJ, Van Deun A, Ahmed S, Goodall RL, Meredith SK, et al.
…to 84.2% across five alternative outcomes. However, between-regimens results did not exceed 1.3% in favor of the long regimen (95% CI upper bound 10.1%), similar to the primary efficacy results from the trial. Considering only Definite or Probable FoR events, there was weak evide…
Anaam MS, Alrasheedy AA
…rd 6-month regimen was lower than that with the previous TB regimens. However, more efforts are needed to decrease TB recurrence rates further and achieve a durable cure for TB. In addition, healthcare professionals and TB control programs should consider potential risk factors o…
Shah R, Khakhkhar T, Modi B
…lysis, we compared the efficacy and safety of different TPT regimens. We searched PubMed, Google Scholar, and medrxiv.org with search terms Tuberculosis Preventive Treatment, TPT, efficacy, safety, and drug regimens for TPT and all RCT, irrespective of age, setting, or co-morbidi…