Showing 151–175 of 200 documents
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Zahra Hasan, Sadia Shakoor, Rumina Hasan
…ountries (LMICs) with a high burden of infectious diseases. Tuberculosis (TB), a major source of morbidity and mortality worldwide, was further exacerbated by the COVID-19 pandemic, resulting in up to 1.5 million deaths in 2020 [[1]WHOGlobal tuberculosis report 2021. World Health…
Alshrouf MA, Elifranji ZO, Halayqeh S, Al-Saber M, Karam AM
Introduction Tuberculosis (TB) is one of the most prevalent infectious diseases globally, often presenting with nonspecific symptoms that can obscure diagnosis, especially when it manifests in uncommon sites such as osteoarticular tuberculosis (OA-TB). Case presentation We report…
Stefani Candra Firmanti, Rina Triasih, Tri Wibawa, Sofia Mubarika Haryana
BACKGROUND: The diagnosis of tuberculosis (TB) in children is challenging by the absence of a practical gold standard. Interferon (IFN)-ginducible protein 10 (IP-10) is a chemokine that may serve as the leading candidate marker in child TB diagnosis. The aim of this study is to a…
Damla Sel Coban, Hıncal Özbakır, Berna Avci Yavuz, Berna Kahraman Çetin, Özlem Erdoğan, et al.
To the Editors: Tuberculosis (TB) remains a significant public health concern in children, particularly in endemic regions. However, diagnosis can be challenging due to other respiratory infections that present with similar clinical and radiological features. Here, we report the …
М. С. Опанасенко, O.V. Tereshkovich, S. М. Shalahai, L. І. Levanda, T.V. Kirillova
Pediatric surgeons often to have different indications for the diagnosis and treatment of pathology of the thoracic cavity. Often, only invasive techniques, such as a biopsy, can help diagnose and determine further treatment. One of the reasons for performing thoracic operations …
Sun L, Qi X, Liu F, Wu X, Yin Q, et al.
Objectives Xpert Mycobacterium tuberculosis and rifampicin (MTB/RIF) Ultra assay has increasingly been used in adult tuberculosis diagnosis, but data relating to its diagnostic accuracy in children are lacking. Because a qualified sputum specimen is difficult to obtain in childre…
The Lancet Microbe
When approximately 40% of people who develop tuberculosis (4·2 million of an estimated 10·6 million people, in 2021, according to WHO) are not diagnosed, how can the widespread use of sputum smear microscopy for initial diagnosis—a method developed over a century ago—still be jus…
Brilliant Deva Aspada, Komang Agung Irianto Suryaningrat, Pudji Lestari, Primadenny Ariesa Airlangga
Spinal Tuberculosis is a secondary tuberculosis due to hematogenous spread from the primary infection site (lungs) caused by the bacteria Mycobacterium tuberculosis and is chronic-destructive in nature which attacks the spine. Manifestations in the form of deformity can also be c…
Ngadaya E, Kimaro G, Sandi E, Mnyambwa NP, Wilfred A, et al.
Background Diagnosis of pulmonary tuberculosis remains grim, especially in resource-limited settings. Low quality of sputum, particularly among seriously ill, HIV/AIDS, and pediatric patients might result in missing the diagnosis. This study evaluated the performance of GeneXpert…
Meredith B Brooks, Giordano Sosa Soto, Jeffrey I Campbell, Farhana Amanullah, Tapash Roy, et al.
Pediatric extrapulmonary tuberculosis (EPTB) remains under-recognized due to biological, diagnostic, and systemic barriers. This Perspective outlines pragmatic, multilevel strategies-spanning frontline clinics to national systems-to strengthen diagnosis, reporting, and visibility…
Movahedi Z, Mahmoudi S, Banar M, Pourakbari B, Aziz-Ahari A, et al.
Introduction Reductions in global tuberculosis incidence are considered as one of the End TB Strategy goal. The diagnosis of tuberculosis (TB) in children is challenging due to insufficient specimen material and the scarcity of bacilli in specimens. The purpose of this study was …
Nicol MP, Wood RC, Workman L, Prins M, Whitman C, et al.
Microbiological diagnosis of pediatric pulmonary tuberculosis (TB) is challenging due to the difficulty of collecting and testing sputum from children. We investigated whether easily-obtained oral swab samples are useful alternatives or supplements to sputum. Oral swabs and induc…
Daniel Edisha Garba, Uju Marie-Esther Dibua, Chiamaka Ukamaka Oka, Yvonne Ogechukwu Ozoadibe, Friday Attah, et al.
Urogenital tuberculosis (UGTB) is a common extrapulmonary manifestation of TB, but its diagnosis remains challenging due to nonspecific symptoms and limited diagnostic tools. Despite its significant impact on global health, it remains incompletely understood and often overlooked.…
Cai Q, Shen X, Li H, Yao C, Sun N, et al.
Background Mycobacterium tuberculosis (Mtb)-specific perforin were significantly increased in patients with tuberculosis. This study aims to evaluate the diagnosis value of Mtb-specific perforin in pediatric patients with tuberculosis. Methods Diagnostic performance of perforin l…
Khondker Qamruzzaman, Syed Ahsan Tauhid, Dr. Md. Ashiqur Rahman, Sk Sadek Ali, Dr. Md. Nahidul Islam, et al.
Background: Pulmonary tuberculosis (PTB) remains a significant health issue in children. Early and accurate diagnosis is critical but challenging, The GeneXpert test, a rapid and accurate molecular diagnostic tool, has improved TB detection by identifying Mycobacterium tuberculos…
Made Winatra Satya Putra, Made Agus Maharjana, I Ketut Siki Kawiyana
Background: Tuberculosis of the bone is a serious problem in developing countries, extra-pulmonary tuberculosis is more common among children. The characteristics of tuberculosis osteomyelitis in children are different. Therefore, the disease is often neglected or diagnosis is de…
Claudia Ozela El- Husny, Ângela Maria Rodrigues Ferreira, Jamilie Suelen dos Prazeres Campos, Kamila Nancy Gonçalves da Gama, Iací Proença Palmeira, et al.
Introduction: Tuberculosis control tools are a challenge to primary health care, due to the delay of people from the appearance of the first symptoms to the search for the first health-care service, and health-care services leading to difficulties and delay in establishing the di…
Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, et al.
Background The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found u…
Deepmala Pandey, Ankur Yadav
Background: Body fluids are commonly used for diagnosis as sputum is not reliable in children. Hence it is essential to study efficacy of body fluids in comparison to GeneXpert which is a new diagnostic modality. Objectives of this study was to incidence of rifampicin resistance,…
Muhammad Ali Shodikin, Desie Dwi Wisudanti, Annisa Nadhifa Witanto
Background: Tuberculosis (TB) remains a major public health problem globally. TB in children is an important component in TB control. The diagnosis of TB in children until now is still challenging, underdiagnosis often occurs in primary health facilities in Indonesia. This study …
E. P. Еremenko, Е. А. Бородулина, I. A. Sergeeva, D.А. Kudlаy, B. E. Borodulin
…ests (Mantoux test with 2 TU PPD-L and diaskintest) for the diagnosis of tuberculosis infection, in vitro tests are used. One of these tests is T-SPOT.TB being more widely used in recent years. The objective : to evaluate the effectiveness of T-SPOT.TB test for early detection of…
Singhal R, Dayal R, Bhatnagar S, Nayak M, Yadav N, et al.
…d as compared to CBNAAT in gastric aspirate (GA) samples in pediatric tuberculosis (TB). Methods This cross-sectional study was performed at Department of Pediatrics of a tertiary care hospital. Children aged 0-18 y diagnosed as presumptive tuberculosis were consecutively enrolle…
Anastasia Y. Starshinova, И. Ф. Довгалюк, Ulia Ovchinnikova, Анна Старшинова, P. K. Yаblonskiy
<b>Introduction:</b> Early diagnosis of TB infection in children is complicated due to poor clinical signs, minor X-ray abnormalities, and absence of bacterial excression. Potential of Mantuox 2 TE test in population with common BCG vaccination is limited due to its low diagnosti…
Xiaoxia Wang, Shaomei Huang, Hua Chen
… clinical and Imaging characteristics between children with pediatric pulmonary tuberculosis (PTB) and children with pneumonia who were initially suspected of PTB, and to explore valuable indicators for differential diagnosis. Methods This retrospective study enrolled pediatric i…
Farina E, D'Amore C, Lancella L, Boccuzzi E, Ciofi Degli Atti ML, et al.
Background Intercepting earlier suspected TB (Tuberculosis) cases clinically is necessary to reduce TB incidence, so we described signs and symptoms of retrospective cases of pulmonary TB and tried to evaluate which could be early warning signs. Methods We conducted a retrospecti…