Showing 151–175 of 200 documents
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Desai U, Joshi JM
Background Drug-resistant tuberculosis (DR-TB) is a global problem with only 52% reported cure rate. Extrapulmonary (EP) DR-TB poses a formidable diagnostic, therapeutic challenge. We aimed to study their clinical profile and treatment outcomes under the programmatic setting. Mat…
V Bajiya, C R Choudhary, G Purohit, A Kuwal, A Mohanty
<b>Background:</b> Drug resistant tuberculosis is a serious public health problem in India. Due to inappropriate use, resistance to FQs has increased, which is a major threat to control TB worldwide. FQ resistance is caused by mutation in gyrA and gyrB genes of Mycobacterium tube…
Jiandong Yang, Pengwei Lou, Weisheng Zhang, Yanggui Chen, Yaoqin Lu, et al.
…ate the epidemic status and distribution characteristics of drug-resistantin Urumqi. From January 2019 to July 2024, all sputum culture-positivestrains were collected in Urumqi. Using the traditional solid-state proportion method for drug-sensitivity testing, we determined the re…
Rêgo AM, Alves da Silva D, Ferreira NV, de Pina LC, Evaristo JAM, et al.
…ading cause of death. Mycobacterium tuberculosis antibiotic resistance is becoming increasingly common and disease control is challenging. Conventional drug susceptibility testing takes weeks to produce results, and treatment is often initiated empirically. Therefore, new methods…
Shraddha Dalvi, Poulami Biswas, Shatabdi Bhagat, Nilma Hirani
…ng cause of death from a single infectious agent worldwide. Drug-resistant TB (DR-TB) poses a major challenge. Bedaquiline (BDQ) is central to multidrug resistant tuberculosis/extensively drug-resistant TB (MDR/XDR-TB) treatment, yet emerging resistance prompted this study to ass…
Jalil Kardan-Yamchi, Hossein Kazemian, Arash Ghodousi, Daniela María Cirillo, Masoumeh Douraghi, et al.
Aims and objectives: Treatment of patients with drug-resistant tuberculosis is time-consuming and requires expensive drugs with more toxicity. Proper and timely identification of drug-resistant genotypes and determining the minimum inhibitory concentrations (MICs) alongside with …
Wang G, Jiang G, Jing W, Zong Z, Yu X, et al.
The drug resistance prevalence data facilitates selection of the initial drug for treating multidrug-resistant tuberculosis (MDR-TB). The aim of this study was to investigate the prevalence and molecular characterization of seven additional types of drug resistances among MDR-TB …
Noorizhab MNF, Zainal Abidin N, Teh LK, Tang TH, Onyejepu N, et al.
Multidrug-resistant (MDR) or extensively drug-resistant (XDR) Tuberculosis (TB) is a major challenge to global TB control. Therefore, accurate tracing of in-country MDR-TB transmission are crucial for the development of optimal TB management strategies. This study aimed to invest…
Miiro E, Olum R, Baluku JB
Background Drug-resistant tuberculosis (DR-TB) is a threat to tuberculosis (TB) control. Extra-pulmonary forms of DR-TB (DR-epTB) are not well characterized. This review summarizes the clinical features, resistance patterns and treatment outcomes of DR-epTB. Methods We searched E…
Okumu A, Orwa J, Sitati R, Omondi I, Odhiambo B, et al.
Multidrug-resistant tuberculosis (MDR-TB) is caused by M. tuberculosis ( Mtb ) with resistance to the first-line anti-TB medicines isoniazid (INH) and rifampicin (RIF). In Western Kenya, there is reported low prevalence of drug resistant strains among HIV tuberculosis patients, c…
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
Wang Z, Sun R, Mu C, Wang C, Zhao H, et al.
…cular characteristics of fluoroquinolone-resistant and multidrug-resistant M. tuberculosis strains using whole-genome sequencing to predict drug resistance in M. tuberculosis in Tianjin, China, which has not been established previously. Methods Twenty-one fluoroquinolone-resistan…
Tawsifur Rahman, Amith Khandakar, Ashiqur Rahman, Susu M. Zughaier, Muna Al Maslamani, et al.
… and expensive treatments. Moreover, due to the increase of drug-resistant tuberculosis, the disease becomes more challenging in recent years. In this work, a novel deep learning-based framework is proposed to reliably and automatically distinguish TB, non-TB (other lung infectio…
Li Q, Zhao G, Wu L, Lu M, Liu W, et al.
Background To evaluate prevalence and patterns of drug resistance among pulmonary tuberculosis (TB) patients in Hangzhou City, China. Methods Sputum samples of smear positive TB patients enrolled in 2011 and 2015 were collected and tested for drug susceptibility, and demographic …
Rana HK, Singh AK, Kumar R, Pandey AK
…culosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains need longer and more expensive treatment with many medications resulting in more adverse effects and decreased chances of treatm…
Hameed S, Ahmad SR, Rahman MAU, Nazir H, Ullah I
Objectives Drug-resistant tuberculosis (DR-TB) is a major challenge to national TB control programmes in developing countries. In the Pakistan province of Punjab, the extent and development of DR-TB is not well known. The current study was therefore conducted to assess the incide…
Pan Y, Yu Y, Lu J, Yi Y, Dou X, et al.
Purpose The emergence of drug-resistant tuberculosis (DR-TB) represents a threat to the control of tuberculosis. This study aimed to estimate the patterns and trends of DR-TB in patients with suspected DR-TB. In addition, risk factors for multidrug-resistant tuberculosis (MDR-TB)…
Ruesen C, Riza AL, Florescu A, Chaidir L, Editoiu C, et al.
Mycobacterium tuberculosis drug resistance poses a major threat to tuberculosis control. Current phenotypic tests for drug susceptibility are time-consuming, technically complex, and expensive. Whole genome sequencing is a promising alternative, though the impact of different dru…
Manita Yimcharoen, Sukanya Saikaew, Usanee Wattananandkul, Ponrut Phunpae, Sorasak Intorasoot, et al.
…mains a global health concern because of the development of drug resistance. The adaptability of MTB in response to a variety of environmental stresses is a crucial strategy that supports their survival and evades host defense mechanisms. Stress regulates gene expression, particu…
Ifrah Amjad, Saba Riaz
…rganisms. Microorganisms have noteworthy amplitude to offer resistance to antimicrobial agents and becoming an awful public health plight. The rising probability of infections is attributed to the ability of microbes conferring drug resistance. Drug resistance is a horrible capac…
Callistus A. Akinleye, Adekola O. Adekunle, A. Onabule, Olugbenga Adekunle Olowe, Olusoji Daniel
… tuberculosis has left everlasting scars on people’s lives. Drug-resistant tuberculosis is becoming an increasingly serious hazard to public health. With over 240,000 fatalities due to drug-resistant tuberculosis (DR-TB) worldwide, and Nigeria is one of the 14 nations with a sign…
Vinayak Talwar, Abhishek Sadasivan
…e global TB elimination without TB elimination in SEAR, and drug resistance is a significant obstacle to the elimination of TB.[4] Drug-resistant TB is brought on by either the spread of Mycobacterium tuberculosis strains that are already resistant or by the inadequate treatment …
Mandira Varma‐Basil
Aims and objectives: Multidrug resistant TB (MDR-TB) and extensively drug resistant (XDR) are responsible for significant obstruction to global control of tuberculosis (TB). Drug resistance in Mycobacterium tuberculosis mainly occurs through chromosomal mutations in genes encodin…
Pedro Gomes, Paulo Paixão, Fernando Maltez, Laura Brum, Jody E Phelan, et al.
…tuberculosis (TB) in Western Europe and, historically, multidrug-resistant (MDR) cases have been strongly associated withstrains pertaining to the endemic Q1 and Lisboa3 clades. Notwithstanding, the contribution of drug resistance-associated allelic configurations in these clades…
Parissa Farnia, Ali Akbar Velayati
With worldwide increases of rifampicin resistance, the World Health Organization (WHO) comes with a new definition of pre-extensively drug-resistant tuberculosis (XDR-TB) and XDR-TB. New definitions for pre-XDR and XDR-TB helped to define more precisely groups of TB patients who …