Showing 126–150 of 200 documents
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Trương Thiên Phú, Thuy Le, Viet Tran, Tung Thanh Phan
…ground: Tuberculosis (TB) still threatens human beings when drug-resistant tuberculosis (DR-TB), such as rifampicin-resistant TB, isoniazid-resistant TB, multidrug-resistant TB (MDR-TB), pre-extensively drug-resistant TB, and extensively drug-resistant TB increases continuously. …
Anila Jaleel, Farouk Qamar Malik, Imran Ali Zaidi, Sana Hafeez, Kiran Namoos
…se which is approximately 270 per 100,000. The emergence of drug resistant MTB poses a serious threat to the ongoing efforts to control the disease epidemic. Drug resistance to the first line drugs such as Isoniazid (INH) and Rifampicin (RIF) needs to be investigated. In this res…
Yiwang Chen, Howard Takiff, Qian Gao
…g (WGS) has shown great potential in the rapid diagnosis of drug-resistant tuberculosis;1Finci I Albertini A Merker M et al.Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multice…
LaFreniere M, Hussain H, Vachon J
Background Drug-resistant tuberculosis (TB) is a global public health issue. To monitor this in Canada, surveillance systems have been in place for the last 20 years. Objective To describe drug resistance patterns among TB isolates in Canada in 2017 by type of resistance as well …
Naila Samad, Ghulam Mustafa Wardak, Fakhra Batool, Hadeel Ahmed Kenoosh, Nnamdi C. Opara, et al.
Background. Pakistan is high burden drug resistant tuberculosis (DR-TB) country. For devising a treatment regimen and optimizing empirical drug therapy, the local epidemiology and drug resistance patterns are needed to be considered. Objectives. To evaluate the drug resistance pa…
Liu L, Zhao X, Wu X, Li S, Liu B, et al.
Background The emergence of antimicrobial resistance against Mycobacterium tuberculosis (M. tuberculosis) has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug…
Sarwer MI, Khan MT, Khurshid S
Introduction Phenotypic drug susceptibility testing is the most common approach to assess drug-resistant isolates; however, molecular methods of drug susceptibility testing are fast, accurate hence, offer less time for transmission during the diagnosis period. As data on the mole…
Zeng X, Kwok JS, Yang KY, Leung KS, Shi M, et al.
Background Drug resistance in Mycobacterium tuberculosis (MTB) is one of the major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain all of the cases of resistance and little research has focused on the relationship between insertions / deletions …
Siddharth G. Chatterjee, Arvind Pandey
Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. …
Prabha Desikan, Aseem Rangnekar, Nikita Panwalkar, Ram Prakash Punde, Sridhar Anand
Detection and treatment of drug resistance in extrapulmonary tuberculosis (EPTB) is a major challenge worldwide. Drug resistance in EPTB has not been studied extensively. However, patients with drug-resistant EPTB have been reported to have poor outcomes[1]. Rifampicin and isonia…
Monika, Rakesh Yadav
…berculosis and the risk has worsened with the appearance of drug resistance, in particular multi drug resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). Antimicrobial resistance (AMR), is one of the most dominant health hazard that has emerged in the 21st century. …
Maeda T, Kawada M, Sakata N, Kotani H, Furusawa C
Drug-resistant tuberculosis (TB) is a growing public health problem. There is an urgent need for information regarding cross-resistance and collateral sensitivity relationships among drugs and the genetic determinants of anti-TB drug resistance for developing strategies to suppre…
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, et al.
…easing burden of tuberculosis is mainly caused due to multi drug-resistance. The failure of conventional treatment has been observed in large number of cases. Drugs that are used to treat extensively drug-resistant tuberculosis are expensive, have limited efficacy, and have more …
Dhruv Gandhi, Shatakshi Garg, Sonal Patil, Dhruv Mamtora, Ira Shah
…olved from conventional methods like culture and phenotypic drug-sensitivity testing (pDST) to rapid molecular assays such as line probe assays (LPA), Xpert MTB/Rif, Xpert Ultra, and Xpert MTB/XDR. While LPAs are highly sensitive and specific, they require specialized infrastruct…
Nimmo C, Millard J, Faulkner V, Monteserin J, Pugh H, et al.
Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice. Compared to other bacteria, it has a well conserved genome due to its role as an obligate human pathogen that has …
Nduagu Samuel Uchechukwu, ONYEAGWARA Ngozi Carol, Ogisi Festus Oritsemajemite, MBATA Godwin Chukwuemeka
…challenge facing the global efforts against tuberculosis is drug-resistance, which necessitates the use of aminoglycoside-based second line drugs that are known to have ototoxic potentials. Hearing impairment can be a source of social distress, professional disability and in some…
Dipali Maganbhai Gavali, Binita Aring, Hiral Gadhavi, Akhlakahemad Nathamehta, Abhishek B Dave, et al.
…R-TB who had never been previously treated with second-line drugs. A prospective study was conducted in Culture and Drug susceptibility testing laboratory, Jamnagar and its associated Drug-Resistant Tuberculosis (DR-TB) centre. Materials and Methods: Baseline second-line liquid c…
Trigos AS, Goudey BW, Bedő J, Conway TC, Faux NG, et al.
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as "collateral sensitivity." This underexplored phenomenon opens new therapeutic possibilities for patients infected with pathogens unresponsive to classical treatments. Intrinsi…
Eoh H, Liu R, Lim J, Lee JJ, Sell P
…r non-replicating and lacking a stably heritable antibiotic resistance, termed drug tolerance). The formation of drug-tolerant Mtb persisters is associated with TB treatment failure and is thought to be an adaptive strategy for eventual development of permanent genetic mutation-m…
Utpat KV, Rajpurohit R, Desai U
Background Drug-resistant tuberculosis (DR-TB) is the most exigent and calamitous challenge encountered in treatment of TB. Extra pulmonary (EP) DR-TB poses a complex diagnostic and therapeutic challenge owing to myriad of presentations and paucibacillary nature. Data available o…
Aarav Sinha, Jothsna Kethar, Dr.Rajagopal Appavu
Drug-resistant tuberculosis (TB) poses a significant global health challenge, affecting millions worldwide. Annually, around half a million individuals develop drug-resistant TB, underscoring the urgency of addressing this issue. Treating drug-resistant TB is complex and lengthy,…
Tao NN, Li YF, Song WM, Liu JY, Zhang QY, et al.
…ve This study was designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and the association between comorbidity and drug resistance among retreated pulmonary tuberculosis (PTB). Design A retrospective study was conducted among all the 36 monitoring sites i…
Singh V, Chibale K, Chibale K
" Drug resistance is an unavoidable consequence of the use of drugs; however, the emergence of multi-drug resistance can be managed by accurate diagnosis and tailor-made regimens. "Antimicrobial resistance (AMR), is one of the most paramount health perils that has emerged in the …
Anil Regmi, Bishwa Bandhu Niraula, Abdus Sami, Vijay Kumar Jain, Gayatri Vishwakarma, et al.
Multidrug-resistant (MDR), pre-extensively drug-resistant (pre-XDR), and extensively drug-resistant (XDR) strains are associated with delayed diagnosis, protracted therapy, and increased morbidity. This article aims to systematically review the clinical spectrum, diagnostic strat…
Robin Varughese John, Hafiz Deshmukh, Sunil Jadhav, Ashish Deshmukh, Shivprasad Kasat, et al.
OBJECTIVE: To study the sensitivity and resistance pattern of multi-drug resistant tuberculosis patients at a tertiary care centre. METHODS: Retrospective study will be conducted at tertiary care centre in Aurangabad from which data of patients will be collected who have register…