Showing 101–125 of 200 documents
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Hu Y, Zheng X, Davies Forsman L, Ning Z, Chen C, et al.
Objectives Little is known about how additional second-line drug resistance emerges during multidrug-resistant tuberculosis (MDR-TB) treatment. The present study aimed to investigate the influence of microevolution, exogenous reinfection and mixed infection on second-line drug re…
Natalie E. Nieuwenhuizen, Lei Ji
The standard treatment regime for drug-sensitive TB is two months of therapy with rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol (EMB), followed by four months treatment with RIF and INH (2) Infection with Mtb strains resistant to RIF and INH is termed mult…
Sahjid Mukhida, Chanda Vyawahare
…ng are not in common people regarding various categories of drug-resistant TB (DRTB).[2] They don’t have awareness and differentiation about mono-resistant, multidrug-resistant (MDR), poly-drug-resistant (pDR), pre-extensive drug resistance (Pre-XDR), extensive drug resistance (X…
Fizza Mushtaq, Syed Mohsin Raza, Adeel Ahmad, Hina Aslam, Sunia Karam Din, et al.
…nvolves the administration of a panel of five antimicrobial drugs for the period of 6 months. The purpose of this study was to determine antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure and to determine efficacy of the second l…
E. E. Lesnik, S. Ginda
…e main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective stud…
Kamolwat P, Nateniyom S, Chaiprasert A, Disratthakit A, Mahasirimongkol S, et al.
Objective To assess the prevalence and risk factors of drug-resistant tuberculosis (TB), the fifth national anti-TB drug resistance survey was conducted in Thailand. Methods A cross-sectional study was conducted by stratified cluster sampling with probability proportional to size…
Anderson K, Pietersen E, Shepherd BE, Bian A, Dheda K, et al.
…een HIV-positive and HIV-negative South African adults with drug-resistant tuberculosis (DR-TB) and high incidence of acquired second-line drug resistance. Methods We performed a retrospective review of DR-TB patients with serial second-line TB drug susceptibility tests (2008-201…
Muhammad Novran Chalik, Alif Fathurrachman, Linda Andriani, Rouly Pola Pasaribu, Sudarto, et al.
…on immunity, there are two types of pulmonary TB infection: drug-sensitive and drug-resistant. Based on ATD sensitization tests, MTb resistance types consist of TB that is monoresistant, polyresistant, multidrug resistance (MDR), pre-extensively drug resistant (Pre-XDR), extensiv…
Olivia Marsha Maritsa, Ni Made Mertaniasih, Ariani Permatasari, Tutik Kusmiati
…the world. This study aims to determine patterns of anti-TB drug resistance in drugresistant TB patients in Dr. Soetomo Academic Hospital from January 2022 to December 2023. This was a descriptive retrospective using patient medical record data in Dr. Soetomo Academic Hospital fo…
Cui ZJ, Zhang WT, Zhu Q, Zhang QY, Zhang HY
…vaccines, TB has again become a threat because of increased drug resistance. There is still a lack of effective treatment regimens for a person who is already infected with multidrug-resistant Mtb (MDR-Mtb) or extensively drug-resistant Mtb (XDRMtb). In the past decades, many res…
Bwire Wilson Bwire, Maurice C Y Mbago, Amina S Msengwa
**BACKGROUND:** The prevalence of tuberculosis (TB) multi-drug resistance is increasing worldwide, including in Tanzania. This trend hinders the attainment of sustainable development goal number three as it increases the number of cases of the disease and treatment costs. Fewer c…
Lei Wang, Zhidong Teng, Ramziya Rifhat, Kai Wang
Tuberculosis has been prevalent in Xinjiang with severe drug resistance situation. It is unclear that which Mycobacterium tuberculosis (M.tb) infections (drug sensitive or drug resistant) most affected the tuberculosis incidence, how to identify the relative contribution of prima…
Hailemariam TG, Ayele A, Gelanew T, Atnafu A, Brennan M, et al.
…jor global health challenge, particularly due to increasing drug resistance. Beyond the well-characterized mutations, the mechanisms involved in driving resistance appear to be more complex. This study investigated the differential gene expression of Ethiopian drug-resistant Mtb …
P Sudha Kumari, M Siva Durga Prasad Nayak, Usha Devi, Susmita Susmita, SG Sushma
…f the World Health Organisation (WHO) on the disease. Multi-Drug Resistant TB (MDR-TB) cases have been increasing in India. About half of the world’s MDR-TB cases are present in India. Aim: To assess the incidence of drug resistant TB in Prakasam district, Andhra Pradesh, India, …
Che Y, Yang T, Lin L, Xiao Y, Jiang F, et al.
Setting: Programmatic management of drug-resistant tuberculosis in Ningbo, China. Objective: To assess whether data-driven genetic determinants of drug resistance patterns could outperform phenotypic drug susceptibility testing in predicting clinical meaningful outcomes among pat…
Mevlüt Karataş, Tülin Kuyucu, Tülin Sevim
…btained from TB surveillance forms, bacteriology laboratory drug resistance database and octomed patient follow-up program. Results: N=1146 (65.4%) of the cases were male and n=607 (34.6%) were female. The male/female ratio was 1.8 and the highest cases were observed in the 15-24…
Hiral Gadhavi, Akansha Goyal, Binita Aring, Summaiya Mullan
The rate of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has been steadily increasing in developing countries like India. The availability of rapid and reliable methods for the detection of drug resistance to second-line drugs is vital for adeq…
Paryani RH, Gupta V, Singh P, Verma M, Sheikh S, et al.
… is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB an…
Norbert Ndjeka, Nazir Ismail
Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrug-resistant tuberculosis. Both drugs have been in use in South Africa at least 10 years: bedaquiline since 2007 and clo…
Hongkuan Yang, Yahong Cheng, Haoli Ma, Y. Li, Bei Han
Objective: To understand the epidemic status of drug-resistant Mycobacteriun tuberculosis in Xi'an in the past three years, and the impact of COVID-19 epidemic during 2020 so as to provide basic information for local multidrug-resistant tuberculosis (MDR-TB) prevention and treatm…
Shah V, Yogesh M, Kothari DR, Gandhi RB, Nagda JJ
Background Characterizing risk factors for drug-resistant tuberculosis (TB) is critical to guide targeted interventions in high-burden settings like India. We aimed to identify socioeconomic, lifestyle, and clinical factors associated with drug-sensitive and drug-resistant TB acq…
Xiujuan Zhao, Lin Liu, Xingyong Wu, Sijing Li, Biao Liu, et al.
Abstract BackgroundThe emergence of antimicrobial resistance against mycobacterium tuberculosis has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug-resistant…
O'Toole RF
…demic has had on the control of tuberculosis (TB) including drug-resistant forms of the disease. Antimicrobial resistance increases the likelihood of worsened outcomes in TB patients including treatment failure and death. Multidrug-resistant (MDR) strains, resistant to first-line…
Nattakarn Preehativong
… health problem in Thailand according to the high burden of drug resistant tuberculosis. The drugs used in the treatment of drug resistant tuberculosis are classified as new drugs or drugs with new indications that need to use with precautions in closely monitoring This article w…
Liu D, Huang F, Zhang G, He W, Ou X, et al.
Objectives Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug resistance is slow and unreliable, limiting individualized therapy and monitoring of national TB data. Our study evaluated whole-genome sequencing (WGS) for its predictive accuracy, use in …