Showing 76–100 of 200 documents
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Preeti Sharma, Jinendra Singh Chauhan, Birjesh Singh
…dosing, incomplete treatment course, and the ability of the tuberculosis bacilli to tolerate and survive current first-line and second-line anti-TB drugs, in either their latent state or active state, has resulted in an increased prevalence of multidrug-resistant (MDR), extensive…
Chaiyachat P, Kaewseekhao B, Chaiprasert A, Kamolwat P, Nonghanphithak D, et al.
…of pre-extensively (pre-XDR) and extensively drug-resistant tuberculosis (XDR-TB) is challenging. Drug-susceptibility tests for some anti-TB drugs, especially ethambutol (ETH) and ethionamide (ETO), are problematic due to overlapping thresholds to differentiate between susceptibl…
Sonnenkalb L, Strohe G, Dreyer V, Andres S, Hillemann D, et al.
…tment failure of multi/extensively drug resistant (MDR/XDR) tuberculosis (TB). Intrapatient evolutionary dynamics of Mycobacterium tuberculosis complex (Mtbc) strains and their implications on treatment outcomes are still not completely understood. To elucidate how Mtbc strains e…
Omar SV, Louw G, Ismail F, Liu X, Ngcamu D, et al.
Drug-resistant tuberculosis (TB) poses a significant public health concern in South Africa due to its complexity in diagnosis, treatment, and management. This study assessed the diagnostic performance of the Xpert MTB/XDR test for detecting drug resistance in patients with TB by …
Gaurav Sharma, Bharti Malhotra, P. J. John, Shipra Bhargava
…ain purpose of this study is the detection of Mycobacterium tuberculosis (MTB) and its drug resistance profile by molecular methods in pediatric patients suspected of pleural tuberculosis. Children ≤ 15 years of age suspected of pleuritis were enrolled in this study. Total 176 pl…
Diana Vakhrusheva, Kseniya Belousova, Tatyana Umpeleva, Natalya Eremeeva
…sults of drug susceptibility testing (DST) of Mycobacterium tuberculosis (Mtb) isolated from the sputum of the patient at the preoperative stage of treatment and from its surgical material. <b>Aim:</b> Analysis of the results of DST of Mtb isolated from surgical and respiratory m…
Harun Patel, Iqrar Ahmad, Harsha Jadhav, Rahul Pawara, Anand B. Mundada, et al.
…is the 9th leading cause of death worldwide above HIV/AIDS. Tuberculosis (TB) management remains challenging due to the emergence of drug-resistant tuberculosis such as MDR-TB and XDR-TB. To improvise therapeutic results for MDR/XDR-TB, 89 nations had started utilizing bedaquilin…
Younghun Kim, Da-Gyum Lee, Jinyoung Bae, Jihee Jung, Hyeongrin Jeon, et al.
…tidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB); however, mutations related to LZD resistance still need to be characterised. This study investigated resistance-related mutations on a whole-genome scale in clinical isolates from patients with MDR/XDR…
Diriba G, Alemu A, Yenew B, Tola HH, Gamtesa DF, et al.
…stimate the pooled proportion of extensively drug-resistant tuberculosis (XDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) in patients with multidrug-resistant TB (MDR-TB). Methods We systematically searched articles from electronic databases: MEDLINE (PubMed)…
Merker M, Rasigade JP, Barbier M, Cox H, Feuerriegel S, et al.
…ansmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the largest single contributor to human mortality due to antimicrobial resistance. A few major clades of the Mycobacterium tuberculosis complex belonging to lineage 2, responsible for high prevalence…
Puspa Acharya, N. K. Bhattarai, Bhuban Raj Kunwar, Khem R. Sharma, Vijay Kumar Khanal, et al.
Abstract Background Drug-resistant tuberculosis poses a significant threat to global TB control efforts, potentially reversing progress made in reducing TB-related morbidity and mortality. This study aims to identify risk factors for multidrug-resistant TB [MDR-TB] in Province 3,…
Lin M, Chen YW, Li YR, Long LJ, Qi LY, et al.
…-based assays used for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and drug-resistant tuberculosis (DR-TB). But studies on its performance are insufficient. Thus, in this study, we conducted a systematic review and meta-analysis to evaluate the effect of LPAs in the d…
Trisakul K, Nonghanphithak D, Chaiyachat P, Kaewprasert O, Sakmongkoljit K, et al.
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) make TB difficult to control. Global susceptibility data for six newly recommended anti-TB drugs against M/XDR-TB are still limited. Using publicly available whole-genome sequences, we …
Xu Y, Li Q, Zhu M, Wu X, Wang D, et al.
…idemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China.From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years old) were enrolled retrospectively. Epidemiolo…
Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi, Saeid Besharati, Ali Akbar Velayati
…model of latency in same clinical isolates of Mycobacterium tuberculosis (MTB). Methods: MTB strains were isolated from clinically and laboratory-confirmed cases of tuberculosis (TB). The TB isolates were subjected to the Xpert MTB/rifampin test and then, further susceptibility t…
Sharma A, De Rosa M, Singla N, Singh G, Barnwal RP, et al.
Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued humanity for centuries and has claimed numerous lives across the globe. Concerted efforts by researchers have culminated in the development of various strategies to combat this malady. This rev…
Pratik Kumar, Amardeepak Toppo, Roshan Lal, Sagarika Pradhan, Puneet Bhardwaj
…nd: There is an increasing incidence of multidrug-resistant tuberculosis (TB)/preextensively drug-resistant TB (XDR TB) and XDR TB globally. Therefore, rapid diagnostic tests with good sensitivity and specificity are need of hour. Truenat Mycobacterium tuberculosis (MTB) is one s…
Mokry J, Porvaznik I, Kusnir P, Dohal M, Solovic I
The incidence of tuberculosis (TB) in some countries increases continuously, especially caused by mycobacterial strains resistant to various anti-tuberculotic drugs (AT). The emergence and spread of drug-resistant tuberculosis (multidrug-resistant - MDR-TB, and extensively drug-r…
Burhan E, Karyana M, Karuniawati A, Kusmiati T, Wibisono BH, et al.
…are lower than global testing rates per the 2020 WHO global tuberculosis (TB) report, prevalence of multidrug-resistant TB may be underestimated. Our study aimed to evaluate prevalence and patterns of TB drug resistance (DR) within Indonesia. We conducted a cross-sectional analys…
Girija Shankar Udgata, Srikanta Dash -
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), one of the top 10 causes of death worldwide (ranking above HIV/AIDS). About a quarter of the world's population is infected with TB and thus at risk of developing TB disease. The Global TB Repo…
Thanaphon Yisankhun, Saran Sujinpram, Phimruethai Chongkratok, Sattawat Sanmai, Vatcharapong Sungketkit, et al.
… hospital was confirmed with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) after a delay of over 30 days following an abnormal chest X-ray (CXR). We investigated to verify the outbreak and diagnosis, describe its characteristics, review the HCW TB screening program, an…
Dr Hariharan
Background: Tuberculosis (TB) is a chronic infectious disease that has afflicted mankind for 5000 years. It has caused more deaths in adults than any other infectious disease The emergence of multidrug-resistant (MDR) TB has introduced challenging, but surmountable, complexities …
Basingnaa A, Antwi-Baffour S, Nkansah DO, Afutu E, Owusu E
The emergence of multidrug-resistant tuberculosis (MDR⁻TB) and more recently, extensively drug-resistant (XDR) TB has intensified the need for studies aimed at identifying factors associated with TB drug resistance. This study determined the differences in plasma concentrations o…
Osei-Wusu S, Amo Omari M, Asante-Poku A, Darko Otchere I, Asare P, et al.
Background Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug resistance among diverse primary drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates in Ghana. Materials…
Ncha R, Variava E, Otwombe K, Kawonga M, Martinson NA
…s predictive of TTSCC in patients with multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in the North-West Province. Methods A retrospective cohort study, abstracting patient demographic and clinical data, laboratory results, dates of…