Showing 76–100 of 200 documents
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Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Camron Pearce, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Ju Mi Lee, Jiyun Park, Sang‐Won Choi, Byung Woo Jhun, Su‐Young Kim, et al.
…se (MAC-PD) remain unsatisfactory. Thus, improved treatment regimens for MAC-PD are required. Clofazimine has recently been revisited as an effective drug against mycobacterial infection. We performed a comparison between the standard regimen and an alternative regimen (replacing…
Raehan Satya Deanasa, Arya Marganda Simanjuntak, Fara Syafira, Putri Mahirah Afladhanti, Anisa Hawari, et al.
… and moxifloxacin was active in ABSTRACT INTRODUCTION Newer regimens are needed and expected to have a shorter therapeutic time to increase drug adherence to completion in drug sensitive tuberculosis (DS-TB) patients.METHODS We conducted first a systematic review and meta-analysi…
Kohler S, Sitali N, Achar J, Paul N
…nd their import are costly. We assessed how shorter TB drug regimens, which were non-inferior or superior in recent TB trials, can affect the costs for purchasing and importing TB drugs. Methods We estimated the drug costs and import costs of 39 longer and shorter TB drug regimen…
Adriana Chacón, Yamile Celis Bustos, Dany Martinez, Felix Chong, Clara Freile, et al.
…ogrammatic cohort, the nine-month all-oral shorter and BPaL regimens were associated with favorable treatment outcomes, acceptable safety profiles, improved adherence, and reduced loss to follow-up compared with injectable-based therapy. These findings supported Ecuador’s …
Gupta A, Juneja S, Babawale V, Rustam Majidovich N, Ndjeka N, et al.
…e rollout of new WHO-recommended shorter all-oral treatment regimens for drug-resistant TB (DR-TB), which remains a public-health crisis. The all-oral, 6-month BPaL/M regimen comprises 3-4 drugs: pretomanid used in combination with bedaquiline and linezolid, with or without moxif…
Ryckman TS, Schumacher SG, Lienhardt C, Sweeney S, Dowdy DW, et al.
…tent to which future improvements in tuberculosis treatment regimens could offset potential increases in drug costs. Methods In this modelling analysis, we used an ingredients-based approach to estimate prices at which novel regimens for rifampin-susceptible and rifampin-resistan…
Muniyandi M, Ramesh PM, Wells WA, Alavadi U, Sahu S, et al.
Objective To measure the economic impacts of the longer pre-XDR-TB treatment regimen and the shorter BEAT-TB India regimen. Methods In the current study, the economic impacts of the current 18-month pre-XDR-TB treatment regimen and the 6-9 month BEAT-TB regimen were evaluated usi…
Vijay Kumar, G S Sri Bharathi, Mohit Bhatia, Sankha Shubhra Chakrabarti, Upinder Kaur, et al.
…nalyze therapeutic outcomes with bedaquiline-based all-oral regimens for drug-resistant tuberculosis. A prospective observational study was conducted from August 2022 to March 2024 and patients of drug-resistant tuberculosis on all-oral regimens were enrolled. Among 100 patients …
Khan PY, Franke MF, Hewison C, Seung KJ, Huerga H, et al.
…le agents, in use for decades, and endorsed all-oral longer regimens. However, questions remain about the role of the injectable agent, particularly in the context of regimens using new and repurposed drugs. We compared the effectiveness of an injectable-containing regimen to tha…
Malaisamy Muniyandi, Balaji Ramraj, Sathishkumar Vadamalai, Sahil Abdul Salam, Bella Devaleenal, et al.
**BACKGROUND:** Short-course regimens are currently explored to improve multidrug-resistant tuberculosis effects, reduce costs, as well as enhance patient adherence. Currently, we are determining the most cost-effective shorter regimen out of seven short-course regimens (6-9 …
Nguyen TMP, Nguyen BH, Hoang TTT, Nguyen HA, Vu DH, et al.
…on (WHO) recently recommended standardized all-oral shorter regimens for rifampicin resistant Tuberculosis (RR-TB). For highly resistant Tuberculosis patients such as pre-XDR-TB: RR-TB plus additional resistance to fluoroquinolones (FQ), the 6-9-months bedaquiline (bedaquiline)-b…
Norbert Ndjeka, Rubeshan Perumal, Kamila Romanowski, Hlengani Mathema, Lateef Babatunde Amusa, et al.
**BACKGROUND:** Shorter all-oral regimens for the treatment of multidrug-resistant tuberculosis or rifampicin-resistant tuberculosis (MDR/RR-TB) have improved efficacy, but their performance under programmatic conditions remains insufficiently characterized. **METHODS:** We retr…
В. П. Гусева, Irina Vasilyeva, V. V. Testov
…dities. Therefore, developing alternative shortened therapy regimens with a favourable safety profile and proven efficacy remains an urgent task. Objective To compare the effectiveness of treatment of pulmonary TB with preserved susceptibility of M. tuberculosis to isoniazid, rif…
J. A. M. Raaijmakers, Mike Marvin Ruth, Jodie A. Schildkraut, Erik van den Hombergh, Rob E. Aarnoutse, et al.
…ls infected with M. avium ATCC 700898 were exposed to these regimens for 21 d. PK profiles were determined at d 0 and d 21. The pharmacodynamic effect was measured by determining bacterial densities at d 0, 3, 7, 14 and 21 for intra- and extracellular fractions. Emergence of macr…
J van Ingen, F -Q ter Bruggen, A Lemson, W Hoefsloot
…cure in MAC-PD patients treated with clofazimine-containing regimens at a Dutch tertiary care center. Methods Single-centre retrospective cohort study of adults with macrolide-susceptible MAC-PD who initiated treatment with clofazimine as part of either a standard ethambutol-macr…
Ilangovan Ilavarasan, Vidhyanathan Ariharanathan, Chandrasekaran Sabitha Devi
…CI). Conclusion: The weekly HP regimen is superior to other regimens in reducing the incidence of TB. Additionally, the duration of the HP regimen is shorter compared to the commonly advised nine-month Isoniazid regimen. Compared with the daily dosage of Isoniazid, the weekly HP …
Ionescu AM, Mpobela Agnarson A, Kambili C, Metz L, Kfoury J, et al.
…ared the cost-effectiveness of bedaquiline (BDQ) containing regimens with injectable containing regimens (short-course regimen [SCR] and long-course regiman [LCR]) in India, Russia, and South Africa. Methods The analysis evaluated the direct costs of DR-TB treatment which include…
Xinxin Zeng, Hao Xu, Aole Li, Juanjuan Liu, Yuhang Wu, et al.
…for childhood tuberculosis (TB), evaluation of TB treatment regimens for children in real-world settings in China remained limited, particularly regarding treatment duration, utilization of second-line anti-TB drugs (SLDs), and adverse events. This study aimed to describe the tre…
Hasan T, Medcalf E, Nyang'wa BT, Egizi E, Berry C, et al.
…cal considerations in shifting to shorter tuberculosis (TB) regimens. Novel 6-month oral regimens that include bedaquiline (B), pretomanid (Pa), and linezolid (L), with or without a fourth drug, have been shown to be as or more effective than the established longer regimens for t…
Yilin Zhang, Yang Li, Yuanyuan Chen, Cui Cai, Hengzhong Yi, et al.
…IVES:** Effective rifampicin-resistant tuberculosis (RR-TB) regimens often include multiple QT-prolonging drugs, necessitating evaluation across different combinations. **METHODS:** Using pooled electrocardiogram data from two trials, three QT-prolonging shorter regimens for RR-…
Thi Mai Phuong Nguyen, Van Luong Dinh, Binh Hoa Nguyen, Thi Thanh Thuy Hoang, Viet Nhung Nguyen, et al.
…in-resistant TB (RR-TB) burden country. Different new RR-TB regimens were recommended in recent years. Locally-generated evidence about nationwide implementation of different RR-TB regimens is essential to inform national treatment guidelines. **METHODS:** A retrospective cohort…
Hélène E. Aschmann, Allan Musinguzi, Jillian L. Kadota, Catherine Namale, Juliet Kakeeto, et al.
…f offered different tuberculosis preventive treatment (TPT) regimens, and under which conditions they would accept treatment. Actionable evidence regarding preference for TPT is needed to inform policy and the development of novel TPT regimens. Methods: Adults engaged in care at …
Y. I. Feshchenko, N.А. Lytvynenko, L.M. Protsyk, M.V. Pohrebna, Yu.О. Senko
BACKGROUND. Six-month short-term treatment regimens for drug-resistant tuberculosis (DR-TB) are more effective and better tolerated compared to longer regimens. There is a need to develop a clear algorithm for their prescription. OBJECTIVE. To develop a clinical algorithm for sel…
Y. I. Feshchenko, N.А. Lytvynenko, L.M. Protsyk, M.V. Pohrebna, Yu.О. Senko
BACKGROUND. Six-month short-term treatment regimens for drug-resistant tuberculosis (DR-TB) are more effective and better tolerated compared to longer regimens. There is a need to develop a clear algorithm for their prescription. OBJECTIVE. To develop a clinical algorithm for sel…