Showing 51–75 of 200 documents
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Ohno S, Umebayashi I, Matsukawa M, Goto T, Yano T
…er, the long-term safety profile and efficacy in real-world clinical settings in patients with RUBD have not been fully clarified. The BRIGHT study, a prospective, large-scale, long-term postmarketing surveillance (PMS) study, was conducted to investigate the long-term safety and…
Hayley A. Scott, Lisa G. Wood, Evan J. Williams, Natasha Weaver, John W. Upham
…cipants (75% female; mean age, 33.4 [9.9] yr) completed the trial. Moderate exercise induced a significant reduction in sputum eosinophil count (−173 [−337 to −10]; P = 0.032) and sputum percentage eosinophils (−2.2 [−4.9 to 0.5]; P = 0.049) relative to control. Vigorous exercise…
Moosa MS, Maartens G, Gunter H, Allie S, Chughlay MF, et al.
…We conducted a randomized, double-blind, placebo-controlled trial to assess the efficacy of intravenous NAC in hospitalized adult patients with anti-tuberculosis drug-induced liver injury (AT-DILI). The primary endpoint was time for serum alanine aminotransferase (ALT) to fall be…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Baluku JB, Ronald O, Bagasha P, Okello E, Bongomin F
…Web of Science, the Cochrane Central Register of Controlled Trials, mRCTs, Clinical trials.gov, and International Clinical Trials Registry Platform from inception to 31st December 2021. Among 110 eligible studies, 79 (238,316 participants) were included in the meta-analysis for s…
Zeguang Zheng, Kai Yang, Geoffrey Liu, Xiuhua Fu, Huijie He, et al.
…nter, randomized, double-blind, placebo-controlled, phase 3 trial at 19 centers in China. Hospitalized adult patients with mucopurulent sputum and expectoration difficulty were recruited. Patients were randomized by 1:1 to receive inhalation of either ambroxol hydrochloride solut…
Shi W, Hu Y, Zheng X, Ning Z, Wu M, et al.
…n alterations in gut microbiota composition and unfavorable clinical outcomes. Methods The study is a multicenter, observational prospective cohort study. Three study sites are purposively selected in the western (Sichuan Province) and eastern (Jiangsu Province and Shanghai) part…
Millard JD, Mackay EA, Bonnett LJ, Davies GR
… Methods We will search for randomised and quasi-randomised clinical trials in adult participants with and without the inclusion of PZA in TB treatment regimens in the Cochrane infectious diseases group's trials register, Cochrane central register of controlled trials (CENTRAL), …
Hills NK, Lyimo J, Nahid P, Savic RM, Lienhardt C, et al.
…osis (TB). However, the current practice in TB therapeutics trials is to use composite binary outcomes, which in the absence of standardization may inflate false positive and negative errors in evaluating regimens. The lack of standardization of outcomes is a barrier to the ident…
Xie F, Duan Z, Zeng W, Xie S, Xie M, et al.
… 159 CAP patients to assess the diagnostic performance of a clinical metagenomics assay and its impact on clinical management and patient outcomes. When compared to other techniques, clinical metagenomics detected more pathogens in more CAP cases, and identified a substantial num…
Ye Q, Wang H, Xia X, Zhou C, Liu Z, et al.
…ls (DPSCs) in treating severe pneumonia caused by COVID-19. Trial design This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial. Participants Twenty serious COVID-19 cases will be enrolled in the trial from April…
Rudolf F, Abate E, Moges B, Mendes AM, Mengistu MY, et al.
Background The Bandim TBscore is a clinical score that predicts treatment outcome in Tuberculosis (TB) patients and proved useful as an indicator of which healthcare-seeking adults to refer for sputum smear microcopy. We aimed to test in a randomized trial if the TBscore could be…
Human Sciences Research Council
…his pragmatic, open-label, individual randomised controlled trial was done in nine clinics in Johannesburg, South Africa. Participants (aged ≥18 years) undergoing investigation for tuberculosis were randomly assigned (1:1) to the intervention group or control group (standard of c…
Jagannath Purushothama
…ebo controlled, block- randomized, double-arm, single blind trial will be experimented between March 2019 and August 2022 in Mangaluru, India, with a sample size of 300 in both the arms. The intervention group will be prescribed with nicotine polacrilex chewing gums along with br…
Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… in the field of TBM over the last two decades and only few trials have evaluated a composite of these strategies in the overall outcomes of TBM. Methods An open label, parallel arms, randomized controlled superiority trial will be conducted among 372 participants across 6 sites …
Bjerrum S, Schiller I, Dendukuri N, Kohli M, Nathavitharana RR, et al.
…d symptoms).The proposed role for LF-LAM is as an add on to clinical judgement and with other tests to assist in diagnosing tuberculosis. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register; MEDLINE, Embase, Science Citation Index, Web of Scienc…
Horne DJ, Kohli M, Zifodya JS, Schiller I, Dendukuri N, et al.
…n Health Sciences Literature, Scopus, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number Registry, and ProQuest, to 11 October 2018, without language restriction. Selection criteria Randomized trials, cross-secti…
Yoshihiro Kanemitsu, Motohiko Suzuki, Kensuke Fukumitsu, Takamitsu Asano, Norihisa Takeda, et al.
…indicators of Th2-driven inflammation in the lower airways. TRIAL REGISTRATION: This study was registered on the UMIN Clinical Trials Registry (Registry ID UMIN000018672).
Kohli M, Schiller I, Dendukuri N, Yao M, Dheda K, et al.
…atin American Caribbean Health Sciences Literature, Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number Registry, and ProQuest, 2 August 2019 and 28 January 2020 (Xpert Ultra studies), …
Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, et al.
…ican Caribbean Health Sciences Literature (LILACS), Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number (ISRCTN) Registry, and ProQuest up to 7 August 2017 without language restriction.…
Chang Liu, Xin Wang, Yue Wang, Yuanyu Zhao, Huiwen Guan, et al.
…he anesthesia management of double-lumen endotracheal tube. Trial registration : This clinical research was registered at the Chinese Clinical Trial Registry(www.chictr.org.cn,ChiCTR2000040188).
J. Nancy Hilda, Gopalan Narendran, Banu Rekha VV, Elizabeth Hanna Luke, Ponnuraja Chinnaiyan, et al.
…our to prevent mortality caused by this co-infection. <bold>Clinical trial registration:</bold> Two studies were registered with the Clinical Trial Registry (CTRI 2008/091/000024 & NCT00933790).
Xiao Li, Li Wen, Lianjie Sun, Junyi Ren, Ying Xu, et al.
… dysfunction. Reducing pulmonary inflammation and improving clinical symptoms is the focus of current treatment. Low-intensity pulsed ultrasound (LIPUS) can mitigate inflammation and inhibit edema formation. We aimed to investigate the efficacy of therapeutic LIPUS in improving l…
Xiong K, Cai J, Liu P, Wang J, Zhao S, et al.
…ug-induced liver injury in animal experiments. However, the clinical evidence is absent. The objective is to investigate the effect of adjunctive Lactobacillus casei on tuberculosis-drug-induced liver injury. Methods and results A post hoc analysis is conducted for a previous ran…