Showing 51–75 of 200 documents
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Fritschi N, Curtis N, Ritz N
The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tubercul…
Negi K, Bhaskar A, Dwivedi VP
…t to improve the TB control program comprising one approved vaccine, M. bovis Bacille Calmette-Guerin (BCG) has directed researchers to explore progressive approaches to halt the eternal TB pandemic. Mycobacterium tuberculosis ( M.tb ) was first identified as the causative agent …
van den Berg RA, De Mot L, Leroux-Roels G, Bechtold V, Clement F, et al.
…s the potential to identify gene signatures associated with vaccine immunogenicity and protective efficacy. The main objective of this study was to identify optimal postvaccination time points for evaluating peripheral blood RNA expression profiles in relation to vaccine immunoge…
Wu Y, Cai M, Ma J, Teng X, Tian M, et al.
Adults are the leading population affected by tuberculosis (TB) epidemic and death. Developing an effective vaccine against adult TB is urgently needed. Mycobacterium bovis Bacillus Calmette-Guerin (BCG) prime-heterologous boost strategy has been explored extensively to protect a…
Nilofer Naqvi, Anwar Alam, Mohd Shariq, Yashika Ahuja, Dipendra K Mitra, et al.
…a global health burden, particularly because of the limited efficacy of the Bacillus Calmette-Guérin (BCG) vaccine against adult pulmonary TB. To improve immunogenicity, we developed a recombinant BCG strain expressing the M. tuberculosis -specific antigen Rv1507A (rBCG_Rv15…
Marcellus Korompis, Christopher J De Voss, Shuailin Li, Alberta Ateere, Helen McShane, et al.
…and mortality worldwide, and Bacillus Calmette-Guérin (BCG) offers inconsistent protection against adult pulmonary TB. We previously showed that homologous mRNA vaccination encoding the mycobacterial antigen PPE15 (mRNA.PPE15) enhanced immunogenicity but did not improve prot…
Yun JS, Shin E, Lee YR, Lee JA, Lee H, et al.
Introduction The inadequate efficacy of the Bacillus Calmette-Guérin (BCG) vaccine against adult pulmonary tuberculosis (TB) necessitates the development of new and effective vaccines. Human adenovirus serotype 5 (Ad5), which induces T-cell response, is a widely used viral vector…
Adesanya OA, Uche-Orji CI, Adedeji YA, Joshua JI, Adesola AA, et al.
Background The Bacillus Calmette-Guerin (BCG) vaccine has been in use for 99 years, and is regarded as one of the oldest human vaccines known today. It is recommended primarily due to its effect in preventing the most severe forms of tuberculosis, including disseminated tuberculo…
Ramos L, Lunney JK, Gonzalez-Juarrero M
Neonatal and infant immunity differs from that of adults in both the innate and adaptive arms, which are critical contributors to immune-mediated clearance of infection and memory responses elicited during vaccination. The tuberculosis (TB) research community has openly admitted …
Singh S, Saavedra-Avila NA, Tiwari S, Porcelli SA
Bacillus Calmette-Guerin (BCG) has been used as a vaccine against tuberculosis since 1921 and remains the only currently approved vaccine for this infection. The recent discovery that BCG protects against initial infection, and not just against progression from latent to active d…
Thomas E. Tavolara, Muhammad Khan Niazi, Gillian Beamer, Metin N. Gürcan
…utcomes, vaccination with M. bovis Bacille Calmette-Guerin (BCG) vaccine is used globally in children to prevent systemic disease and tuberculous meningitis. However, in adults, epidemiological studies show variable protection ranging from 0% to 80%. As a part of a larger study t…
Kumar P
TB continues to be one of the major public health threats. BCG is the only available vaccine against TB and confers significant protection against the childhood disease. However, the protective efficacy of BCG against adult pulmonary TB, which represents a larger burden of diseas…
Ali SH, Shakir S, Shaikh UA, Khalid M, Jawed M, et al.
…bal cause of death. While primary Bacillus Calmette-Guérin (BCG) vaccination offers protection in children, the role of BCG revaccination in adults remains unclear. This study evaluated the efficacy, immunogenicity, and safety of BCG revaccination against TB. A comprehensive lite…
Korompis M, De Voss CJ, Li S, Richard A, Almujri SS, et al.
BCG remains the only licensed vaccine for tuberculosis (TB), but its efficacy wanes over time. Subunit vaccines, aim to improve BCG immunity and protection, by inducing responses to a few mycobacterial antigens delivered with a specific platform. Since the platform shapes the imm…
Ferluga J, Yasmin H, Bhakta S, Kishore U
…mmunometabolism, and other environmental factors. Till now, BCG is the only vaccine available to prevent TB but the protection rendered by BCG against pulmonary TB is not uniform. To deliver a vaccine which can give consistent protection against TB is a great challenge with risin…
Ginsberg AM
…s (TB) is the leading infectious killer globally and new TB vaccines will be crucial to ending the epidemic. Since the introduction in 1921 of the only currently licensed TB vaccine, BCG, very few novel vaccine candidates or strategies have advanced into clinical efficacy trials.…
Mourits VP, Koeken VACM, de Bree LCJ, Moorlag SJCFM, Chu WC, et al.
BCG vaccination protects not only against tuberculosis but also against heterologous infections. This effect differs between individuals, yet the factors responsible for this variation are unknown. BCG-induced nonspecific protection is, at least partially, mediated by innate immu…
Trim Lajqi, Natascha Köstlin‐Gille, Christian Gille
… innate immune cells to exhibit rapid action with increased efficacy against subsequent infections. Here we will discuss the role of TRIM and its implications for infectious diseases in childhood. The Concept of Trained Innate Memory Although lacking an adaptive immune system, pl…
Wang R, Fan X, Xu D, Li M, Zhao X, et al.
Bacillus Calmette-Guérin (BCG) is the only widely used prophylactic tuberculosis (TB) vaccine that can prevent severe TB in infants. However, it provides poor protection in adults, and therefore, there is ongoing research into new TB vaccines and immunization strategies with more…
Nisa A, Counoupas C, Pinto R, Britton WJ, Triccas JA
Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the only approved vaccine against tuberculosis (TB). However, its efficacy in preventing pulmonary TB in adults is limited. Despite its variable efficacy, BCG offers a number of unique and beneficial characteristics, which mak…
Mao LR, Du JP, Wang XC, Xu LF, Zhang YP, et al.
…dormant Mycobacterium tuberculosis is an important cause of adult tuberculosis (TB) transmission. According to the interaction mechanism between M. tuberculosis and the host, the latency antigen Rv0572c and region of difference 9 (RD9) antigen Rv3621c were selected in this study …
Carine Rouanet, Anne-Sophie Debrie, Stephane Cauchi, Nathalie Mielcarek
…ency. BPZE1 is the most advanced, next-generation pertussis vaccine undergoing clinical evaluation in children and adults. We investigated the feasibility of co-administering BPZE1 and Bacillus Calmette-Guerin (BCG), the most widely used tuberculosis vaccine worldwide. We showed …
Heijmenberg I, Husain A, Sathkumara HD, Muruganandah V, Seifert J, et al.
…ng infectious cause of death globally. The only licensed TB vaccine, Bacille Calmette-Guérin (BCG), has low efficacy against TB in adults and is not recommended in people with impaired immunity. The incorporation of the Mycobacterium tuberculosis (Mtb) secretion system ESX-1 into…
Soo-Min Kim, Jin-Seung Yun, EunJung Shin, Jinhee Lee, You-Jin Kim, et al.
…al health challenge, and the Bacillus Calmette-Guérin (BCG) vaccine has limited efficacy against adult pulmonary disease. Protein subunit vaccines are a promising alternative but require strong adjuvants to induce cell-mediated immunity. Synthetic agonists targeting toll-lik…
Moonsu Lee, Dohyeon Jeong, Kiyoung Yoon, Juyoung Jin, Yong Woo Back, et al.
…023, despite the century-old Bacillus Calmette-Guérin (BCG) vaccine. BCG's protective efficacy diminishes over time, especially against pulmonary TB in adults. This study evaluates ethanol-inactivated() delivered via Microneedle Array Patches (MAPs) as a novel booster strate…