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Seyed Saeed Hashemi Nazari, Saeid Fallah, Vahideh Raeisi
Context The number of tuberculosis (TB) patients and multidrug-resistant species of Mycobacterium tuberculosis are increasing worldwide. Effective treatment is still the key factor to control TB in the society. Aims The aim of the study was to compare the efficacy of fixed-dose c…
Alex Nachman, Zain Chagla
CLINICAL IMPACT RATINGS: GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text] Pulmonology: [Formula: see text].
Sacks HS
Source citation Paton NI, Cousins C, Suresh C, et al; TRUNCATE-TB Trial Team. Treatment strategy for rifampin-susceptible tuberculosis. N Engl J Med. 2023;388:873-887. 36808186.
Tushar R. Sahasrabudhe
… Revised National TB Control Programme (RNTCP) as DOTS plus regimens. These regimens involved use of less potent second-line drugs which were at least 5 and up to 7 in number based on grouping of medicines, and were required to be taken for a longer duration, often ranging from 1…
Nirmal Kumar Jain
…ed guidelines published in March 2020 recommends fully oral regimens for drug-resistant tuberculosis (DR-TB) that is isoniazid-resistant TB, rifampicin-resistant TB (RR-TB), multi-DR-TB (MDR-TB), and extensively DR-TB (XDR-TB). These regimens are said to be game changer for these…
Durga Balagopalan
All oral regimens have become a great advancement in the treatment of multidrug-resistant tuberculosis (MDR-TB). Earlier, the treatment of MDR-TB was considered long, with side effects and more relapse rate. The best estimate of the proportion of people diagnosed with MDR/Rifampi…
Courtney M. Yuen, Moorine Sekadde, Brian Kaiser, Brenda Waning, Stephen M. Graham
…for TB disease or infection, the length of common treatment regimens poses a challenge to the implementation of child-friendly TB care. Undergoing TB disease treatment, which previously ranged from 6 months for drug-sensitive TB to up to 2 years for multidrug-resistant TB (MDR-TB…
Qiaoling Ruan, Jingyu Zhou, Shufeng Weng, Lingyun Shao, Wenhong Zhang
…ts. The World Health Organization recommends LTBI treatment regimens, including 6 or 9 months of once-daily isoniazid (INH, H), 4 months of once-daily rifampin (RIF, R), 3 months of once-weekly rifapentine (RPT, P) plus INH (3HP), 3 months of once-daily RIF plus INH, or 1 month o…
Rosu L, Madan JJ, Tomeny EM, Muniyandi M, Nidoi J, et al.
…he STREAM stage 2 trial assessed two bedaquiline-containing regimens for rifampicin-resistant tuberculosis: a 9-month all-oral regimen and a 6-month regimen containing an injectable drug for the first 2 months. We did a within-trial economic evaluation of these regimens. Methods …
Oki Nugraha Putra, Telly Purnamasari
…t tuberculosis (XDR-TB) and MDR-TB[3]. It demonstrates that regimens containing pretomanid and BPaL or BPaLM were associated with favorable outcomes (cured). BPaLM consists of bedaquiline (400 mg once daily for the initial two weeks, followed by 200 mg thrice weekly for 22 weeks)…
Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galić S, et al.
…ile many TB drugs are available, identification of the best regimens is challenging because of the large number of possible drug-dose combinations. We have found consistently that responses of cells or whole animals to drug-dose stimulations fit a parabolic response surface (PRS)…
Goodall RL, Nunn AJ, Meredith SK, Bayissa A, Bhatnagar AK, et al.
…round STREAM stage 2 showed that two bedaquiline-containing regimens (a 9-month all-oral regimen and a 6-month regimen with 8 weeks of aminoglycoside) had superior efficacy to a 9-month injectable-containing regimen for rifampicin-resistant tuberculosis up to 76 weeks after rando…
Kavitha Saravu, Madhukar Pai
…drugs (e.g. bedaquiline) as well as shorter, individualized regimens, based on DST results.[2] In a study published in this issue of Lung India, Singh et al. reported on the treatment outcomes of a modified DOTS-plus strategy among 98 consecutive culture-proven adult MDR-TB patie…
Lindsay McKenna, Jennifer Furin
… needed on the safety and efficacy of pretomanid-containing regimens, and such data can be found in the paper published in The Lancet Respiratory Medicine by Conor Tweed and colleagues.6Tweed CD Dawson R Burger DA et al.Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide duri…
Gu P, Lu P, Ding H, Liu Q, Ding X, et al.
…ound To compare the effectiveness, cost, and safety of four regimens recommended by the World Health Organization (WHO) for rifampicin resistance/multidrug-resistance tuberculosis (RR/MDR-TB) Treatment in Eastern China. Methods We performed a cohort study among patients with RR/M…
Kwonjune J. Seung, Cathy Hewison
…rug-resistant tuberculosis to more effective and safer drug regimens that avoid debilitating side-effects, such as permanent hearing loss.2Farmer PE Better and safer treatment for multidrug-resistant tuberculosis.Lancet. 2018; 392: 798-800Summary Full Text Full Text PDF PubMed Sc…
Ryckman TS, McQuaid CF, Cohen T, Menzies NA, Kendall EA
…of separate rifampicin-susceptible and rifampicin-resistant regimens. We estimated incremental cures; averted deaths, secondary cases, and costs; and prices below which a pan-tuberculosis regimen would be cost saving. We also assessed scenarios intended to describe which mechanis…
Danyuchen Sun, Zhili Li, Yingpeng Qiu, Wei Shu, Lijie Zhang, et al.
…valuate the cost-effectiveness of two novel drug containing regimens compared to traditional regimen in Chinese adult population. **METHODS:** We performed a cost-effectiveness analysis from the perspective of the patient. Clinical treatment information and outcomes were retrosp…
Sisay M, Edessa D, Ayele Y, Getachew M
…pattern of and reasons for change of antiretroviral therapy regimens among HIV/AIDS patients at Jugel Hospital, Eastern Ethiopia. Methods A retrospective cross-sectional study was conducted to review medical records of 220 patients who had been on treatment and experienced regime…
Tari Nur Fauziyantini, Umi Yuniarni, Lanny Mulqie
…since 2023, Indonesia has implemented several TB-RO therapy regimens, namely BPaLM (6 months), BPaL (6 months), 9 month regimen, and long-term regimen (18-24 months). The choice of regimen is based on the patient's condition, treatment history, and level of resistance to certain …
N.А. Lytvynenko, Y. I. Feschenko, Maryna Pogrebna, A.S. Lapheta, L.V. Shcherbakova, et al.
…iveness of various shortened standard or modified treatment regimens for patients with multidrugresistant tuberculosis. Materials and methods. A prospective observational study was carried out to study different shortened AMBT regimens for 346 patients with multidrug-resistant t…
Nsengiyumva NP, Campbell JR, Oxlade O, Vesga JF, Lienhardt C, et al.
…r, and cheaper tuberculosis (TB) preventive treatment (TPT) regimens will enhance uptake and effectiveness. WHO developed target product profiles describing minimum requirements and optimal targets for key attributes of novel TPT regimens. We performed a cost-effectiveness analys…
Ding Y, Zhu H, Fu L, Zhang W, Wang B, et al.
…after 8 weeks). In conclusion, oral short-course three-drug regimens, including TBI-166 with high efficacy, were identified. The TBI-166+BDQ+PZA regimen is recommended for further study in a TBI-166 phase IIb clinical trial.
Innocent Murhula Kashongwe, Leopoldine Mbulula, Fina Mawete, Nicole Anshambi, Nadine Maingowa, et al.
…w approach improved favorable outcomes. Both short and long regimens reached a high level of favorable outcome compared to the previous study. The short regimen, well supervised seems to be superior to the long regimen in term of Death rate and loss to follow up (LTFU).
Bavesh D Kana
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…