Showing 26–50 of 200 documents
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Kendra Brett, Camille Dulong, Melissa Severn
…eing pulmonary TB.,Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Active TB disease occ…
Kuscu F, Yildirim F, Erturk D, Cabalak M, Komur S, et al.
Background About 10% of individuals with latent tuberculosis infection (LTBI) develop tuberculosis (TB) disease during their lifetime. People living with HIV (PLWH) have a significantly higher risk of developing tuberculosis disease from latent tuberculosis infection (LTBI) compa…
Sana Sharrack, Caroline Zollinger-Read
…ent the case of a 75-year-old male with no risk factors for latent tuberculosis (TB), who was diagnosed with rheumatoid arthritis and appropriately escalated to adalimumab after failing two csDMARDs. His pre-biologic screen revealed a negative IGRA and normal chest X-Ray. He resp…
…on. Currently, there are no comprehensive clinical practice guidelines providing recommendations for the screening, diagnosis, treatment, and prevention of TB in RD patients. To address this issue, the Collaborative Group for TB Prevention and Control in Patients with RD in China…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
… bacillus, Mycobacterium tuberculosis. Despite effective TB treatment being available for over 65 years, TB today causes 1.3 million deaths yearly, mostly in low- and middle-income countries. Drug-resistant TB is the leading cause of death owing to antimicrobial resistant disease…
Clare Bristow, Uli Schwab
…an Immunodeficiency Virus (HIV) are at an increased risk of latent Tuberculosis (TB) reactivation. HIV TB concurrent infection increases mortality and reduces patient quality of life. Screening for latent TB allows treatment to commence, preventing reactivation. In accordance wit…
Basu S, Sharma N, Mase S, Sachdeva KS
…enge of effective management to minimise the progression of latent TB infection (LTBI) to TB, thereby interrupting the chain of transmission. Approximately 5%-10% LTBI cases eventually develop TB in their lifetime with the risk being higher in children, people living with HIV/AID…
Ren B, Bai X, Zhang H, Sun L, Fang L, et al.
…sis (TB), and about 90% of those infected have asymptomatic latent infections. It has been reported that 85-90% of newly diagnosed active TB cases evolve from patients with latent tuberculosis infection (LTBI). In approximately 5-10% of patients, LTBI progresses to active TB duri…
Lee A, Xie YL, Barry CE, Chen RY
Guidelines on the treatment of tuberculosis (TB) have essentially remained the same for the past 35 years, but are now starting to change. Ongoing clinical trials will hopefully transform the landscape for treatment of drug sensitive TB, drug resistant TB, and latent TB infection…
Kendra Brett, Camille Dulong, Melissa Severn
…ion of TB bacteria.Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Brett K, Dulong C, Severn M
…on of TB bacteria. Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual who has the M. tuberculosis infection in which the bacteria are alive but are not currently causing active TB disease. Persons with LTBI do …
Bar-Meir M, Pariente G, Romem A, Wiener-Well Y
Objective Official guidelines recommend tuberculosis (TB) screening programmes for all healthcare workers (HCWs), along with offering treatment when latent TB infection (LTBI) is diagnosed. However, adherence to treatment among HCWs is lower compared with non-HCWs. The aim of the…
Dobler CC, Bosnic-Anticevich S, Armour CL
…was to explore the views of tuberculosis (TB) physicians on treatment of latent TB infection (LTBI), focusing on decision making and communication in clinical practice. 20 Australian TB physicians participated in a semistructured interview in person or over the telephone. Intervi…
O'Connell J, Oguntuase J, McConkey S, de Barra E
…on It is estimated that 24.8% of the world's population has latent TB. The World Health Organization's (WHO) End TB Strategy states that the systematic identification and management of LTBI in groups of people at high risk of reactivation is an essential part of TB elimination in…
Marais BJ
…d TB, but the establishment of functional TB prevention and treatment programs for children remains challenging. Barriers to TB prevention include: 1) non-implementation of existing guidelines, 2) perceived inability to rule out active TB with fear of creating drug resistance and…
Sachin Atre
…o years after diagnosis of the index case.[3] TB preventive treatment (TPT) is recommended for all groups who may have the latent TB infection. These include children below and >5 years of age, adolescents, and adult household contacts. TPT remains a vital component of the active…
Bedingfield N, Barss L, Oxlade O, Menzies D, Fisher D
Setting Identification, assessment, and treatment of latent TB infection (LTBI), collectively known as the LTBI cascade of care, is critical for TB prevention. Objective The objective of this research, conducted within the ACT4 trial, was to assess and strengthen the LTBI cascade…
Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, et al.
…ays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children who screened TST-positive but IGRA-negative. Objectives We performed a cohort study to evaluate the risk of TB disease in this group. Methods …
Brett K, Dulong C, Severn M
…xtrapulmonary TB). Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual whom does not have TB disease and may not possess any symptoms but has the M. tuberculosis infection. Persons with LTBI cannot spread TB inf…
Karishma Saran, Tiziana Masini, Isaac Chikwanha, Gregory Paton, Rosalind Scourse, et al.
…e a subset of 23 key policies in diagnosis, models of care, treatment, prevention, and drug regulation to provide a snapshot of national TB policy adoption and implementation. We examine progress since an analogous 2015 survey of 23 of the same countries. Results At the time of t…
Zolelwa Sifumba
…d by mycobacteria that are resistant to standard first-line treatment, typically isoniazid and rifampicin (Seung et al., 2015). In 2023, MDR-TB caused an estimated 150,000 deaths globally, and over half of the global number of patients with MDR-TB were based in five countries: In…
David S.C. Hui, Chi Chiu Leung
…ion highlights the importance for developing more effective treatment modalities in order to reduce morbidity and mortality. In this contemporary concise review, articles related to these common respiratory infections and TB published recently in Respirology and selected articles…
Medrano BA, Lee M, Gemeinhardt G, Yamba L, Restrepo BI
…mycobacteria (although less lung cavitations) in OA. During treatment, OA had less drug-resistant TB, few adverse reactions and adhered with TB treatment. We recommend training healthcare workers to 'think TB' in OA, for prompt treatment initiation to diminish deaths. Furthermore…
Yamile Zabana Abdo, R de Francisco, Iago Rodríguez–Lago, María Chaparro, Fernando Gomollón, et al.
…n of a patient in the INFEII registry, (2) the incidence of latent TB; and (3) compliance with national and European recommendations. Methods A longitudinal prospective study of incident cases with IBD, initiated in October 2016 and with a planned follow-up of 5 years. In Septemb…
Mehtani NJ, Puryear S, Pham P, Dooley KE, Shah M
…e with human immunodeficiency virus (PWH). The diagnosis of latent TB infection (LTBI) and treatment with TB preventative therapy (TPT) can reduce morbidity and mortality in this population. Historically, isoniazid has been recommended for TPT in PWH due to the absence of drug-dr…