Showing 26–50 of 200 documents
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LaFreniere M, Dam D, Strudwick L, McDermott S
Background Drug-resistant tuberculosis (TB) is a public health issue of global importance that poses a threat to TB control efforts. Canada conducts nationwide surveillance to monitor emerging drug resistance trends and document progress towards reaching the goal of TB eliminatio…
Wencong He, Yun‐Hong Tan, Peiying Li, Jingjing Bao, Yimeng Song, et al.
ObjectiveTo analyze the dynamic trend of drug resistance of Mycobacterium tuberculosis in Leiyang city, Hunan province from 2013 to 2017, and to understand the local drug resistance spectrum of M. tuberculosis, so as to provide evidences for the formulation of chemotherapy regime…
Mogashoa T, Melamu P, Derendinger B, Ley SD, Streicher EM, et al.
The emergence and transmission of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis (M.tb) strains is a threat to global tuberculosis (TB) control. The early detection of drug resistance is critical for patient management. The aim of this s…
Li Z, Liu F, Chen H, Han Y, You Y, et al.
…alence and significant clinical outcomes of pre-extensively drug-resistant plus additional drug-resistant tuberculosis (pre-XDR-plus) in Henan Provincial Chest Hospital between 2017 and 2021. Methods We analysed and summarized the drug sensitivity test (DST) results of clinical M…
Itu Singh, Utpal Sengupta
… continued till the appearance of primary and secondary DDS resistance during the 1970s.[45] Most of these DDS-resistant cases originated from fully treated relapse cases. However, it was noted that low doses of dapsone and irregular treatment were the major causes of relapse.[5]…
Li Q, Gao H, Zhang Z, Tian Y, Liu T, et al.
The emergence of drug-resistant tuberculosis (TB) is involved in ineffective treatment of TB, especially multidrug resistant/extensively resistant TB (MDR/XDR-TB), leading to acquired resistance and transmission of drug-resistant strains. Second-line drugs (SLD), including both f…
Lan Y, Li Y, Chen L, Zhang J, Zhang H
… TB in 2017. The objectives of this study were to determine drug resistance profiles of Mycobacterium tuberculosis clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-…
…le and author information Metrics Abstract The emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of Mtb to identify novel gene…
Kübra Yıldırım, Cemilenur Ataş, Ece Şimşek, Ahmet Yılmaz Çoban
…evaluate the AYC-SENSITIVE® kit for rapid detection of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) isolates. With the AYC-SENSITIVE® kit, a total of 36 isolates for susceptibility testing were evaluated (5 of which are standard (…
Pan Y, Yu Y, Yi Y, Dou X, Lu J, et al.
Background Diabetes mellitus (DM) and drug-resistant tuberculosis (DR-TB) are serious global public health problems. This study aimed to explore the differences in drug resistance between DR-TB patients with and without DM. Risk factors for developing multidrug-resistant tubercul…
Bashir Ullah, Rukhsana Saboor, Muhammad Zahid Iqbal, Atiq Ahmad Bhatti, Abad Ur Rehman, et al.
Aim: To determine the frequency of pre-extensively drug resistant tuberculosis, extensively drug resistant tuberculosis in patients with multi-drug resistant tuberculosis. Study design: Retrospective/observational Place and duration of study: Department of Medicine, Bolan Medical…
Alarcon-Braga EA, Salazar-Valdivia FE, Estrada-Grossmann JM, Mendez-Guerra C, Pacheco-Barrios N, et al.
Background The growing threat from pre-extensively drug-resistant tuberculosis (pre-XDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) poses a major public health concern in Latin America and the Caribbean (LAC). Therefore, this study aimed to summarize the available ev…
Shirin Tarafder, Bayzid Bin Monir
…a and to determine any relationship of these genotypes with drug resistance the most essential method is molecular typing. It allows a rapid and precise species differentiation. Objective: This study was intended to observe the genotypes of XDR mycobacterium tuberculosis by deter…
Shah I, Poojari V, Meshram H
…high burden countries for tuberculosis (TB) including multi-drug resistant TB (MDR-TB) and extensively-drug resistant (XDR) TB. Drug-resistant (DR) TB has threatened the TB care and is a major health problem in many countries; treatment of DR TB has been difficult requiring use o…
Mehrian P, Farnia P, Jalalvand D, Chamani MR, Bakhtiyari M
Purpose Multi-drug-resistant tuberculosis (MDR-TB) is simultaneously resistant to isoniazid and rifampin. Of course, this germ may also be resistant to other anti-tuberculosis drugs. Patients with extensively drug-resistant tuberculosis (XDR-TB) are also resistant to all types of…
Sadhana Awasthi, Neha Verma, Ram Gopal Nautiyal, Hariom Kumar Solanki
Background: Drug Resistant Tuberculosis (DR-TB) has frequently been encountered in India, and its presence has been known virtually from the time anti-TB drugs were introduced for the treatment of Tuberculosis. Multi Drug Resistant Tuberculosis (MDR-TB) is a man-made phenomenon a…
Yenew B, Kebede A, Alemu A, Diriba G, Mehammed Z, et al.
Background The emergence of drug-resistant tuberculosis (DR-TB) has been a major obstacle to global tuberculosis control programs, especially in developing countries, including Ethiopia. This study investigated drug resistance patterns and associated mutations of Mycobacterium tu…
Cuiyu Liu, Suping Li, Pan Baoshan, Hui Xing, Liang Bohui, et al.
Objective To understand the prevalence of drug resistance in pulmonary tuberculosis (TB) patients in Jiamusi, Heilongjiang province, and provide reliable references for the prevention and control of TB. Methods Mycobacterium tuberculosis strains isolated from 575 TB cases collect…
Mijala Bajracharya, Sanjeev Singh, Sabin Shrestha, Usha Giri
Introduction: Multi drug resistance is a serious threat for high prevalence countries and may have some effect on low prevalence countries and it is defined as resistance to at least isoniazid and rifampicin. Drug resistance tuberculosis results from in sufficient chemotherapy an…
Ncha R, Variava E, Otwombe K, Kawonga M, Martinson NA
…SCC) and factors predictive of TTSCC in patients with multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in the North-West Province. Methods A retrospective cohort study, abstracting patient demographic and clinical data, laboratory re…
Christoph Lange, Anca Vasiliù, Anna M. Mandalakas
… increase in the number of individuals identified with multidrug-resistant or rifampicin-resistant tuberculosis has been observed.1WHOGlobal tuberculosis report 2022. World Health Organization, Geneva2022Google Scholar Although a large part of this increase is attributed to impro…
Derner, Catherine Marie
…t challenges to effective treatment due to the emergence of drug-resistant strains. The prevalence and mechanisms of drug resistance amplification in TB remain areas of ongoing research and debate. This study investigated the consequences of suboptimal treatment on the acquisitio…
Mizukoshi F, Kobayashi N, Kirikae F, Ohta K, Tsuyuguchi K, et al.
Clinical isolates of drug-resistant (isoniazid and/or rifampicin-resistant) Mycobacterium tuberculosis were obtained from 254 patients diagnosed with drug-resistant tuberculosis in Japan from April 2015 to March 2017 in National Hospital Organization hospitals. The 254 patients w…
Susanna S van Wyk, Marriott Nliwasa, James A. Seddon, Graeme Hoddinott, Lario Viljoen, et al.
ABSTRACT Background Transmission of drug-resistant tuberculosis (TB) is ongoing, and many households face catastrophic costs when a member is diagnosed and treated for drug-resistant TB. Finding individuals with drug-resistant TB and initiating treatment as early as possible is i…
Abebaw Y, Abebe M, Tola HH, Mehammed Z, Getahun M, et al.
…acteriologically confirmed childhood Tuberculosis (PTB) and drug-resistant TB in Ethiopia is limited due to difficulties related to its diagnosis in this population. Therefore, this study aimed to assess bacteriologically confirmed childhood PTB Case Notification Rates (CNRs) and…