Showing 1–25 of 170 documents
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Qiuyao Zhan, Liang Zhou, Jianbo Fu, Xun Jiang, Xuan Liu, et al.
Vaccines are a cornerstone of global public health, but their efficacy can vary significantly among individuals. Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is one of the most used vaccines, and its efficacy is influenced by numerous factors, including sex, ag…
Ghasemi F, Kardan-Yamchi J, Heidary M, Karami-Zarandi M, Akrami S, et al.
…global tuberculosis (TB) epidemic. Bacille Calmette-Guérin (BCG), the only currently approved TB vaccine, is successful in preventing disseminated disease in newborns. However, it has a variable efficacy against pulmonary TB in adults. This protective effect of the vaccine varies…
Arrieta-Villegas C, Allepuz A, Grasa M, Martín M, Cervera Z, et al.
… infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated wit…
Moorlag SJCFM, Taks E, Ten Doesschate T, van der Vaart TW, Janssen AB, et al.
…uding coronavirus disease 2019 (COVID-19). The tuberculosis BCG vaccine may provide heterologous protection against nontuberculous infections and has been proposed as a potential preventive strategy against COVID-19. Methods In this multicenter, placebo-controlled trial, we rando…
Penn-Nicholson A, Tameris M, Smit E, Day TA, Musvosvi M, et al.
Background A vaccine that prevents pulmonary tuberculosis in adults is needed to halt transmission in endemic regions. This trial aimed to assess the safety and immunogenicity of three administrations at varying doses of antigen and adjuvant of an investigational vaccine (ID93 + …
Khan A, Singh VK, Mishra A, Soudani E, Bakhru P, et al.
…ople each year and the widely used Bacille Calmette-Guérin (BCG) vaccine provides a partial protection against TB in children and adults. Because BCG vaccine evades lysosomal fusion in antigen presenting cells (APCs), leading to an inefficient production of peptides and antigen p…
Singh DK, Dwivedi VP, Singh SP, Kumari A, Sharma SK, et al.
…infected and ~2 million deaths annually. The only available vaccine for TB, Bacillus Calmette Guérin (BCG), is ineffective against adult pulmonary TB. Therefore, alternate strategies that enhance vaccine efficacy are urgently needed. Vaccine efficacy and long-term immune memory a…
Sarfas C, White AD, Sibley L, Morrison AL, Gullick J, et al.
…tuberculosis (TB) is endemic, the Bacillus Calmette-Guérin (BCG) vaccine is given as close to birth as possible to protect infants and children from severe forms of TB. However, BCG has variable efficacy and is not as effective against adult pulmonary TB. At present, most animal …
Ahmad S, Bhattacharya D, Kar S, Ranganathan A, Van Kaer L, et al.
…ly worldwide. Mycobacterium bovis bacillus Calmette-Guérin (BCG), the only TB vaccine in common use, is effective against disseminated and meningeal TB in young children but is not effective against adult pulmonary TB. T helper 1 (Th1) cells producing interferon gamma (IFN-γ) and…
Dhiraj K Singh, Peter Um, Garima Arora, Xavier Alvarez, Vinay Shivanna, et al.
…h due to infection globally. Bacillus Calmette Guérin (BCG), a live attenuated bacterial strain, is the only available TB vaccine, but it has poor efficacy in preventing pulmonary TB in adults. There are advantages associated with the BCG platform however, including a remark…
Chen YQ, Cao SH, Yang XY, Liu Y, Li CY
Background The current prophylactic tuberculosis vaccine Bacille Calmette-Guérin (BCG), was derived in the 1920s, but the humoral immune responses induced by BCG vaccination have not been fully elucidated to date. In this study, our aim was to reveal the profiles of antibody resp…
Tameris M, Mearns H, Penn-Nicholson A, Gregg Y, Bilek N, et al.
…nd Infants are a key target population for new tuberculosis vaccines. We assessed the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmission of tuberculosis is very high. Methods We…
Wilkie MEM
…means there is a desperate need for a safe and effective TB vaccine. BCG is the only licensed vaccine and extremely variable in efficacy. However, BCG potentially exerts a non-specific beneficial effect - protecting infants from other causes of death such as respiratory infection…
de Gijsel D, von Reyn CF
Objectives The efficacy of childhood BCG vaccination in the prevention of adult pulmonary tuberculosis is not universally accepted. Methods We reviewed the published literature and summarized studies of BCG vaccination reporting long-term protection against pulmonary TB. Results …
Bitencourt J, Peralta-Álvarez MP, Wilkie M, Jacobs A, Wright D, et al.
…major global health problem and the only currently-licensed vaccine, BCG, is inadequate. Many TB vaccine candidates are designed to be given as a boost to BCG; an understanding of the BCG-induced immune response is therefore critical, and the opportunity to relate this to circums…
Taylor JW, Curtis N, Denholm J
Background The Bacille Calmette-Guérin (BCG) vaccine is primarily used to prevent tuberculosis (TB) infection and disease in settings with high TB incidence. Objective The aim of this review article is to describe the current uses of BCG vaccination in Australia, including the in…
Ahmad S, Bhattacharya D, Gupta N, Rawat V, Tousif S, et al.
…demic regions are vaccinated with Bacillus Calmette Guerin (BCG), which is the only usable vaccine available. BCG is efficacious against meningeal and disseminated TB in children, but protective responses are relatively short-lived and fail to protect against adult pulmonary TB. …
Rakshit S, Adiga V, Ahmed A, Parthiban C, Chetan Kumar N, et al.
This proof-of-concept study tested if prior BCG revaccination can qualitatively and quantitively enhance antibody and T-cell responses induced by Oxford/AstraZeneca ChAdOx1nCoV-19 or COVISHIELD™, an efficacious and the most widely distributed vaccine in India. We compared COVISHI…
Fang D, Wang R, Fan X, Li M, Qian C, et al.
…n lives per year in the world, whereas the only licensed TB vaccine BCG exhibits unsatisfactory efficacy in adults. Taking BCG as a vehicle to express Mtb antigens is a promising way to enhance its efficacy against Mtb infection. In this study, the immune efficacy of recombinatio…
Zhang Y, Xu D, Nie Q, Wang J, Fang D, et al.
…s of fatal infectious diseases worldwide. The only licensed vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), has variable efficacy against TB in adults. Insufficiency of immune cell function diminishes the protective effects of the BCG vaccine. It is critical to clari…
Prabowo SA, Zelmer A, Stockdale L, Ojha U, Smith SG, et al.
…d vaccination, in particular with Bacillus Calmette-Guérin (BCG), remain the main strategies to control TB. With the emergence of drug resistance, it has been proposed that a combination of TB vaccination with pharmacological treatment may provide a greater therapeutic value. We …
Sweeney E, Dahly D, Seddiq N, Corcoran G, Horgan M, et al.
…e from a single infectious agent. Bacillus Calmette-Guerin (BCG) is the only licensed vaccine for TB, yet its efficacy remains debated with variations in vaccine sub-strains, policies, and practices observed across the world. Three BCG vaccination policies were implemented across…
Ramos L, Obregon-Henao A, Henao-Tamayo M, Bowen R, Izzo A, et al.
Many vaccines against childhood diseases are administered early after birth, but vaccine development studies frequently test efficacy in adult rather than in neonatal animal models. In countries with endemic tuberculosis (TB), Bacillus Calmette-Guerin (BCG) is administered as par…
Festjens N, Vandewalle K, Houthuys E, Plets E, Vanderschaeghe D, et al.
The Mycobacterium bovis Bacille Calmette Guérin (BCG) vaccine shows variable efficacy in protection against adult tuberculosis (TB). Earlier, we have described a BCG mutant vaccine with a transposon insertion in the gene coding for the secreted acid phosphatase SapM, which led to…
Yun Xu, Xiaochun Wang, Qiangsen Zhong
Bacillus Calmette-Guérin (BCG) is the only vaccine currently used in clinical practice to prevent tuberculosis (TB), however, it remains limited in preventing latent infection, TB reactivation, and providing comprehensive protection. In this study, the pcaA gene, an antigen …