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World Health Organization
Mario Tovar, Yamir Moreno, Joaquín Sanz
Abstract In the development of vaccines against tuberculosis (TB), a number of factors represent burdensome difficulties for the design and interpretation of randomized control trials (RCTs) of vaccine efficacy. Among them, the complexity of the transmission chain of TB allows th…
Ochran Chetty, Cohen Chetty
… provide an overview of the clinical status of candidate TB vaccines and discuss the challenges and future development trends of novel TB vaccine research, in combination with a general overview of the Tuberculosis (TB) disease and Mycobacterium tuberculosis itself. Methods: Bibl…
Steven C. Derrick
ABSTRACT Our goal is to develop a pediatric combination vaccine to protect the vulnerable infant population against human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) infections. The vaccine consists of an auxotroph Mycobacterium tuberculosis strain that coexpresse…
Daphne T. Lianou, Charalambia K. Michael, Efthymia Petinaki, Vasia S. Mavrogianni, George C. Fthenakis
…sheep and goat farms, respectively. The increased number of vaccines administered was associated with a higher average milk production in the respective farms. There was an association of vaccination against staphylococcal mastitis with a reduced recovery of staphylococci from th…
Zhuang Li, Yilu Zhao, Ling Yang, Linsheng Li, Zhaoyang Ye, et al.
Tuberculosis (TB) is a global infectious disease posing a serious threat to human health, caused by Mycobacterium tuberculosis (MTB) infection. Although vaccination is the most effective way to prevent and control TB, the existing Bacillus Calmette–Guérin (BCG) vaccine exhibits l…
Naoto Kuroda
…tizens is necessary. If infants in Japan do not receive BCG vaccines, tuberculosis might spread. We must prevent this from happening by publicizing inadequate evidence of causality between the BCG and prevention of the COVID-19. We also need to highlight the concern that a shorta…
Azar Najafi, Nahid Mahdian, Bahman Yousefi, Mohsen Karbalaei, Ali Kermanjani, et al.
…d in vivo examinations, such as recombinant BCG (rBCG), DNA vaccines, and subunit vaccines. Factors, such as applicability of vaccine candidates in all individuals, cost-effectiveness, long-term immunity and stimulation of a wide range of responses are important factors. Now, mos…
E Kırımi, Grace Gakii Muthuri, Cyrus Gitonga Ngari, Stephen Karanja
Numerous prevention intervention strategies have been developed to curtail the spread of pulmonary tuberculosis to susceptible populations. However, pulmonary tuberculosis continues to claim many lives worldwide. In this paper, a deterministic mathematical model incorporating an …
Helena Beckhäuser Ubaldo, Ketley Schnorrenberger, Líris Besen Wolniewicz
…dhood. Thus, analysis of vaccination coverage (VC) of these vaccines and its relationship with pertussis cases in children under one year may indicate the effectiveness of these strategies. To evaluate VC of dTpa in pregnant women and pentavalent vaccine, and its correlation with…
Constanza Estefanía Martínez-Olivares, Vasti Lozano-Ordaz, Dulce Mata‐Espinosa, Jorge Barrios‐Payán, Angel E. Ortiz-Cabrera, et al.
… aimed to experimentally validate these peptides as subunit vaccines by determining their cytotoxicity, immunogenicity, and protective efficacy against Mycobacterium tuberculosis (Mtb) in mice when administered as a booster to BCG vaccination. Mice were vaccinated with BCG and, t…
Samaila Aboubacar, Soumana Alido, Kamayé Moumouni, Mamoudou Abdou Djafar, Garba Moumouni, et al.
Introduction: Tuberculosis remains a public health problem worldwide. The BCG vaccination is one of response means. The objective of this work was to study impact of BCG vaccination on morbidity and mortality related to childhood tuberculosis in Niamey. Patients and methods: It w…
Helena Beckhäuser Ubaldo, Ketley Schnorrenberger, Líris Besen Wolniewicz
…dhood. Thus, analysis of vaccination coverage (VC) of these vaccines and its relationship with pertussis cases in children under one year may indicate the effectiveness of these strategies. To evaluate VC of dTpa in pregnant women and pentavalent vaccine, and its correlation with…
Dana Ştefana Popescu, Anca Deleanu, Gindrovel Dumitra
Vaccine coverage for vaccines provided through the National Immunization Program is an element that is evaluated annually, including in Romania. Unfortunately, with the exception of the tuberculosis vaccine which has an optimal vaccine coverage (over 95%) both in total and in ar…
Ian Links, Laurence J. Denholm, Marilyn Evers, L. Kingham, Robert J. Greenstein
BACKGROUND: Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease (or paratuberculosis), a chronic wasting disease of ruminants and other animals resulting from granulomatous enteritis. There are increasing concerns that MAP is zoonotic. The prevalence of Johne…
Samaila Aboubacar, Soumana Alido, Kamayé Moumouni, Mamoudou Abdou Djafar, Garba Moumouni, et al.
Introduction: Tuberculosis remains a public health problem worldwide. The BCG vaccination is one of the response means. The objective of this work was to study the impact of BCG vaccination on morbidity and mortality related to childhood tuberculosis in Niamey. Patients and metho…
Ian Links, Laurence J. Denholm, Marilyn Evers, L. Kingham, Robert J. Greenstein
Abstract Background Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne’s disease (or paratuberculosis), a chronic wasting disease of ruminants and other animals resulting from granulomatous enteritis. There are increasing concerns that MAP is zoonotic. The prevalence …
Laura Sibley, Andrew White, Karen E. Gooch, Lisa Stevens, Rachel Tanner, et al.
Abstract This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals w…
Ebenezer Tumban
…-converting enzyme 2 receptor on the cells. Thus, candidate vaccines targeting the spike protein are currently being developed to prevent against infections. Approximately 44 SARS-CoV-2 candidate vaccines are in clinical trials (phase I-III) and an additional 164 candidates are i…
Arif Khan, Asad Khan, Irfan Khan, Muhammad Aamir Shehzad, Waqar Ali, et al.
…transformation technique to form a transgenic plant. Edible vaccines grip countless promise as a profitable, easily managing, can be store easily, unlikely or unable to fail and sociocultural gladly sustainable, particularly for the poor emerging nations. An edible vaccine takes …
Vasiliy Reshetnikov, Galina Shepelkova, Anna D. Rybakova, А. П. Трашков, Vladimir Yeremeev, et al.
mRNA vaccines turned out to be highly effective in combating the COVID-19 pandemic and other viral infections. Despite extensive study of mRNA vaccines in the last five years, the issue of safety of their use is still relevant. The study aimed to assess immunogenicity of two anti…
Özgül Kısa
…here isan urgent need for the development of alternative TB vaccines. Recently, new TB vaccine development efforts havebeen advanced in different clinical studies. Most of these vaccines are live-attenuated or recombinant mycobacterium,live viral vector-based, and protein/adjuvan…
Александр Сидорчук, Александр Сидорчук
The article describes the historical stages of creating vaccines against two of the most dangerous diseases, which, after the discovery of the microbial theory, were devoted to the efforts of scientists ― rabies and tuberculosis. The lecture describes the main achievements of L. …
U. Yu. Sirodzhidinova, U. I. Rozikov, S. M. Saydaliev, J. M. Yusupdzhanova
Aim . To study morphological changes in the lymph nodes of experimental animals vaccinated with BCG vaccine in high and low mountains. Material and Methods . Guinea pigs from the vivarium of the Central Research Laboratory of the Avicenna Tajik State Medical University were used …
Engi Seif E. Shaker, Noha Nabil Doghim, Arwa M. Hassan, Samia S. Musafa, Mohamed M. Fawzy
BACKGROUND: Warts are common viral infection of the skin. Treating warts are still an ongoing challenge and no general agreement is reached, on the best treatment, despite different therapeutic approaches. Intralesional (IL) immunotherapy has recently been shown to be effective i…