Showing 1–25 of 53 documents
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Wenping Gong, Jianping Xie, Hao Li, Ashok Aspatwar
…/tuberculosis). However, it is reported that the protective efficacy of BCG is highly variable and ranges between 0% and 80%, and its protection lasts only for 10 to 15 years [2]. Therefore, developing a new effective TB vaccine is pressing and challenging for governments and sci…
Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, et al.
Abstract The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased i…
Ahmed M. Abbas, Asmaa Abou‐Bakr, Nermeen Bahaa, Sherry Michael, Marco Ghobrial, et al.
… relationship between COVID-19 and Bacille Calmette Guérin (BCG) vaccine is still under investigation, and we aim to clarify this matter. Bacille Calmette Guérin is a live attenuated tuberculosis vaccine. BCG vaccination of adult humans induces strained circulating monocytes havi…
Mark F. Cotton, Helena Rabie
… control through vaccination remains a global priority. The efficacy of BCG given to neonates to prevent tuberculosis meningitis and miliary tuberculosis is well known.1Trunz BB Fine P Dye C Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis wo…
Mark F. Cotton, Helena Rabie
…lth Organization, Geneva2015Google Scholar and an effective vaccine was a key component of this strategy. Although tuberculosis vaccine research began in earnest in the 1990s, a strategic blueprint for tuberculosis vaccine development beyond the BCG vaccine was released in 2012. …
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, et al.
…uch-needed resources to find, diagnose and treat 40 million adults and children who will be affected by TB by 2022, and to conduct research on new diagnostics, treatments and vaccines required to achieve global TB control (Tiberi et al., 2018Tiberi S. Petersen E. Maeurer M. Ntoum…
Hafsa Farooq, Hamna Khan, Nimra Akhtar
…ost TB cases (95%) are found in low-income nations. Neonate BCG immunization is recommended by the WHO in countries with a "high prevalence" of tuberculosis.Objective: To determine the frequency of BCG vaccination in children diagnosed with pulmonary Tuberculosis at a tertiary ca…
Padmini Salgame, Vaishnavi Kaipilyawar
…or the largely variable protective effect against TB of the vaccine Bacille Calmette-Guerin (BCG) is not understood.In this study, we investigated whether epigenetic mechanisms are involved in the response of immune cells to the BCG vaccine.We isolated peripheral blood mononuclea…
Özgül Kısa
…iency Syndrome (AIDS). Currently, Bacillus Calmette-Guérin (BCG) vaccine is used to prevent tuberculous meningitisand miliary disease, particularly in young children, but its protective efficacy is variable in adults. Therefore, there isan urgent need for the development of alter…
Ahyar Ahmad, Andriansjah Rukmana, Miski Aghnia Khairinisa, Dian Ayu Eka Pitaloka, Rosana Agus, et al.
…h challenge worldwide. Currently, Bacillus Calmette-Guerin (BCG) is the only vaccine available for TB prophylaxis. However, the efficacy of the BCG vaccine against adult pulmonary TB is considered inconsistent. This condition encourages researchers to look for more effective opti…
Usama Sajjad, Khalid Khan Niazi, Gillian Beamer, Metin N. Gürcan
…over 2 billion individuals worldwide. Although the approved vaccine against TB, <i>M. bovis</i> Bacille Calmette-Guerin (BCG), successfully prevents TB meningitis and systemic TB in children, efficacy against pulmonary TB in adults is highly variable, ranging from 0% to 80…
Thomas E. Tavolara, Muhammad Khan Niazi, Gillian Beamer, Metin N. Gürcan
…utcomes, vaccination with M. bovis Bacille Calmette-Guerin (BCG) vaccine is used globally in children to prevent systemic disease and tuberculous meningitis. However, in adults, epidemiological studies show variable protection ranging from 0% to 80%. As a part of a larger study t…
Trim Lajqi, Natascha Köstlin‐Gille, Christian Gille
… innate immune cells to exhibit rapid action with increased efficacy against subsequent infections. Here we will discuss the role of TRIM and its implications for infectious diseases in childhood. The Concept of Trained Innate Memory Although lacking an adaptive immune system, pl…
Wenping Gong, Ashok Aspatwar, Jianping Xie, Hao Li
…24, demands urgent innovation [1]. The limited and variable efficacy (0-80%) of the Bacille Calmette-Guérin (BCG) vaccine in adults, a challenge starkly highlighted during the COVID-19 pandemic, underscores the critical need for novel prophylactic and therapeutic strategies [2][3…
M B Mouton, R M Horowitz, V M Limbert, L Bachnak, L A Morici, et al.
…ldwide. Intradermally administered Bacille Calmette-Guerin (BCG) is the only licensed Tb vaccine; however, BCG has limited efficacy in adults and vaccination site reactions. Additional issues include exclusion of immunocompromised/pregnant individuals, waning protection with age,…
Abiola Oduwole, JP Mwankon, Joseph Okebe, EB Esu, Moriam Chibuzor, et al.
Background: The Bacille Calmette-Guérin (BCG) vaccine, given as a single dose, offers variable protection against Tuberculosis (TB). It is plausible that repeat doses could improve the effectiveness of the BCG vaccine in settings where the population remain at risk of the disease…
Y. Su, Yin Cao, R L Wang, E J Dong, Weihong Zhao, et al.
Currently, Bacille Calmette-Guerin(BCG) is still the only admitted vaccine to prevent tuberculosis around the world. The target population is infants and children, but its protective efficacy is limited. As more and more studies have shown that re-vaccination with BCG protects ag…
Mohamed E. El Zowalaty, Hossam M. Ashour
…emely drug-resistant Mtb. In addition, the only approved TB vaccine is the current vaccine Bacille Calmette-Guérin (BCG), which provides partial and variable protection. Currently, there are at least 16 candidate vaccines in various stages of clinical development in the global TB…
Jorge Barrios‐Payán, Cristian Alfredo Segura-Cerda, Dulce Mata‐Espinosa, Helle Bielefeldt‐Ohmann, Rogélio Hernández‐Pando, et al.
…cination with Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is effective in controlling severe forms of TB in childhood, with limited efficacy in preventing lung disease in adults, which is further reduced by infection with Beijing strains.We previously showed that a standar…
Penny M. Heaton, Jeffrey S. Barrett
…scribes some of the institute's work on candidate drugs and vaccines against tuberculosis, the leading infectious diseases killer in the world. The Bill & Melinda Gates Medical Research Institute (Gates MRI) is a nonprofit biotechnology organization focused on diseases that dispr…
Ratih Pujilestari, Andriansjah Rukmana, Anis Karuniawati, M Usman, S Ismail, et al.
… Mycobacterium tuberculosis (Mtb). Bacille Calmette-Guérin (BCG) is the only licensed vaccine against TB, and it is effective in children but not in adults. The Vaccine Research Team, Department of Microbiology FKUI has developed a DNA-based TB vaccine candidate pcDNA3.1-rpfB. Th…
Xiaofang Zhao, Caihong Guo, Lianwen Wang, Zhijun Liu
…merge in the absence of systematic interventions. While the BCG vaccine provides substantial protection against infantile TB, its efficacy against pulmonary TB in adults varies significantly. Currently, six candidate vaccines aimed at preventing or delaying the progression from L…
Solomon Jauro, Erica C. Larson, Janelle L. Gleim, Brendon M. Wahlberg, Mark A. Rodgers, et al.
…in people living with HIV (PLWH). Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in infants, but its efficacy in adolescents and adults is limited. Here, we investigated the immune responses elicited by BCG administered via intravenous (IV) or intrader…
S.H. Choi, Jiyun Park, Jung Joo Hong, Sung Jae Shin, Ju Mi Lee
The Bacillus Calmette-Guérin (BCG) vaccine, the only licensed vaccine against tuberculosis (TB), has played a crucial role in mitigating severe manifestations of the disease, particularly in children. However, its effectiveness against pulmonary TB in adults remains variable, lar…