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World Health Organization
… handbook describes recommended shorter and longer all-oral regimens for MDR/RR-TB, including bedaquiline-containing regimens and the bedaquiline, pretomanid and linezolid (BPaL) regimen for selected patients with additional fluoroquinolone resistance. It also provides guidance o…
World Health Organization
…-month all-oral regimen and longer individualized treatment regimens. It also includes guidance on treatment for Hr-TB, adjunctive interventions such as surgery and corticosteroids, and programmatic implementation of MDR-TB services. Additional sections address treatment outcome …
World Health Organization
…s available evidence to inform recommendations on treatment regimens, including standard six-month regimens and shorter alternatives for drug-susceptible tuberculosis, as well as regimens of varying duration for drug-resistant tuberculosis. It also addresses key aspects of care a…
World Health Organization
…th rifampicin-based regimen for DS-TB and two newer 4-month regimens for specific patient groups, including adults, adolescents and children with non-severe disease. It details eligibility criteria, regimen composition, dosing, monitoring requirements and implementation considera…
World Health Organization
…n sheets for tuberculosis medicines used in DR-TB treatment regimens, covering mechanisms of action, dosing, formulations, pharmacokinetics, drug interactions, adverse reactions, contraindications and monitoring requirements. Additional sections address the management of adverse …
World Health Organization
…stant TB, given the increasing use of pretomanid-containing regimens and the absence of WHO-endorsed phenotypic testing criteria for these medicines. It summarizes systematic reviews, individual-level data analyses, pharmacokinetic and pharmacodynamic assessments, and evaluations…
World Health Organization
…. The handbook outlines standardized and shorter treatment regimens for drug-susceptible TB, comprehensive approaches to the management of rifampicin-resistant and multidrug-resistant TB, and key considerations related to diagnostics, drug susceptibility testing, monitoring and …
World Health Organization
This web annex to the second edition of the WHO operational handbook on tuberculosis, Module 1: Prevention – tuberculosis preventive treatment, presents pharmacokinetic modelling and simulation studies used to inform dosing recommendations for levofloxacin preventive therapy (6Lf…