Showing 1–14 of 14 documents
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Furin, Jennifer, Gegia, Medea, Mitnick, Carole, Rich, Michael, Shin, Sonya, et al.
World Health Organization
… handbook describes recommended shorter and longer all-oral regimens for MDR/RR-TB, including bedaquiline-containing regimens and the bedaquiline, pretomanid and linezolid (BPaL) regimen for selected patients with additional fluoroquinolone resistance. It also provides guidance o…
World Health Organization
…-month all-oral regimen and longer individualized treatment regimens. It also includes guidance on treatment for Hr-TB, adjunctive interventions such as surgery and corticosteroids, and programmatic implementation of MDR-TB services. Additional sections address treatment outcome …
World Health Organization
…dresses the use of preferred and alternative antiretroviral regimens across different populations, including adults, adolescents, pregnant women and children, with emphasis on treatment efficacy, safety, adherence and feasibility in low- and middle-income countries. The guidelin…
World Health Organization
…erapy (ART), second-line treatment strategies, dual-therapy regimens (oral and injectable), prevention of vertical HIV transmission, breastfeeding support and tuberculosis preventive treatment in people living with HIV. Dolutegravir-based regimens remain highly effective for seco…
World Health Organization
…s available evidence to inform recommendations on treatment regimens, including standard six-month regimens and shorter alternatives for drug-susceptible tuberculosis, as well as regimens of varying duration for drug-resistant tuberculosis. It also addresses key aspects of care a…
World Health Organization
…th rifampicin-based regimen for DS-TB and two newer 4-month regimens for specific patient groups, including adults, adolescents and children with non-severe disease. It details eligibility criteria, regimen composition, dosing, monitoring requirements and implementation considera…
World Health Organization
…n sheets for tuberculosis medicines used in DR-TB treatment regimens, covering mechanisms of action, dosing, formulations, pharmacokinetics, drug interactions, adverse reactions, contraindications and monitoring requirements. Additional sections address the management of adverse …
Suleiman, B.A., Houssein, A.I., Mehta, F., Hinderaker, S.G.
A cross-sectional study assessed the knowledge and practices of registered practitioners in management of tuberculosis [TB] in north-western Somalia. Of 100 registered doctors, 53 were interviewed. Of these, 32 [64%] had treated TB patients during the previous year, but only 1 ha…
World Health Organization
…stant TB, given the increasing use of pretomanid-containing regimens and the absence of WHO-endorsed phenotypic testing criteria for these medicines. It summarizes systematic reviews, individual-level data analyses, pharmacokinetic and pharmacodynamic assessments, and evaluations…
World Health Organization
This web annex to the second edition of the WHO operational handbook on tuberculosis, Module 1: Prevention – tuberculosis preventive treatment, presents pharmacokinetic modelling and simulation studies used to inform dosing recommendations for levofloxacin preventive therapy (6Lf…
World Health Organization
…pdates to neonatal and paediatric dosing, including revised regimens for commonly used medicines such as dolutegravir and abacavir/lamivudine, and provides detailed dosing tables for a range of formulations. Additional sections address considerations for preterm infants, differen…
World Health Organization
…. The handbook outlines standardized and shorter treatment regimens for drug-susceptible TB, comprehensive approaches to the management of rifampicin-resistant and multidrug-resistant TB, and key considerations related to diagnostics, drug susceptibility testing, monitoring and …
World Health Organization
…of treatment outcomes associated with pretomanid-containing regimens. The publication summarizes data generated from laboratory studies, clinical trials and individual-level analyses contributed by multiple international institutions and WHO reference laboratories. It discusses …