Showing 126–150 of 200 documents
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National Institute of Allergy and Infectious Diseases (NIAID)
…l suppression when dosed with rifapentine (RPT) 1200 mg for HIV-associated TB. This is an open-label, single arm, phase II, multicenter PK study to investigate the effect of daily RPT 1200 mg on DTG exposure in participants with HIV-associated TB. Adults with HIV with newly diag…
BONNET Maryline, MD
…he main objective is to compare the Pk parameters of EFV in HIV-TB co-infected patients, with and without TB treatment, using R at 10 and 20mg/Kg/day and EFV at 600 and 800mg/day. Justification: In vitro and animal studies have shown that increasing the dose of rifampicin (R) im…
Charles F. von Reyn, MD, Nyasule Majura-Neke, MD
… (PCS) to the standard treatments for tuberculosis (TB) and HIV will improve health outcomes. The investigators will enroll 180 HIV-positive women with newly diagnosed active TB and without prior anti-retroviral therapy (ART). At baseline, the investigators will conduct dietary i…
BLANC François-Xavier, MD, PhD, LAUREILLARD Didier, MD
…d tuberculosis (TB) regimen versus standard TB treatment in HIV-infected adults and adolescents hospitalized for TB with CD4 ≤ 100 cells/μL over 48 weeks: * Intensified TB treatment regimen: increased doses of rifampicin and isoniazid together with standard-dose of pyrazinamide …
Scott K Heysell
…mine the prospective influence of substance use patterns on HIV/tuberculosis adherence, pharmacokinetics and disease progression while developing novel methods for early detection and correction of these mechanisms of treatment failure in Irkutsk. At the University of Virginia, t…
Margaret Nansumba, MD
…sis of Tuberculosis in children in a setting of high TB and HIV prevalence can be improved and to assess the treatment outcomes and tolerance of the new WHO recommended TB drug dosages. Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. The situation…
Jason Farley, PhD, MPH, ANP-BC, Denise Evans, PhD, Norbert Ndjeka, MBChB
…-based outpatient sites among RR-TB patients, regardless of HIV co-infection, as determined by a successful treatment outcome \[H1\]. 2. The proportion of SAEs identified will not significantly differ by blinded, independent review \[H2\]. 3. Patient associated catastrophic costs…
Jason E Farley, PhD, MPH, NP
…programmatic management alone, in patients with and without HIV co-infection. To do this, the researchers will review the medical information collected at the hospital as part of the patient's treatment after obtaining the patient's permission. Mycobacterium tuberculosis (TB) re…
Christopher Hoffmann, MD, MPH
…multaneous TPT (TUTT-PT) to increase TPT initiation among PLHIV initiating (or re-initiating) ART and to characterize clinic level implementation determinants among health care workers. 1 Background HIV and TB in South Africa. South Africa is home to over 7.5 million people livi…
Andreas Diacon, MD, Henrik Aggerbeck, M.Sc.
…unteers suspected of having TB disease. With focus on age, HIV status and CD4 count the following analyses are done (in an overall perspective): * To compare the C-Tb test to a blood test, the QuantiFERON test. * To compare the C-Tb test to the PPD test that is currently being …
Joseph A Kovacs, M.D.
Background: Human immunodeficiency virus (HIV) is treated with antiretroviral drugs. Many people with HIV also have the lung infection tuberculosis (TB). Most TB treatments are complicated. A simpler treatment of two TB drugs can be taken once a week. Researchers want to study h…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
…ng from 4% to 21% \[8\], with younger age, malnutrition and HIV infection increasing the risk of death. The current standard of care (SOC) for young children with pneumonia considers a diagnosis of TB only if the child has a history of prolonged symptoms or fails to respond to a…
Awewura Kwara, MD, MPH&TM
…rug levels in the blood of children with TB with or without HIV infection. The treatment guidelines for childhood TB are largely inferred from studies in adults, as few controlled trials have been done in children to establish optimum regimens. The standard anti-TB treatment con…
Andrea S Winkler, M, PhdD
…p and test the effect of digital health messages related to HIV, Tuberculosis (TB) and Taenia solium cysticercosis/taeniosis (TSCT) (the intervention diseases) in Migoli and Izazi (the intervention villages), in Iringa, Tanzania (TZ). The intervention is planned as follows: A di…
Michael Herce, MD, MPH
…ll be used to characterize the full continuum of integrated HIV/TB care under Treatment as Prevention (TasP), and will enrich this approach by: 1) using individual-level cohort data for HIV-infected inmates to assess ART uptake under TasP/Universal Test and Treat (UTT), as well a…
Jessica F Magidson, PhD, Bronwyn J Myers, PhD
Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up (LTFU) in HIV/TB care. Patients with depression and s…
Stefan Niemann, PhD
…ogy. A particular gap in current knowledge is the effect of HIV and tuberculosis (TB) on the outcomes of COVID-19 disease as these two conditions impair the host immune response to other infectious disease. Understanding how these three pandemics interact is crucial. We have deve…
National Institute of Allergy and Infectious Diseases (NIAID)
…therapy. Half the participants will have active TB and also HIV infection, and the other half will have TB alone. Half the volunteers will be given vitamins, and the other half will be given placebo (sugar pill with no vitamins) from the start of their TB therapy, through the 8 m…
Thibaut Gelé, Daniel Atwine, Elisabeth Baudin, Winnie Muyindike, Kenneth Mworozi, et al.
…atment duration. Although previous data among patients with HIV-TB coinfection has shown that doubling rifampicin dosing had a small effect on EFV concentrations, its effect on the pharmacokinetics (PK) of antituberculosis drugs remains lacking in this population. **OBJECTIVES:*…
Eric R Houpt, MD
…iseases (NIH/NIAID) for US-Russia collaborative research in HIV/tuberculosis (TB). Given the exploratory focus of the protocol and the short time frame of funding (2 years) we will study TB in Irkutsk, in Eastern Siberia. Irkutsk is one of the hardest-hit areas in all of the Russ…
Tom Wingfield, PhD FRCP DTMH DipHIV, Vibol Lem, PhD
Tuberculosis (TB) remains the leading cause of death from a single infectious agent globally, with millions of people still undiagnosed or diagnosed late. Conventional case-finding strategies rely heavily on symptom screening using the WHO Four-Symptom Screen ((W4SS; comprising a…
Joseph A Kovacs, M.D.
People with human immunodeficiency virus (HIV) often take several medicines to control HIV. Dolutegravir and darunavir boosted with cobicistat are HIV medicines that people may take. They may also need to take medicines for an infection called latent tuberculosis (TB). Researcher…
Ifedayo Adetifa, FWACP, MSc
…ng the duration of potential transmission, and co prevalent HIV/AIDS are the major factors responsible for increasing TB incidence. The DOTs strategy, which relies on a process of passive TB case finding, has helped to control TB in many parts of the world. Currently, the World H…
Keertan Dheda, MBChB, PhD
…nd lateral flow urinary lipoarabinomannan (LAM) testing (in HIV +ve subjects only). The primary outcome is a comparison between the number of culture +ve subjects on TB treatment in each group at the end of two months. A secondary aim is an evaluation of the accuracy and feasibil…
David W. Haas, MD
…s (TB), an infectious disease that affects many people with HIV. RIF was shown to lower concentrations and decrease the effectiveness of some anti-HIV drugs, including the HIV protease inhibitor (PI) atazanavir (ATV) boosted with ritonavir (RTV). The purpose of this study is to d…