Showing 26–47 of 47 documents
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Joseph A Kovacs, M.D.
…HIV also have the lung infection tuberculosis (TB). Most TB treatments are complicated. A simpler treatment of two TB drugs can be taken once a week. Researchers want to study how the HIV and TB drugs affect each other so people who take both can be treated safely. Objective: T…
María Elvira Balcells, MD; MSc
…exposure within the household, during the first weeks of TB treatment initiation of the index case, can reduce new TB infections in close contacts. For this purpose, a pilot, controlled, pre-post study will be set up, to evaluate the feasibility of implementing a bundle of respir…
Jyoti S. Mathad, MD, MSc
…ted and HIV-1-uninfected pregnant and postpartum women with latent tuberculosis (TB). TB is a major cause of illness and death in women of reproductive age. Pregnant and postpartum women with latent TB are at higher risk of developing active TB. This study evaluated the pharmaco…
ASST Fatebenefratelli Sacco
…(hepatotoxicity) in adults treated for tuberculosis (TB) or latent tuberculosis infection (LTBI) and to understand which factors increase this risk. The study also aims to describe how hepatotoxicity is managed in real-world clinical practice and whether treatments such as cortic…
Stefania Cheli
…d prevent the occurrence of DILI and develop more effective treatments. Tuberculosis (TB) is the world's second leading cause of death from a single infectious agent in 2022, after COVID-19. In 2022, TB disease was estimated to affect 10.6 million people, of whom 1.3 million die…
Steven M Holland, M.D.
…in actively recruiting individuals with TB for research and treatment studies. Objectives: \- To collect blood and other samples to study the natural history of tuberculosis. Eligibility: \- Individuals 2 years of age and older who have either active or latent tuberculosis. …
Andrea A Howard, MD
…, transferred out); TB (tuberculosis) screening results; TB treatment (yes/no); TB treatment outcomes (if applicable); and retention in HIV care. A measurement cohort of 500 HIV-infected patients initiating IPT on or after July 1, 2013 will be recruited from the 10 clinics (n=25…
Gavin Churchyard, MBBCh, PhD
…n most high burden tuberculosis (TB) countries. In its 2015 guidelines, WHO includes 3HP as an latent tuberculosis infection (LTBI) treatment option for high-income and upper middle-income countries with TB incidence rates \<100/100,000. One trial comparing 3HP to 6H in a high bu…
Trevor Hansel, FRCPath, PhD, Peter JM Openshaw, FRCP, PhD, FRSB, FMedSci, Robin Shattock, PhD
…will be managed as per GCP and local Information Governance guidelines. NUMBER OF SUBJECTS AND DOSING PART 1: Nasal ascending dose challenge with microbial constituents using MPLA, polyIC, polyICLC and resiquimod. This is divided into part A and part B. PART 1A (n=32): Increme…
Chris J Griffiths, DPhil, MB BS
…ance level. Secondary outcomes are rates of prophylaxis for latent TB infection (LTBI), BCG immunisation, smear negative (early) TB and costs. Analyses will be by intention to treat. To date, studies of screening for tuberculosis have used relatively weak designs. A randomised t…
Michele L Pearson, MD, Sara J Whitehead, MD
…Healthcare facility Study Duration: 3 years; prevalence of latent Tuberculosis infection (LTBI) in healthcare workers (HCWs) will be at measured at baseline, and LTBI incidence will be measured among susceptible HCWs at 12 and 24 months. Secondary outcomes will be measures at 0 …
Timothy Sterling, MD, Robert Belknap, MD, Amber Robinson, PhD, Rosanna M Boyd, PhD, Dick Menzies, MD
…rm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care, control arm) of latent M. tuberculosis infection (LTBI). This trial is conducted among persons who are at increased risk of progression to tuberculosis (TB) and require treatment of LTBI. Th…
Jann-Yuan Wang, Ph.D.
…duction in TB incidence, or even elimination should rely on treatment for LTBI. However, which is the cost-effective screening method or what is the cost-effective regimen in Taiwan is still unclear. Therefore, the investigators designed this prospective study to follow up adult…
Gordin F, Brown LS
…of tuberculosis in patients who are coinfected with HIV and latent Mycobacterium tuberculosis (MTb). Current guidelines recommend 6 to 12 months of treatment with INH for purified protein derivative (PPD)-positive individuals. Problems with this treatment include compliance, adv…
Gavin Churchyard, MBBCh MMed FRCP FCP(SA) PhD, Amita Gupta, MD, MHS, Anneke Hesseling, MD, PhD, Susan Swindells, MBBS
…-risk HHCs are those with HIV or non-HIV immunosuppression, latent TB infection, and young children below the age of 5 years. This study will compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable ac…
Worku Nigussa, MD
… clinical decision-making. Since its endorsement by the WHO guidelines in 2010, Xpert MTB/RIF (Cepheid, CA, USA), a molecular test that can detect mycobacterial DNA and genetic polymorphisms associated with rifampicin resistance, has entered into diagnostic workup in both high- a…
Huashan Hospital
…-endemic areas. The pregnancy rate of assisted reproductive treatment (ART) in the infertile women with FGTB is still unsatisfied even after receiving standard anti-tuberculosis treatment. Moreover, recent years have witnessed an alarming increase in reports of FGTB-related mater…
David SC Hui, MD
…st in rheumatologic disease patients prior to initiation of treatment with biologic and/or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD). This is a prospective observational study involving the recruitment of patients with rheumatologic diseases who are pla…
Jason R Andrews, MD
This trial is designed to determine whether modifying the dose of isoniazid for individuals according to their n-acetyltransferase 2 (NAT2) genotype could increase the probability of achieving equivalence of area-under-the-curve.
Mark Hatherill
…hat MTBVAC will provide improved protection, as individuals latently infected with live M.tuberculosis have an 80% lower chance of developing TB, and as MTBVAC contains most of the genes deleted from BCG and presents a wider collection of antigens to the host immune system. Precl…
Rina La Distia Nora, MD, PhD
…until now corticosteroids and cycloplegics are the mainstay treatment for uveitis. However, appropriate administration of anti-infective drugs is necessary in cases of infection. Inflammation in TB-associated uveitis is thought to be the result of the immune response that occurs …
West China Hospital
…ll a lack of accurate and effective means for screening for latent tuberculosis infection. The tuberculosis interferon-γ release test has recently received more and more attention as a means of screening for potential tuberculosis infection. However, how to apply tuberculosis int…