Epetraborole pharmacokinetics/pharmacodynamics in the hollow fiber system model of.
Sanjay Singh, Megan Devine, Tawanda Gumbo, Shashikant Srivastava
Antimicrobial agents and chemotherapy · 2025-11
Abstract
In the hollow fiber system model of tuberculosis (TB), the ratio of area under the concentration-time curve to MIC (AUC/MIC) of 327.1 was identified as the epetraborole optimal exposure target forkill. Monte Carlo simulation experiments showed that even the intravenous dose of 1,500 mg/twice daily would fail in the majority of patients, and the dose needed for good efficacy for TB may likely not be safe for patients.
MeSH terms
- Mycobacterium tuberculosis
- Antitubercular Agents
- Microbial Sensitivity Tests
- Monte Carlo Method
- Humans
- Tuberculosis
- Area Under Curve