Contribution of front-line, standard-of-care drugs to bactericidal responses, resistance emergence, and cure in murine models of easy- or hard-to-treat tuberculosis disease.
Nathan Peroutka-Bigus, Elizabeth J Brooks, Michelle E Ramey, Hope D'Erasmo, Jackie P Ernest, Allison A Bauman, Lisa K Woolhiser, Radojka M Savic, et al. (12 authors)
Antimicrobial agents and chemotherapy · 2025-05
Abstract
By assessing the standard-of-care regimen for tuberculosis (TB) in BALB/c and C3HeB/FeJ mice, we demonstrate that rifampin, with or without pyrazinamide, is essential for an effective bactericidal response and suppression of resistance. Potency measurements in anlipid-rich model and a rabbit caseum assay recapitulate the significance of rifampin as a sterilizing agent. These outcomes align with clinical performance, thus emphasizing the value ofpredictive tools and murine TB models with human-like pathology.
MeSH terms
- Animals
- Pyrazinamide
- Rifampin
- Antitubercular Agents
- Mice
- Mycobacterium tuberculosis
- Mice, Inbred BALB C
- Rabbits
- Disease Models, Animal
- Microbial Sensitivity Tests
- Mice, Inbred C3H
- Tuberculosis
- Female
- Drug Resistance, Bacterial